RABGGTB and ALAS2

Data Source:
HPRD (in vivo)

		RABGGTB	ALAS2
Description		Rab geranylgeranyltransferase subunit beta	5'-aminolevulinate synthase 2
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GO Annotations	Cellular Component	Cytosol Plasma Membrane Rab-protein Geranylgeranyltransferase Complex	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix
	Molecular Function	Rab Geranylgeranyltransferase Activity Protein Binding Zinc Ion Binding Small GTPase Binding	5-aminolevulinate Synthase Activity Protein Binding Pyridoxal Phosphate Binding
	Biological Process	Cellular Protein Modification Process Visual Perception Protein Phosphopantetheinylation Protein Prenylation Protein Geranylgeranylation Regulation Of Apoptotic Process Post-translational Protein Modification	Response To Hypoxia Protoporphyrinogen IX Biosynthetic Process Heme Biosynthetic Process Cellular Iron Ion Homeostasis Erythrocyte Differentiation Oxygen Homeostasis Hemoglobin Biosynthetic Process Erythrocyte Development
Pathways		TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain RAB geranylgeranylation	Heme biosynthesis
Drugs		N-Formylmethionine Farnesyl diphosphate Geranylgeranyl diphosphate	Pyridoxal phosphate Glycine
Diseases
GWAS		Daytime sleep phenotypes ( 27126917) Serum metabolite levels ( 23093944)	Mean corpuscular hemoglobin ( 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 32888494) Red blood cell count ( 32888494) Red cell distribution width ( 32888494)
Interacting Genes		20 interacting genes: ALAS2 ARAF B4GALT7 CHML IGFBP6 NPSR1 PTP4A2 RAB11A RAB1A RAB27A RAB37 RAB3A RAB5A RAB6A RAB7A RABGGTA SH3GLB1 TAFA1 TMEM25 WDR4	4 interacting genes: BANP GRB2 RABGGTB SUCLA2
Entrez ID		5876	212
HPRD ID		01532	02356
Ensembl ID		ENSG00000137955	ENSG00000158578
Uniprot IDs		A8KAJ2 P53611 Q6IB63	P22557
PDB IDs		6J6X 6J74 6J7F 6J7X 6O60	5QQQ 5QQR 5QQS 5QQT 5QQU 5QQV 5QQW 5QQX 5QQY 5QQZ 5QR0 5QR1 5QR2 5QR3 5QR4 5QR5 5QR6 5QR7 5QR8 5QR9 5QRA 5QRB 5QRC 5QRD 5QRE 5QT3 6HRH
Enriched GO Terms of Interacting Partners?
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