NEUROD4 and RNF41

Data Source:
BioGRID (two hybrid, imaging technique)

		NEUROD4	RNF41
Description		neuronal differentiation 4	ring finger protein 41
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Cytosol Perinuclear Region Of Cytoplasm Endoplasmic Reticulum Tubular Network
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Binding Protein Dimerization Activity	Ubiquitin-protein Transferase Activity Erythropoietin Receptor Binding Interleukin-3 Receptor Binding Protein Binding Zinc Ion Binding Protein Domain Specific Binding Receptor Tyrosine Kinase Binding Small GTPase Binding Identical Protein Binding Ubiquitin Protein Ligase Activity
	Biological Process	Regulation Of Transcription By RNA Polymerase II Neuron Differentiation Amacrine Cell Differentiation Positive Regulation Of Cell Differentiation Neuron Development	Protein Polyubiquitination Autophagy Negative Regulation Of Cell Population Proliferation Proteasomal Protein Catabolic Process Protein Ubiquitination Negative Regulation Of Cell Migration Regulation Of MAPK Cascade Regulation Of Lymphocyte Differentiation Regulation Of Myeloid Cell Differentiation Positive Regulation Of Protein Catabolic Process Positive Regulation Of DNA-binding Transcription Factor Activity Protein Autoubiquitination Regulation Of Protein Kinase B Signaling Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Mitophagy Regulation Of Establishment Of Cell Polarity Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process
Pathways			Downregulation of ERBB2:ERBB3 signaling Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Asthma (childhood onset) ( 31036433) Lead levels ( 26025379) Refractive error ( 32231278) Severe influenza A (H1N1) infection ( 26379185) Spontaneous preterm birth without premature rupture of membranes ( 31194736)	Asthma ( 31619474)
Interacting Genes		5 interacting genes: GABRB1 LRRN2 MAGEB4 PIN1 TCF4	42 interacting genes: ADRB2 AP2S1 APP ARL6IP4 ASB6 BIRC6 C1orf109 ENOPH1 ERBB3 ERBB4 IRS4 ISCA2 KDM3B LEPR LZTS2 MAGEL2 MARK2 MEOX2 MNAT1 MTNR1A MTNR1B MTURN N4BP3 RAD23A RFC4 RNF166 RRM2B SRR TCEANC TRIM32 TRIM8 TSG101 TTC1 UBASH3A UBASH3B UBE2D3 UBE2K UBE2U UBE2Z USP8 VPS52 ZAP70
Entrez ID		58158	10193
HPRD ID		14826	11520
Ensembl ID		ENSG00000123307	ENSG00000181852
Uniprot IDs		Q8IW56 Q9HD90	A0A024RB33 Q9H4P4
PDB IDs			2FZP 2GWF
Enriched GO Terms of Interacting Partners?
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