PLEKHA1 and MPDZ

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		PLEKHA1	MPDZ
Description		pleckstrin homology domain containing A1	multiple PDZ domain crumbs cell polarity complex component
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane Ruffle Membrane Extracellular Exosome	Cytoplasm Bicellular Tight Junction Postsynaptic Density Apical Plasma Membrane Apicolateral Plasma Membrane Dendrite
	Molecular Function	Protein Binding Lipid Binding PDZ Domain Binding Phosphatidylinositol-3,4-bisphosphate Binding	Protein Binding Protein C-terminus Binding
	Biological Process	Luteinization Phosphatidylinositol Biosynthetic Process Spermatogenesis Androgen Metabolic Process Estrogen Metabolic Process Post-embryonic Development Phosphatidylinositol 3-kinase Signaling Ruffle Organization Leydig Cell Differentiation Multicellular Organism Growth Establishment Of Protein Localization Platelet-derived Growth Factor Receptor Signaling Pathway Skeletal System Morphogenesis B Cell Receptor Signaling Pathway Negative Regulation Of Protein Kinase B Signaling Roof Of Mouth Development Face Morphogenesis Cellular Response To Hydrogen Peroxide	Viral Process
Pathways		Synthesis of PIPs at the plasma membrane
Drugs		Citric acid
Diseases
GWAS		Age-related macular degeneration ( 23577725 23536807) Age-related macular degeneration (extreme sampling) ( 23577725) Autoimmune thyroid disease ( 32581359) Birth weight ( 31043758 27680694) Central corneal thickness ( 32528159) Femoral neck bone mineral density ( 29499414) Height ( 31562340 20189936) Medication use (thyroid preparations) ( 31015401) Offspring birth weight ( 31043758) Refractive error ( 32231278) Type 1 diabetes in high risk HLA genotype individuals (time to event) ( 29310926) Type 2 diabetes ( 28566273 24509480 30054458 30297969 32499647 30718926 28869590)	Central corneal thickness ( 32528159 29760442) Corneal hysteresis ( 30894546) Corneal structure ( 23291589) Heel bone mineral density ( 30598549 28869591) Refractive astigmatism ( 30306274) Triglyceride levels ( 32203549)
Interacting Genes		8 interacting genes: CLDN14 CRKL FBXO7 MPDZ PLEKHA2 PTPN13 SH3BP4 SNTG1	16 interacting genes: ABCA1 CAMK2A CLDN1 CLDN5 CRHR1 CSPG4 DRD3 F11R HTR2C KIT MTNR1A PLEKHA1 PLEKHA2 RNF5 SYNGAP1 TSC22D2
Entrez ID		59338	8777
HPRD ID		09686	09155
Ensembl ID		ENSG00000107679	ENSG00000107186
Uniprot IDs		B3KQL5 Q5RGS4 Q9HB21	O75970
PDB IDs		1EAZ	2FCF 2FNE 2IWN 2IWO 2IWP 2IWQ 2O2T 2OPG 2QG1
Enriched GO Terms of Interacting Partners?
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