DPF2 and NFKB2

Data Source:
BioGRID (pull down)

		DPF2	NFKB2
Description		double PHD fingers 2	nuclear factor kappa B subunit 2
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Centrosome Cytosol Intracellular Membrane-bounded Organelle NBAF Complex	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Bcl3/NF-kappaB2 Complex
	Molecular Function	Transcription Coregulator Activity Transcription Corepressor Activity Protein Binding Histone Binding Metal Ion Binding H3K9me3 Modified Histone Binding Lysine-acetylated Histone Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Apoptotic Process Nervous System Development Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Apoptotic Signaling Pathway Negative Regulation Of Myeloid Progenitor Cell Differentiation	Follicular Dendritic Cell Differentiation Germinal Center Formation Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Aging Extracellular Matrix Organization Positive Regulation Of Type I Interferon Production Response To Lipopolysaccharide Response To Cytokine NIK/NF-kappaB Signaling Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process Spleen Development Positive Regulation Of NF-kappaB Transcription Factor Activity
Pathways			RIP-mediated NFkB activation via ZBP1 DEx/H-box helicases activate type I IFN and inflammatory cytokines production PKMTs methylate histone lysines TAK1 activates NFkB by phosphorylation and activation of IKKs complex Interleukin-1 processing SUMOylation of immune response proteins IkBA variant leads to EDA-ID Dectin-1 mediated noncanonical NF-kB signaling NIK-->noncanonical NF-kB signaling The NLRP3 inflammasome TRAF6 mediated NF-kB activation Purinergic signaling in leishmaniasis infection
Drugs			Donepezil Glucosamine HE3286 P54 NOX-700 SGN-30 Custirsen NF-kappaB Decoy Andrographolide Glycyrrhizic acid Fish oil SC-236
Diseases
GWAS		Acne (severe) ( 24927181) Mean spheric corpuscular volume ( 32888494) Urate levels ( 31578528)	Metabolite levels ( 23823483) Refractive error ( 32231278) Ulcerative colitis ( 26192919) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		20 interacting genes: FHL2 GOLGA6L9 H3-4 H3C1 H4C1 HSF2BP LDOC1 LNX1 MEOX2 NFKB2 PICK1 REL RELB RINT1 RUBCN TTC23L TXNDC12 UPF2 ZNF212 ZNF655	36 interacting genes: BCL3 BTRC CHUK DDX3X DPF2 EPS8 GLG1 GTF2I HDAC4 HDAC5 IKBKB IKBKG MAP3K14 MAP3K8 MEN1 MTDH NFKB1 NFKBIA NFKBIB NFKBIE NFKBIZ NKRF NR3C1 NR5A1 PSMD11 REL RELA RELB RPL30 RPL6 RPS13 SIN3A SP1 TNIP2 TSC22D3 USP2
Entrez ID		5977	4791
HPRD ID		03394	01239
Ensembl ID		ENSG00000133884	ENSG00000077150
Uniprot IDs		A0A024R582 J3KMZ8 Q92785	Q00653
PDB IDs		3IUF 5B79 5VDC 6LTH 6LTJ	1A3Q 2D96 3DO7 4OT9 5ZMC
Enriched GO Terms of Interacting Partners?
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