PYCR1 and HNRNPD

Data Source:
BioGRID (two hybrid)

		PYCR1	HNRNPD
Description		pyrroline-5-carboxylate reductase 1	heterogeneous nuclear ribonucleoprotein D
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix	Nucleus Nucleoplasm Cytosol Synapse Ribonucleoprotein Complex
	Molecular Function	Pyrroline-5-carboxylate Reductase Activity Protein Binding Identical Protein Binding	Minor Groove Of Adenine-thymine-rich DNA Binding Chromatin Binding RNA Binding Protein Binding Transcription Factor Binding MRNA 3'-UTR AU-rich Region Binding Telomeric DNA Binding Histone Deacetylase Binding
	Biological Process	Proline Biosynthetic Process Cellular Amino Acid Biosynthetic Process Cellular Response To Oxidative Stress Regulation Of Mitochondrial Membrane Potential L-proline Biosynthetic Process Negative Regulation Of Hydrogen Peroxide-induced Cell Death	MRNA Splicing, Via Spliceosome Liver Development Regulation Of Transcription, DNA-templated RNA Processing RNA Catabolic Process Regulation Of Gene Expression RNA Metabolic Process Cerebellum Development Regulation Of Telomere Maintenance Regulation Of Circadian Rhythm Regulation Of MRNA Stability Positive Regulation Of Translation Positive Regulation Of Transcription, DNA-templated MRNA Stabilization Response To Calcium Ion Response To Electrical Stimulus 3'-UTR-mediated MRNA Destabilization Cellular Response To Amino Acid Stimulus Cellular Response To Estradiol Stimulus Cellular Response To Nitric Oxide Circadian Regulation Of Translation Response To Rapamycin Positive Regulation Of Telomere Capping Response To Sodium Phosphate Cellular Response To Putrescine Positive Regulation Of Telomerase RNA Reverse Transcriptase Activity Hepatocyte Dedifferentiation
Pathways		Glutamate and glutamine metabolism	mRNA Splicing - Major Pathway Processing of Capped Intron-Containing Pre-mRNA
Drugs		NADH Proline	Artenimol
Diseases		Geroderma osteodysplasticum
GWAS			Chronotype ( 30696823) Coronary artery disease ( 32469254 33020668) Morning person ( 30696823) Refractive error ( 32231278)
Interacting Genes		6 interacting genes: BNIPL CDK2AP2 HNRNPD NUDT21 SIRT3 TNPO2	87 interacting genes: ABCC10 ACTB ADGRE5 ARF4 B3GAT3 BCL2 BET1L BRCA1 C1QBP CAPN1 CD81 CINP COG7 COL18A1 CSDE1 CTSB CUTA DGCR2 DHX30 DMAC1 EEF2 ERG ESR1 EXOSC4 FBXL15 FLNA GSK3B GTF3C3 GTSE1 GUK1 HBZ HDAC1 HIRA HMGA1 HNRNPF HNRNPH3 HSPA4 HSPB1 HSPB2 IGF2BP2 IL7R IMMP2L IMMT ING4 LDHA LSM5 MAP2K1 MAPK6 MEOX2 MPP1 MTA2 NTMT1 P4HB PABPC1 PCBP1 PCBP2 PCSK7 PDLIM7 PEX10 PPOX PRDX3 PRKACA PTBP2 PYCR1 RALY RPSA SAFB SDF2 SEPTIN9 SF3B4 SFN SHISA5 SLC27A5 SLC3A2 SNAPC4 SNRPC SREK1 SUMO4 SYNCRIP TNPO1 TRN-GTT2-7 TSEN34 UBE2I UQCRC1 VEGFA VHL YBX1
Entrez ID		5831	3184
HPRD ID		01528	03206
Ensembl ID		ENSG00000183010	ENSG00000138668
Uniprot IDs		A0A024R8U9 E2QRB3 J3QL32 P32322 Q8TBX0	A0A024RDB4 A0A024RDF4 A1LU37 Q14103
PDB IDs		2GER 2GR9 2GRA 2IZZ 5UAT 5UAU 5UAV 5UAW 5UAX 6XOZ 6XP0 6XP1 6XP2 6XP3	1HD0 1HD1 1IQT 1WTB 1X0F 2Z5N 5IM0
Enriched GO Terms of Interacting Partners?
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