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UPF1 and MIR221
Data Source:
BioGRID
(unspecified method)
UPF1
MIR221
Description
UPF1 RNA helicase and ATPase
microRNA 221
Image
No pdb structure
GO Annotations
Cellular Component
Chromosome, Telomeric Region
Chromatin
P-body
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Exon-exon Junction Complex
Supraspliceosomal Complex
Extracellular Space
Extracellular Vesicle
Molecular Function
Chromatin Binding
RNA Binding
RNA Helicase Activity
Helicase Activity
Protein Binding
ATP Binding
Zinc Ion Binding
Telomeric DNA Binding
MRNA Binding Involved In Posttranscriptional Gene Silencing
Biological Process
Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay
Nuclear-transcribed MRNA Catabolic Process, Endonucleolytic Cleavage-dependent Decay
Nuclear-transcribed MRNA Catabolic Process
DNA Replication
DNA Repair
MRNA Export From Nucleus
Regulation Of Translational Termination
Dosage Compensation By Inactivation Of X Chromosome
Viral Process
Telomere Maintenance Via Semi-conservative Replication
Regulation Of Telomere Maintenance
Cell Cycle Phase Transition
Positive Regulation Of MRNA Catabolic Process
3'-UTR-mediated MRNA Destabilization
Histone MRNA Catabolic Process
Cellular Response To Lipopolysaccharide
Cellular Response To Interleukin-1
Negative Regulation Of Cell Population Proliferation
Response To Glucose
Positive Regulation Of Epithelial Cell Migration
Positive Regulation Of Epithelial To Mesenchymal Transition
Negative Regulation Of Interleukin-21 Production
Negative Regulation Of Heterotypic Cell-cell Adhesion
Gene Silencing By MiRNA
MiRNA Mediated Inhibition Of Translation
Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Negative Regulation By Host Of Viral Genome Replication
Positive Regulation Of Erythrocyte Differentiation
Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT
Platelet-derived Growth Factor Receptor Signaling Pathway
Positive Regulation Of Axon Regeneration
Negative Regulation Of Inflammatory Response
Positive Regulation Of Protein Kinase B Signaling
Negative Regulation Of Cell Adhesion Molecule Production
Negative Regulation Of Necroptotic Process
Negative Regulation Of ERK1 And ERK2 Cascade
Positive Regulation Of ERK1 And ERK2 Cascade
Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis
Negative Regulation Of Cytokine Production Involved In Inflammatory Response
Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle
Positive Regulation Of Schwann Cell Migration
Negative Regulation Of Hematopoietic Stem Cell Proliferation
Negative Regulation Of TRAIL-activated Apoptotic Signaling Pathway
Negative Regulation Of Sprouting Angiogenesis
Positive Regulation Of Wound Healing, Spreading Of Epidermal Cells
Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration
Negative Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell
Positive Regulation Of Schwann Cell Proliferation Involved In Axon Regeneration
Negative Regulation Of Vascular Associated Smooth Muscle Cell Differentiation
Positive Regulation Of Vascular Associated Smooth Muscle Cell Dedifferentiation
Negative Regulation Of Double-strand Break Repair
Pathways
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS
Attention deficit hyperactivity disorder (
32595297
)
Interacting Genes
103 interacting genes:
ABHD16A
ACSS2
ATR
CSNK2B
DCP1A
DCP2
DXO
EIF3A
EIF3B
EIF4A3
EXOSC2
EXOSC4
GNPTG
HIRA
LSM8
MIR1-1
MIR1-2
MIR106A
MIR106B
MIR107
MIR10B
MIR122
MIR128-1
MIR128-2
MIR138-1
MIR138-2
MIR140
MIR141
MIR143
MIR145
MIR155
MIR15A
MIR15B
MIR16-1
MIR16-2
MIR17
MIR18A
MIR18B
MIR199A1
MIR199A2
MIR19A
MIR19B1
MIR19B2
MIR200A
MIR200B
MIR200C
MIR205
MIR206
MIR20A
MIR20B
MIR21
MIR214
MIR221
MIR222
MIR25
MIR29A
MIR29B1
MIR29B2
MIR29C
MIR31
MIR34A
MIR34B
MIR34C
MIR363
MIR429
MIR451A
MIR7-1
MIR7-2
MIR7-3
MIR9-1
MIR9-3
MIR92A1
MIR92A2
MIR93
MIR98
MIRLET7A1
MIRLET7A2
MIRLET7A3
MIRLET7B
MIRLET7C
MIRLET7D
MIRLET7E
MIRLET7F1
MIRLET7F2
MIRLET7G
MIRLET7I
NADSYN1
NDRG1
NDUFB10
PLEKHA5
PLEKHB2
POLR2A
PTEN
RHOXF2
RPRD2
SMG1
SMG5
STAU1
SUMO2
UPF2
UPF3A
UPF3B
XRN1
87 interacting genes:
ADARB1
AIMP2
APOBEC3B
AQR
C1QBP
CELF1
CPSF1
DARS1
DDX1
DDX21
DDX3X
DHX36
EIF2AK2
EPRS1
ERAL1
FAM98A
FIP1L1
FUS
G3BP2
HNRNPA0
HNRNPA1
HNRNPA2B1
HNRNPA3
HNRNPF
HNRNPH1
HNRNPH2
HNRNPH3
HNRNPK
HNRNPL
HNRNPM
HNRNPR
IARS1
IGF2BP1
IGF2BP2
IGF2BP3
KARS1
KNOP1
LARP7
LARS1
LIN28A
LIN28B
LRPPRC
MARS1
MATR3
MSI1
MSI2
MYEF2
NOL6
NONO
NUDT21
PDCD11
PLOD1
PRMT1
PTBP1
PTBP3
PUF60
PUM2
PURA
QARS1
RARS1
RBFOX2
RBM14
RBM4
RTCB
SART3
SF3A1
SF3A3
SF3B1
SF3B2
SF3B3
SF3B4
SFPQ
SPOUT1
STRBP
SUGP2
SYNCRIP
TAF15
TRA2A
TRA2B
TRIM25
U2SURP
UPF1
UTP20
YBX1
YBX2
YBX3
ZNF346
Entrez ID
5976
407006
HPRD ID
03254
Ensembl ID
ENSG00000005007
ENSG00000207870
Uniprot IDs
A0A024R7L5
A0A024R7L8
B3KY55
Q92900
PDB IDs
2GJK
2GK6
2GK7
2IYK
2WJV
2WJY
2XZO
2XZP
6EJ5
6Z3R
Enriched GO Terms of Interacting Partners
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