BBS4 and RARG

Data Source:
BioGRID (two hybrid)

		BBS4	RARG
Description		Bardet-Biedl syndrome 4	retinoic acid receptor gamma
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GO Annotations	Cellular Component	Pericentriolar Material Nucleus Centrosome Centriole Cytosol Cilium Motile Cilium Centriolar Satellite BBSome Ciliary Transition Zone Ciliary Basal Body Ciliary Membrane Non-motile Cilium	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Integral Component Of Membrane
	Molecular Function	RNA Polymerase II Repressing Transcription Factor Binding Protein Binding Protein-macromolecule Adaptor Activity Dynactin Binding Alpha-tubulin Binding Beta-tubulin Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Zinc Ion Binding Retinoid X Receptor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Microtubule Cytoskeleton Organization Mitotic Cytokinesis Neural Tube Closure Retina Homeostasis Heart Looping Centrosome Cycle Spermatid Development Visual Perception Sensory Perception Of Smell Protein Transport Dendrite Development Regulation Of Lipid Metabolic Process Striatum Development Hippocampus Development Cerebral Cortex Development Adult Behavior Melanosome Transport Regulation Of Cytokinesis Protein Localization To Organelle Microtubule Anchoring At Centrosome Negative Regulation Of Appetite By Leptin-mediated Signaling Pathway Fat Cell Differentiation Photoreceptor Cell Maintenance Positive Regulation Of Cilium Assembly Retinal Rod Cell Development Intracellular Transport Brain Morphogenesis Sensory Processing Maintenance Of Protein Location In Nucleus Cilium Assembly Regulation Of Cilium Beat Frequency Involved In Ciliary Motility Protein Localization To Cilium Protein Localization To Centrosome Non-motile Cilium Assembly	Negative Regulation Of Transcription By RNA Polymerase II Neural Tube Closure Glandular Epithelial Cell Development Growth Plate Cartilage Chondrocyte Growth Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Regulation Of Cell Size Hormone-mediated Signaling Pathway Anterior/posterior Pattern Specification Cell Differentiation Embryonic Camera-type Eye Development Regulation Of Myelination Negative Regulation Of Chondrocyte Differentiation Response To Retinoic Acid Embryonic Hindlimb Morphogenesis Multicellular Organism Growth Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Myeloid Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Embryonic Eye Morphogenesis Retinoic Acid Receptor Signaling Pathway Canonical Wnt Signaling Pathway Face Development Trachea Cartilage Development Prostate Gland Epithelium Morphogenesis Harderian Gland Development Cellular Response To Retinoic Acid Cellular Response To Leukemia Inhibitory Factor
Pathways		BBSome-mediated cargo-targeting to cilium	Nuclear Receptor transcription pathway Signaling by Retinoic Acid Activation of anterior HOX genes in hindbrain development during early embryogenesis
Drugs			Adapalene Acitretin Alitretinoin Tretinoin Tazarotene Etretinate Isotretinoin SR11254 BMS-181156 CD564 Dodecyl-Alpha-D-Maltoside BMS184394 R667 LGD-1550 3-Fluoro-4-{[(2R)-2-hydroxy-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-2-naphthalenyl)acetyl]amino}benzoic acid 3-fluoro-4-[2-hydroxy-2-(5,5,8,8-tetramethyl-5,6,7,8,-tetrahydro-naphtalen-2-yl)-acetylamino]-benzoic acid Trifarotene
Diseases		Bardet-Biedl syndrome (BBS)
GWAS		Body mass index ( 29273807 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically active individuals ( 28448500) Theory of mind score in adolescence (Emotional Triangles Task) ( 29472613) Triglycerides ( 30275531) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Anthracycline-induced cardiotoxicity in childhood cancer ( 26237429) Cardiorespiratory fitness (800m run time) ( 32572135) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203)
Interacting Genes		21 interacting genes: ACTB BHMT C2CD6 CALCA DCTN1 EEF1A1 EIF3A EPAS1 EXOC7 FHOD1 HSCB KRT18 MYOG OAS1 PAX2 PCM1 RARA RARG REL SPIRE1 ZIC1	33 interacting genes: ACY3 ARID1A BBS4 HMGA1 IL24 ITGB1BP2 LSR MAP6 MRPL12 MTMR6 MYF5 NCOA1 NCOA3 NCOR1 NCOR2 NKX3-1 NR0B2 NR2F6 OIP5 PNRC1 PNRC2 PRKAR1B PSMC5 RHPN2 RXRA RXRB RXRG S100A3 SMAD3 SMARCD3 SPHK1 TNIP1 ZNF576
Entrez ID		585	5916
HPRD ID		08982	01573
Ensembl ID		ENSG00000140463	ENSG00000172819
Uniprot IDs		A0A0S2Z3A9 Q96RK4	A8K3H3 B7Z4B4 F1D8P1 P13631
PDB IDs		6XT9	1EXA 1EXX 1FCX 1FCY 1FCZ 1FD0 2LBD 3LBD 4LBD 5M24 6FX0
Enriched GO Terms of Interacting Partners?
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