PTS and PRKG2

Data Source:
HPRD (in vivo, in vitro)

		PTS	PRKG2
Description		6-pyruvoyltetrahydropterin synthase	protein kinase cGMP-dependent 2
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GO Annotations	Cellular Component	Cytoplasm Mitochondrion Cytosol	Cytosol Apical Plasma Membrane Nuclear Membrane
	Molecular Function	6-pyruvoyltetrahydropterin Synthase Activity Protein Binding Identical Protein Binding Metal Ion Binding	Protein Kinase Activity CGMP-dependent Protein Kinase Activity ATP Binding CGMP Binding Identical Protein Binding
	Biological Process	Cellular Amino Acid Metabolic Process Tetrahydrobiopterin Biosynthetic Process Central Nervous System Development	Protein Phosphorylation Signal Transduction Peptidyl-serine Autophosphorylation Protein Localization To Plasma Membrane Negative Regulation Of Chloride Transport
Pathways		Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation Ca2+ pathway cGMP effects cGMP effects RAS processing
Drugs		Mycophenolate mofetil Biopterin	Fostamatinib
Diseases		Phenylketonuria (PKU); Hyperphenylalaninemia, BH4-deficient
GWAS		Heel bone mineral density ( 30598549) Objective response to lithium treatment ( 26503763)	Blood pressure (smoking interaction) ( 25189868) Body size at age 10 ( 32376654) Height ( 28552196 25282103 19343178 23563607 31562340 18391951) Hip circumference adjusted for BMI ( 25673412) HIV-1 susceptibility ( 22174851) Pubertal anthropometrics ( 23449627) Refractive error ( 32231278) Sleep duration (short sleep) ( 30846698) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412 28448500)
Interacting Genes		11 interacting genes: AP2M1 COIL DDIT4L FNDC5 FXR2 LNX1 NTAQ1 PBRM1 PRKG2 SDCBP THAP10	7 interacting genes: FBXO25 LASP1 MYLK NEDD4 PLCB3 PTS WDR77
Entrez ID		5805	5593
HPRD ID		11840	09034
Ensembl ID		ENSG00000150787	ENSG00000138669
Uniprot IDs		Q03393	A0A140VJM3 B4DLF9 B7ZA25 Q13237
PDB IDs		3I2B	5BV6 5C6C 5C8W 5JIX 5JIZ 6BQ8
Enriched GO Terms of Interacting Partners?
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