RNF41 and TTC1

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		RNF41	TTC1
Description		ring finger protein 41	tetratricopeptide repeat domain 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Perinuclear Region Of Cytoplasm Endoplasmic Reticulum Tubular Network	Peroxisomal Membrane Cytosol
	Molecular Function	Ubiquitin-protein Transferase Activity Erythropoietin Receptor Binding Interleukin-3 Receptor Binding Protein Binding Zinc Ion Binding Protein Domain Specific Binding Receptor Tyrosine Kinase Binding Small GTPase Binding Identical Protein Binding Ubiquitin Protein Ligase Activity	Protein Binding Unfolded Protein Binding
	Biological Process	Protein Polyubiquitination Autophagy Negative Regulation Of Cell Population Proliferation Proteasomal Protein Catabolic Process Protein Ubiquitination Negative Regulation Of Cell Migration Regulation Of MAPK Cascade Regulation Of Lymphocyte Differentiation Regulation Of Myeloid Cell Differentiation Positive Regulation Of Protein Catabolic Process Positive Regulation Of DNA-binding Transcription Factor Activity Protein Autoubiquitination Regulation Of Protein Kinase B Signaling Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Mitophagy Regulation Of Establishment Of Cell Polarity Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process	Protein Folding
Pathways		Downregulation of ERBB2:ERBB3 signaling Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Asthma ( 31619474)	Diastolic blood pressure ( 27841878) Hemoglobin levels ( 32327693) Pulse pressure ( 27841878) Systolic blood pressure ( 27841878)
Interacting Genes		42 interacting genes: ADRB2 AP2S1 APP ARL6IP4 ASB6 BIRC6 C1orf109 ENOPH1 ERBB3 ERBB4 IRS4 ISCA2 KDM3B LEPR LZTS2 MAGEL2 MARK2 MEOX2 MNAT1 MTNR1A MTNR1B MTURN N4BP3 RAD23A RFC4 RNF166 RRM2B SRR TCEANC TRIM32 TRIM8 TSG101 TTC1 UBASH3A UBASH3B UBE2D3 UBE2K UBE2U UBE2Z USP8 VPS52 ZAP70	19 interacting genes: ACY1 CRY2 CYB5R1 GNA15 GNAI2 GNAQ GNAS HRAS HSPA1A HSPA4 HSPA8 NDE1 PSTPIP1 RNF41 SH3BP4 SOX5 SPP1 SREBF2 TGFBR1
Entrez ID		10193	7265
HPRD ID		11520	11881
Ensembl ID		ENSG00000181852	ENSG00000113312
Uniprot IDs		A0A024RB33 Q9H4P4	Q99614
PDB IDs		2FZP 2GWF
Enriched GO Terms of Interacting Partners?
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