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RAP1B and CHGB
Data Source:
BioGRID
(two hybrid)
RAP1B
CHGB
Description
RAP1B, member of RAS oncogene family
chromogranin B
Image
No pdb structure
GO Annotations
Cellular Component
Lipid Droplet
Cytosol
Plasma Membrane
Cell-cell Junction
Membrane
Azurophil Granule Membrane
Membrane Raft
Extracellular Exosome
Extracellular Space
Endoplasmic Reticulum Lumen
Secretory Granule
Molecular Function
GTPase Activity
Protein Binding
GTP Binding
GDP Binding
Protein-containing Complex Binding
Hormone Activity
Protein Binding
Biological Process
Cell Population Proliferation
Response To Carbohydrate
Microvillus Assembly
Rap Protein Signal Transduction
Positive Regulation Of Integrin Activation
Cellular Response To Drug
Interleukin-12-mediated Signaling Pathway
Neutrophil Degranulation
Negative Regulation Of Calcium Ion-dependent Exocytosis
Establishment Of Endothelial Barrier
Positive Regulation Of ERK1 And ERK2 Cascade
Cellular Response To CAMP
Cellular Response To Gonadotropin-releasing Hormone
Regulation Of Cell Junction Assembly
Regulation Of Establishment Of Cell Polarity
Negative Regulation Of Synaptic Vesicle Exocytosis
Signal Transduction
Post-translational Protein Modification
Cellular Protein Metabolic Process
Pathways
Integrin signaling
GRB2:SOS provides linkage to MAPK signaling for Integrins
p130Cas linkage to MAPK signaling for integrins
Rap1 signalling
MAP2K and MAPK activation
Neutrophil degranulation
Signaling by moderate kinase activity BRAF mutants
Signaling by high-kinase activity BRAF mutants
Signaling by BRAF and RAF fusions
Paradoxical activation of RAF signaling by kinase inactive BRAF
MET activates RAP1 and RAC1
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Signaling downstream of RAS mutants
Signaling by RAF1 mutants
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Post-translational protein phosphorylation
Drugs
Diseases
GWAS
Femoral neck bone mineral density (
32239398
)
Femoral neck bone mineral density and trunk fat mass adjusted by trunk lean mass (
32239398
)
White blood cell count (
20139978
)
Metabolite levels (
23823483
)
Uterine fibroid number (single vs multiple) (
30196971
)
Interacting Genes
30 interacting genes:
A2M
ALAS1
APLP1
APP
CCT7
CHGB
CSAD
DDAH2
FAF1
HRAS
KMT2B
LRIF1
MTUS2
PDHB
PKM
PRKACA
RAB7B
RALGDS
RAPGEF1
RASSF5
RGL2
RGS2
RPTOR
SDF4
SMURF2
TLE1
TP53
UNC119
ZDHHC17
ZNF135
34 interacting genes:
ACACA
ANXA7
APP
ATXN2
CBFB
CCDC92
CDKN1A
FGFR3
LRRK1
LRRK2
MARK3
MFHAS1
MGLL
MOGS
OGG1
PKN2
POLD1
POLR2E
PRAG1
PTEN
RAC2
RAP1B
RCC1
RXRG
S100A8
SAFB2
SLC25A6
TAZ
TK1
TUBB2A
TWF2
UBQLN1
UBTF
YLPM1
Entrez ID
5908
1114
HPRD ID
01546
07512
Ensembl ID
ENSG00000127314
ENSG00000089199
Uniprot IDs
A0A024RB87
B7ZAY2
P61224
P05060
PDB IDs
3BRW
3CF6
4DXA
4HDO
4HDQ
4M8N
4MGI
4MGK
4MGY
4MGZ
4MH0
5KHO
6AXF
6BA6
6KYK
6OQ3
6OQ4
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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