RAD9A and MSH3

Data Source:
BioGRID (far western blotting)

		RAD9A	MSH3
Description		RAD9 checkpoint clamp component A	mutS homolog 3
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Checkpoint Clamp Complex	Nucleus Nucleoplasm Membrane Mismatch Repair Complex MutSbeta Complex
	Molecular Function	Protein Binding 3'-5' Exonuclease Activity Exodeoxyribonuclease III Activity SH3 Domain Binding Enzyme Binding Protein Kinase Binding Histone Deacetylase Binding	Single-stranded DNA Binding Protein Binding ATP Binding DNA-dependent ATPase Activity Enzyme Binding Mismatched DNA Binding DNA Insertion Or Deletion Binding Guanine/thymine Mispair Binding Dinucleotide Insertion Or Deletion Binding Single Guanine Insertion Binding Dinucleotide Repeat Insertion Binding Oxidized Purine DNA Binding Protein Homodimerization Activity
	Biological Process	DNA Replication Checkpoint DNA Damage Checkpoint DNA Replication DNA Repair Cellular Response To DNA Damage Stimulus Intra-S DNA Damage Checkpoint Cellular Response To Ionizing Radiation Nucleic Acid Phosphodiester Bond Hydrolysis Regulation Of Signal Transduction By P53 Class Mediator	Meiotic Mismatch Repair Removal Of Nonhomologous Ends DNA Repair Mismatch Repair Mitotic Recombination Reciprocal Meiotic Recombination Somatic Recombination Of Immunoglobulin Gene Segments Replication Fork Arrest Maintenance Of DNA Repeat Elements Negative Regulation Of DNA Recombination Positive Regulation Of Helicase Activity
Pathways		Activation of ATR in response to replication stress HDR through Single Strand Annealing (SSA) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint	Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Defective Mismatch Repair Associated With MSH3 Defective Mismatch Repair Associated With MSH2
Drugs
Diseases			Colorectal cancer
GWAS		Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634)	Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) HDL cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931) Huntington's disease progression ( 28642124) Idiopathic downbeat nystagmus ( 32157568) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		38 interacting genes: ABL1 AR ATAD5 ATM BCL2 BCL2L1 CAD CHEK2 CLSPN COPS5 CSNK2A1 CSNK2A2 DNAJC7 FEM1B FEN1 HDAC1 HUS1 HUS1B ITSN2 MLH1 MSH2 MSH3 MSH6 NR3C1 OGG1 PCNA POLB PRKCE RAD17 RAD9B RHNO1 RPA1 RPA2 SF3B3 TDG TLK1 TOPBP1 WRN	14 interacting genes: BARD1 BRCA1 EXO1 HUS1 MLH1 MSH2 PCNA RAD1 RAD9A RCHY1 RPA4 SUMO2 TSC22D2 XPA
Entrez ID		5883	4437
HPRD ID		04788	02931
Ensembl ID		ENSG00000172613	ENSG00000113318
Uniprot IDs		Q99638	P20585
PDB IDs		3A1J 3G65 3GGR 6HM5 6J8Y	3THW 3THX 3THY 3THZ
Enriched GO Terms of Interacting Partners?
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