REL and ADRB2

Data Source:
BioGRID (two hybrid)

		REL	ADRB2
Description		REL proto-oncogene, NF-kB subunit	adrenoceptor beta 2
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytosol	Nucleus Lysosome Endosome Early Endosome Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Endosome Membrane Membrane Apical Plasma Membrane Clathrin-coated Vesicle Membrane Receptor Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding	Amyloid-beta Binding G Protein-coupled Receptor Activity Beta2-adrenergic Receptor Activity Protein Binding Adenylate Cyclase Binding Potassium Channel Regulator Activity Identical Protein Binding Protein Homodimerization Activity Protein-containing Complex Binding Norepinephrine Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Inflammatory Response I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Gene Expression Negative Regulation Of Interferon-beta Production Cellular Response To Stress Response To Cytokine NIK/NF-kappaB Signaling Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Neuron Death	Diet Induced Thermogenesis Norepinephrine-epinephrine-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure Regulation Of Sodium Ion Transport Desensitization Of G Protein-coupled Receptor Signaling Pathway By Arrestin Receptor-mediated Endocytosis Cell Surface Receptor Signaling Pathway Activation Of Transmembrane Receptor Protein Tyrosine Kinase Activity G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Endosome To Lysosome Transport Response To Cold Positive Regulation Of Protein Kinase A Signaling Protein Deubiquitination Positive Regulation Of Bone Mineralization Heat Generation Negative Regulation Of Multicellular Organism Growth Positive Regulation Of MAPK Cascade Bone Resorption Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Smooth Muscle Contraction Brown Fat Cell Differentiation Membrane Organization Positive Regulation Of Mini Excitatory Postsynaptic Potential Adrenergic Receptor Signaling Pathway Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of Autophagosome Maturation Positive Regulation Of Lipophagy Cellular Response To Amyloid-beta Response To Psychosocial Stress Positive Regulation Of CAMP-dependent Protein Kinase Activity Positive Regulation Of AMPA Receptor Activity
Pathways		Activation of NF-kappaB in B cells	Adrenoceptors G alpha (s) signalling events Ub-specific processing proteases Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis ADORA2B mediated anti-inflammatory cytokines production
Drugs			Spermine Amphetamine Betaxolol Bethanidine Isoetharine Cabergoline Metoprolol Olanzapine Atenolol Norepinephrine Timolol Phenylpropanolamine Dipivefrin Sotalol Carteolol Nortriptyline Propranolol Labetalol Bisoprolol Epinephrine Paroxetine Trimipramine Cryptenamine Orciprenaline Dobutamine Pseudoephedrine Alprenolol Ritodrine Terbutaline Bitolterol Phenoxybenzamine Salmeterol Pindolol Formoterol Salbutamol Ergoloid mesylate Isoprenaline Arbutamine Amiodarone Carvedilol Desipramine Propafenone Acebutolol Nadolol Levobunolol Metipranolol Aripiprazole Arformoterol Fenoterol Pirbuterol Bevantolol Penbutolol Ephedra sinica root Ephedrine Mephentermine Procaterol Clenbuterol Bambuterol Oxprenolol Putrescine Spermidine Celiprolol Nebivolol Indacaterol Bedoradrine NCX 950 Asenapine Droxidopa Bufuralol Protokylol (S)-carazolol Bopindolol Bupranolol Befunolol Olodaterol Vilanterol Arotinolol Doxofylline Racepinephrine Dihydroergocornine DL-Methylephedrine Etafedrine Tulobuterol Levosalbutamol Dihydroergocristine
Diseases		Hodgkin lymphoma	Asthma
GWAS		Celiac disease ( 20190752) Celiac disease and Rheumatoid arthritis ( 26546613) Crohn's disease ( 22412388 21102463) Erectile dysfunction ( 30583798) Hodgkin's lymphoma ( 21037568 24920014) Inflammatory bowel disease ( 23128233) Psoriasis ( 25903422 20953190 25574825 23143594) Psoriasis vulgaris ( 26626624) Psoriatic arthritis ( 26626624 22170493) Rheumatoid arthritis ( 30423114 23143596 24390342 20453842 19503088) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Ulcerative colitis ( 20228799)	Chronic obstructive pulmonary disease ( 30804561) Eosinophil percentage of white cells ( 32888494) FEV1 ( 30804560) Lung function (FEV1/FVC) ( 30804560) Lymphocyte percentage of white cells ( 27863252) Peak expiratory flow ( 30804560) Systolic blood pressure ( 29615537)
Interacting Genes		319 interacting genes: A1CF AAAS ACBD4 ACOT12 ACOT8 ACTN3 ADRB2 ADSL AGPAT4 AKT2 ALOX5 AQP1 AR ARFIP2 ARIH2 ARL16 ARMC7 ARNT2 ASAP3 ASMTL ATG9A ATP6V0D2 ATP6V1C2 ATPAF2 ATXN1 BANP BARHL2 BBS4 BCL2L15 BCL6 BID BMF C11orf68 C12orf75 C14orf119 C1orf109 C1orf50 C1orf56 C1orf74 C9orf72 CABP5 CACNA1S CALM1 CCNC CCNE1 CCNJL CDK18 CDKN1A CDKN2C CDKN2D CDR2L CENPX CEP19 CFAP206 CGGBP1 CHAF1A CHCHD2 CHIC2 CIB3 CINP CKS1B CLIC4 CLIP1 COL20A1 COL8A1 CPNE2 CPNE7 CPSF1 CSNK2A1 CTNNA3 CTNNBIP1 CXCL14 CYB5R2 DAAM2 DDX6 DEF6 DGCR6 DHPS DMRT3 DNTT DPF2 DYNC1LI1 EFHC1 EHHADH EIF3A EIF3D EIF4A3 EIF4E2 EIF4EBP1 EIF5A EIF5A2 ELF1 EMD EML2 EP300 EPHB6 EPM2AIP1 ESRRA ESRRG EXOSC1 EXOSC5 EXOSC8 FAAP20 FAM90A1 FHIT FHL2 FKBP1B FLAD1 FLNA FNDC11 FNDC3B FOXO4 FUT11 GADD45G GLYCTK GPKOW GRAP GRB2 GTF2B HAT1 HDAC7 HIP1 HLA-DOA HNRNPF HNRNPLL HSD17B14 HSPA4 HSPA8 HSPB7 IL36RN KCTD6 KCTD7 KIAA0100 KLHL32 KLHL40 KLHL42 KRTAP9-4 L3MBTL2 LASP1 LENG1 LGALS14 LMO1 LMO2 LNPEP LSM2 MAD2L2 MAGOHB MAP3K7CL MAP3K8 MAPK8 MAPRE3 MB21D2 MBD3 MEMO1 MID2 MIEN1 MIPOL1 MLIP MMP2 MORF4L1 MORF4L2 MRPL10 MSRB3 MTPN MTURN MVP MYO15B NABP1 NAGK NCK2 NDE1 NDUFAF3 NECAP1 NEDD9 NEIL2 NEUROG3 NFKB1 NFKB2 NFKBIA NFKBIB NFKBIE NGB NKRF NME7 NMRK1 NOL9 NOTCH1 NOXA1 NR2C2AP NUCB1 NUDT10 NUDT14 NXT2 OAZ3 OSGIN1 OSTF1 OTUB2 OTUD4 PADI3 PAK1IP1 PARVG PATE1 PCYT2 PELI2 PGAP6 PICK1 PIH1D2 PLCB4 PLEKHN1 PM20D2 POLE2 POLR1A POLR2L POP5 PPP4C PRDM10 PRKAA2 PRKAB2 PRKN PRPF31 PSMA1 PSMA4 PSMB8 PSORS1C2 PTGER3 PTK6 QARS1 R3HDM2 RAB29 RAB41 RABIF RAD23A RAD51D RASSF5 RBM39 RECK RELA REXO1L6P RIPPLY1 RNF213 RNF6 RSPH14 RTL8C RUNX1T1 S100A1 SAMD11 SAT1 SCNM1 SDCBP SEC14L4 SEC31A SEPTIN7 SHC3 SIN3A SIX1 SLC39A13 SLC41A3 SLC6A12 SMG9 SNRNP25 SP1 SPATC1L SPG21 SPRY1 SRF STAMBPL1 STK16 SULT2B1 SUOX SZT2 TBC1D21 TBC1D22B TBP TCL1A TCP11L1 TDO2 THOC1 TLE5 TLX3 TMEM165 TMEM268 TNIP2 TNS2 TRAPPC2L TRAPPC6A TRIM27 TRIM68 TRIM74 TSC22D3 TSEN15 TSPOAP1 TSSC4 TSSK3 TSTD2 TTC19 TTC21A TXNL4B UBASH3A UBASH3B UBE2D4 UBE2K UBE2Z UBXN7 VPS25 WNK3 YARS1 YJU2 ZBED8 ZBTB16 ZDHHC24 ZIC1 ZNF417 ZNF446 ZNF550 ZNF564 ZNF572 ZNF688 ZNF76 ZNF765	160 interacting genes: ABCA7 ADGRG1 ADRB3 AKAP12 AKAP5 ALDOA ARF4 ARHGAP5 ARHGDIA ARR3 ARRB1 ARRB2 ARRDC3 ARV1 ATP6V0B ATP6V0D1 BACE1 BAZ2A BSG CAV3 CCKBR CCND2 CD4 CD68 CD81 CD9 CEACAM1 CENPB CLASP2 CLPTM1L CNN1 CRYM CSK DCAF10 DCLRE1A DNAJC14 DRD4 EGLN3 EIF2B1 FBXO17 GBP5 GJC2 GMPR2 GNA11 GNA14 GNA15 GNAI1 GNAI2 GNAS GNAT2 GNB1 GNG2 GNL3L GOLGB1 GPR37 GPRASP1 GPRC5B GRB2 GRIA3 GRK1 GRK2 GRK3 GRK4 GRK5 GRK6 GTF2B HDAC6 HNRNPK HS2ST1 HTR4 IL1B IL6R INSR KCNE1 KCNJ5 KCNJ6 KCNJ9 KCTD13 KLC1 LRATD2 MAPK8IP2 MBOAT2 MBP MCAM MDM2 MFSD12 MFSD2A MGLL MITF MOG MSR1 NAT14 NCOR2 NEDD4 NIPAL2 NOS1 NPTX1 OBP2A OPRD1 PLA2G2D PRDX1 PRKCD PRNP PTGDS PTGER1 PTGES2 RAB14 RAB27A RAB3A RACK1 RAN RAP2C REL RGR RGS10 RGS11 RGS17 RGS2 RGS20 RGS5 RGS8 RGS9 RHOD RIOX1 RNF41 RTN1 SACS SENP3 SI SLC37A1 SLC39A4 SLC52A2 SLC9A3R1 SLC9A3R2 SNCA SNCG SPTBN2 SRC STAT3 STAT4 TCTA TMCC2 TMEM144 TMEM187 TMEM259 TPTE TSG101 TSHR TSPAN7 UCHL1 UST VAPA VDAC1 VDAC2 VEGFB WNK1 YIPF5 YWHAQ ZNF25 ZNF254
Entrez ID		5966	154
HPRD ID		01286	00187
Ensembl ID		ENSG00000162924	ENSG00000169252
Uniprot IDs		Q04864	P07550 X5DQM5
PDB IDs			1GQ4 2R4R 2R4S 2RH1 3D4S 3KJ6 3NY8 3NY9 3NYA 3P0G 3PDS 3SN6 4GBR 4LDE 4LDL 4LDO 4QKX 5D5A 5D5B 5D6L 5JQH 5X7D 6E67 6KR8 6MXT 6N48 6NI3 6OBA 6PRZ 6PS0 6PS1 6PS2 6PS3 6PS4 6PS5 6PS6 7BZ2
Enriched GO Terms of Interacting Partners?
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