RBBP6 and CAPZA2

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		RBBP6	CAPZA2
Description		RB binding protein 6, ubiquitin ligase	capping actin protein of muscle Z-line subunit alpha 2
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome Nucleolus Centrosome Cytosol Nuclear Speck Protein-containing Complex	Extracellular Region Cytosol Brush Border F-actin Capping Protein Complex Actin Cytoskeleton Membrane Cortical Cytoskeleton Extracellular Exosome
	Molecular Function	RNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Protein Kinase Binding Ubiquitin Protein Ligase Activity	Protein Binding Actin Filament Binding
	Biological Process	Protein Polyubiquitination In Utero Embryonic Development DNA Replication Regulation Of DNA Replication MRNA Processing Ubiquitin-dependent Protein Catabolic Process Cellular Response To DNA Damage Stimulus Multicellular Organism Growth Embryonic Organ Development Somite Development	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Blood Coagulation Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Actin Cytoskeleton Organization Innate Immune Response Barbed-end Actin Filament Capping Protein-containing Complex Assembly
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	MHC class II antigen presentation HSP90 chaperone cycle for steroid hormone receptors (SHR) COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic Advanced glycosylation endproduct receptor signaling Factors involved in megakaryocyte development and platelet production Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Adult body size ( 32376654) Body mass index ( 28892062) Body size at age 10 ( 32376654) Brain structure ( 20171287) Chronotype ( 30696823) Obesity-related traits ( 23251661) Pulse pressure ( 27841878) Systolic blood pressure ( 27841878)	Mean platelet volume ( 32888494 27863252) Platelet count ( 32888494 27863252) Platelet distribution width ( 32888494 27863252) Plateletcrit ( 32888494 27863252) Pulse pressure ( 27841878) Triglyceride levels ( 32203549 32154731) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		40 interacting genes: ACOT13 ANAPC16 APOH ASGR1 CAPZA2 CASK CD81 CLK1 ETS1 EVA1C FAAP24 FBXO7 GLUL GRB2 HP KHDRBS3 LINC00305 LRCH4 MAD2L2 MDM2 MIR19A MIR19B1 NDUFB9 NEK6 PIAS1 PLG RB1 RBP4 RCC1L RPS14 SMN1 SPP1 TP53 TPT1 UBE2I UPF3B VAV2 YBX1 ZBTB38 ZFYVE9	3 interacting genes: CAPZA3 HSPB2 RBBP6
Entrez ID		5930	830
HPRD ID		02964	11871
Ensembl ID		ENSG00000122257	ENSG00000198898
Uniprot IDs		Q7Z6E9	A4D0V4 P47755
PDB IDs		2C7H 2YSA 2YUR 3ZTG 6E5X
Enriched GO Terms of Interacting Partners?
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