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PTPRJ and PDGFRB
Data Source:
HPRD
(in vivo, in vitro)
PTPRJ
PDGFRB
Description
protein tyrosine phosphatase receptor type J
platelet derived growth factor receptor beta
Image
GO Annotations
Cellular Component
Immunological Synapse
Plasma Membrane
Integral Component Of Plasma Membrane
Cell-cell Junction
Cell Surface
Ruffle Membrane
Specific Granule Membrane
Extracellular Exosome
Nucleus
Cytoplasm
Golgi Apparatus
Plasma Membrane
Integral Component Of Plasma Membrane
Focal Adhesion
Cell Surface
Membrane
Apical Plasma Membrane
Intrinsic Component Of Plasma Membrane
Cytoplasmic Vesicle
Lysosomal Lumen
Intracellular Membrane-bounded Organelle
Receptor Complex
Molecular Function
Protein Tyrosine Phosphatase Activity
Platelet-derived Growth Factor Receptor Binding
Protein Binding
Beta-catenin Binding
Phosphatase Activity
Protein Kinase Binding
Gamma-catenin Binding
Cadherin Binding
Mitogen-activated Protein Kinase Binding
Delta-catenin Binding
Protein Tyrosine Kinase Activity
Transmembrane Receptor Protein Tyrosine Kinase Activity
Platelet Activating Factor Receptor Activity
Platelet-derived Growth Factor-activated Receptor Activity
Platelet-derived Growth Factor Beta-receptor Activity
Signaling Receptor Binding
Platelet-derived Growth Factor Receptor Binding
Protein Binding
ATP Binding
Growth Factor Binding
Enzyme Binding
Protein Kinase Binding
Vascular Endothelial Growth Factor Binding
Phosphatidylinositol 3-kinase Binding
Platelet-derived Growth Factor Binding
Biological Process
Protein Dephosphorylation
Negative Regulation Of Cell Population Proliferation
Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway
Regulation Of Cell Adhesion
B Cell Differentiation
Negative Regulation Of Cell Growth
Negative Regulation Of Cell Migration
Positive Regulation Of Tumor Necrosis Factor Production
Peptidyl-tyrosine Dephosphorylation
Calcium-mediated Signaling Using Intracellular Calcium Source
Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Negative Regulation Of Vascular Permeability
Neutrophil Degranulation
Negative Regulation Of MAP Kinase Activity
Positive Regulation Of MAPK Cascade
Positive Regulation Of Cell Adhesion
Platelet-derived Growth Factor Receptor Signaling Pathway
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
T Cell Receptor Signaling Pathway
Negative Regulation Of T Cell Receptor Signaling Pathway
Positive Chemotaxis
Positive Regulation Of Focal Adhesion Assembly
Positive Regulation Of Protein Kinase B Signaling
Negative Regulation Of Protein Kinase B Signaling
Contact Inhibition
Positive Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
MAPK Cascade
Glycosaminoglycan Biosynthetic Process
Signal Transduction
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
G Protein-coupled Receptor Signaling Pathway
Multicellular Organism Development
Aging
Positive Regulation Of Cell Population Proliferation
Male Gonad Development
Response To Toxic Substance
Positive Regulation Of Phospholipase C Activity
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Positive Regulation Of Smooth Muscle Cell Migration
Cell Migration
Peptidyl-tyrosine Phosphorylation
Positive Regulation Of Cell Migration
Response To Estradiol
Positive Regulation Of Phosphoprotein Phosphatase Activity
Response To Retinoic Acid
Regulation Of Actin Cytoskeleton Organization
Positive Regulation Of Collagen Biosynthetic Process
Positive Regulation Of Kinase Activity
Response To Fluid Shear Stress
Positive Regulation Of Rho Protein Signal Transduction
Cell Migration Involved In Vasculogenesis
Metanephric Mesenchymal Cell Migration
Platelet-derived Growth Factor Receptor-beta Signaling Pathway
Positive Regulation Of Metanephric Mesenchymal Cell Migration By Platelet-derived Growth Factor Receptor-beta Signaling Pathway
Aorta Morphogenesis
Cellular Response To Platelet-derived Growth Factor Stimulus
Positive Regulation Of Cell Proliferation By VEGF-activated Platelet Derived Growth Factor Receptor Signaling Pathway
Wound Healing
Response To Hydrogen Peroxide
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Positive Regulation Of MAP Kinase Activity
Positive Regulation Of Phosphatidylinositol 3-kinase Activity
Response To Estrogen
Positive Regulation Of Mitotic Nuclear Division
Phosphatidylinositol Metabolic Process
Protein Autophosphorylation
Platelet-derived Growth Factor Receptor Signaling Pathway
Phosphatidylinositol-mediated Signaling
Positive Regulation Of Fibroblast Proliferation
Positive Regulation Of Smooth Muscle Cell Proliferation
Inner Ear Development
Positive Regulation Of Chemotaxis
Positive Regulation Of Protein Kinase B Signaling
Cardiac Myofibril Assembly
Response To Hyperoxia
Cell Chemotaxis
Lung Growth
Cell Migration Involved In Coronary Angiogenesis
Retina Vasculature Development In Camera-type Eye
Positive Regulation Of ERK1 And ERK2 Cascade
Smooth Muscle Cell Chemotaxis
Metanephric Mesenchyme Development
Metanephric Glomerular Mesangial Cell Proliferation Involved In Metanephros Development
Metanephric Glomerular Capillary Formation
Metanephric Comma-shaped Body Morphogenesis
Metanephric S-shaped Body Morphogenesis
Positive Regulation Of Calcium Ion Import
Positive Regulation Of Reactive Oxygen Species Metabolic Process
Positive Regulation Of Hepatic Stellate Cell Activation
Positive Regulation Of DNA Biosynthetic Process
Pathways
Phosphorylation of CD3 and TCR zeta chains
Neutrophil degranulation
Negative regulation of MET activity
Negative regulation of FLT3
PIP3 activates AKT signaling
Downstream signal transduction
Signaling by PDGF
Constitutive Signaling by Aberrant PI3K in Cancer
RAF/MAP kinase cascade
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Drugs
Becaplermin
Sorafenib
Imatinib
Dasatinib
Sunitinib
XL999
XL820
Pazopanib
Midostaurin
Regorafenib
Nintedanib
Polaprezinc
Trapidil
Foreskin fibroblast (neonatal)
Fostamatinib
Erdafitinib
Pexidartinib
Ripretinib
Pralsetinib
Diseases
Glioma
GWAS
Acute lymphoblastic leukemia (childhood) (
22076464
)
Alzheimer's disease or fasting glucose levels (pleiotropy) (
30805717
)
Blood protein levels (
30072576
)
D-dimer levels (
21502573
)
Experiencing mood swings (
29500382
)
Heel bone mineral density (
30598549
)
Height (
28552196
25282103
23563607
)
High light scatter reticulocyte count (
32888494
)
High light scatter reticulocyte percentage of red cells (
32888494
)
Hypertension (
31879980
)
Intraocular pressure (
29617998
25173106
31798171
29785010
31959993
30054594
29235454
)
Lymphocyte counts (
32888494
)
Mean platelet volume (
32888494
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Monocyte count (
32888494
)
Offspring birth weight (
31043758
)
Refractive error (
32231278
)
Sleep duration (short sleep) (
30846698
)
Blood protein levels (
30072576
29875488
28240269
)
Cytokine network levels (multivariate analysis) (
31679650
)
Granulocyte percentage of myeloid white cells (
27863252
)
Inflammatory biomarkers (multivariate analysis) (
33110245
)
Monocyte count (
27863252
)
Monocyte percentage of white cells (
32888494
27863252
)
Interacting Genes
36 interacting genes:
ANP32B
BAAT
BAP1
CASC3
CTNNB1
CTNND1
CYP17A1
EGFR
EPSTI1
FANCC
FBP1
HEMGN
HOXC6
HRAS
IL2RG
JUP
KLK7
KLK9
LAT
LYPD3
MAP2K1
MET
NANS
NOP2
PDGFRB
PLCG1
PPP2CB
PPP3R2
PRDM14
RASA1
SDCBP
SFRP4
TMEFF1
TRMO
TSTD2
ZNF510
76 interacting genes:
ABL1
ABL2
ARAF
BAG1
CAV1
CAV3
CBL
CEP76
COPA
COPB1
CRK
EGFR
EIF2AK2
ERBB2
FGFR1
FYN
GAB1
GRB10
GRB14
GRB2
GRB7
ITGB3
JAK1
JAK2
KLHL12
KPRP
KRT31
KRT34
KRTAP10-9
KRTAP12-3
KRTAP4-12
NCK1
NCK2
NEDD4
PDAP1
PDGFB
PDGFD
PDGFRA
PIK3C2B
PIK3CA
PIK3R1
PIK3R2
PIK3R3
PLCG1
PPM1L
PRDX2
PTEN
PTK2
PTPN1
PTPN11
PTPN2
PTPN6
PTPRJ
RAF1
RASA1
RPS6KB2
S1PR1
SHC1
SLC9A3R1
SLC9A3R2
SNX1
SNX2
SNX4
SOCS1
SRC
STAT1
STAT3
STAT5A
STAT5B
SYNGAP1
TNK2
TPTE
TRIP6
TYK2
VAV1
YES1
Entrez ID
5795
5159
HPRD ID
02955
01423
Ensembl ID
ENSG00000149177
ENSG00000113721
Uniprot IDs
Q12913
Q9NPR5
P09619
Q59F04
PDB IDs
2CFV
2DLE
2NZ6
1GQ5
1H9O
1LWP
1SHA
2IUI
2L6W
2PLD
2PLE
3MJG
Enriched GO Terms of Interacting Partners
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