BCKDHB and BCKDHA

Data Source:
HPRD (in vitro)

		BCKDHB	BCKDHA
Description		branched chain keto acid dehydrogenase E1 subunit beta	branched chain keto acid dehydrogenase E1 subunit alpha
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GO Annotations	Cellular Component	Nucleolus Mitochondrion Mitochondrial Matrix Mitochondrial Alpha-ketoglutarate Dehydrogenase Complex	Mitochondrion Mitochondrial Matrix Mitochondrial Alpha-ketoglutarate Dehydrogenase Complex
	Molecular Function	Alpha-ketoacid Dehydrogenase Activity 3-methyl-2-oxobutanoate Dehydrogenase (2-methylpropanoyl-transferring) Activity Protein Binding	Alpha-ketoacid Dehydrogenase Activity 3-methyl-2-oxobutanoate Dehydrogenase (2-methylpropanoyl-transferring) Activity Protein Binding Carboxy-lyase Activity Metal Ion Binding
	Biological Process	Response To Nutrient Branched-chain Amino Acid Catabolic Process	Branched-chain Amino Acid Catabolic Process
Pathways		Glyoxylate metabolism and glycine degradation Branched-chain amino acid catabolism	Glyoxylate metabolism and glycine degradation Branched-chain amino acid catabolism
Drugs
Diseases		Maple syrup urine disease (MSUD)	Maple syrup urine disease (MSUD)
GWAS		Adolescent idiopathic scoliosis ( 31417091) Diastolic blood pressure ( 30224653) Height ( 28552196 25282103 23563607 31562340) Joint mobility (Beighton score) ( 27182965) Protein level change in low calorie diet obesity intervention ( 29234017) Prudent dietary pattern ( 28644415) Sitting height ratio ( 25865494) Spine bone size ( 31053729) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for body mass index ( 28448500)	Height ( 25282103 31562340)
Interacting Genes		1 interacting genes: BCKDHA	1 interacting genes: BCKDHB
Entrez ID		594	593
HPRD ID		02011	02009
Ensembl ID		ENSG00000083123	ENSG00000248098
Uniprot IDs		A0A140VKB3 B4E2N3 B7ZB80 P21953	A0A024R0K3 P12694 Q59EI3
PDB IDs		1DTW 1OLS 1OLU 1OLX 1U5B 1V11 1V16 1V1M 1V1R 1WCI 1X7W 1X7X 1X7Y 1X7Z 1X80 2BEU 2BEV 2BEW 2BFB 2BFC 2BFD 2BFE 2BFF 2J9F	1DTW 1OLS 1OLU 1OLX 1U5B 1V11 1V16 1V1M 1V1R 1WCI 1X7W 1X7X 1X7Y 1X7Z 1X80 2BEU 2BEV 2BEW 2BFB 2BFC 2BFD 2BFE 2BFF 2J9F
Enriched GO Terms of Interacting Partners?
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