CHD8 and CHD7

Data Source:
BioGRID (two hybrid, two hybrid)

		CHD8	CHD7
Description		chromodomain helicase DNA binding protein 8	chromodomain helicase DNA binding protein 7
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Protein-containing Complex MLL1 Complex	Nucleus Nucleoplasm Nucleolus
	Molecular Function	P53 Binding DNA Binding DNA Helicase Activity Chromatin Binding Protein Binding ATP Binding Beta-catenin Binding DNA-dependent ATPase Activity Methylated Histone Binding Histone Binding Armadillo Repeat Domain Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA Helicase Activity Chromatin Binding Protein Binding ATP Binding Promoter-specific Chromatin Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Brain Development Wnt Signaling Pathway DNA Duplex Unwinding Social Behavior ATP-dependent Chromatin Remodeling Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase III Digestive Tract Development Prepulse Inhibition Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Fibroblast Apoptotic Process	Skeletal System Development In Utero Embryonic Development Blood Vessel Remodeling Heart Morphogenesis Ventricular Trabecula Myocardium Morphogenesis Right Ventricular Compact Myocardium Morphogenesis Chromatin Remodeling Regulation Of Transcription, DNA-templated RRNA Processing Central Nervous System Development Adult Heart Development Sensory Perception Of Sound Adult Walking Behavior Blood Circulation Response To Bacterium Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Cranial Nerve Development Olfactory Nerve Development Olfactory Bulb Development T Cell Differentiation Female Genitalia Development DNA Duplex Unwinding Embryonic Hindlimb Morphogenesis Aorta Morphogenesis Atrioventricular Canal Development Positive Regulation Of Multicellular Organism Growth Olfactory Behavior Inner Ear Morphogenesis Nose Development Positive Regulation Of Transcription By RNA Polymerase II Semicircular Canal Morphogenesis Genitalia Development Regulation Of Neurogenesis Cognition Retina Development In Camera-type Eye Regulation Of Growth Hormone Secretion Limb Development Face Development Innervation Cardiac Septum Morphogenesis Epithelium Development Secondary Palate Development
Pathways		Deactivation of the beta-catenin transactivating complex
Drugs
Diseases			Hypogonadotropic hypogonadism; Kallmann syndrome (KAL) CHARGE syndrome
GWAS		Height ( 31562340)	Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 32888494 27863252) Eosinophil counts ( 29403010 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Height ( 28552196) Lymphocyte percentage of white cells ( 32888494 27863252) Menopause (age at onset) ( 26414677) Monocyte percentage of white cells ( 32888494 27863252) Multiple sclerosis ( 31604244) Myeloid white cell count ( 27863252) Neutrophil count ( 29403010 32888494 27863252) Neutrophil percentage of granulocytes ( 27863252) Neutrophil percentage of white cells ( 32888494 27863252) Pulmonary function decline ( 22424883) Refractive error ( 23396134 32231278) Sum basophil neutrophil counts ( 27863252) Sum eosinophil basophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Systemic sclerosis ( 31672989) Urinary albumin excretion (no hypertensive medication) ( 30220432) Urinary albumin-to-creatinine ratio ( 31511532) White blood cell count ( 29403010 32888494 27863252)
Interacting Genes		11 interacting genes: AR ASH2L CHD7 CREB1 CTCF CTNNB1 RBBP5 RCHY1 SUMO2 TOP3B WDR5	2 interacting genes: CHD8 CTCF
Entrez ID		57680	55636
HPRD ID		16712	10595
Ensembl ID		ENSG00000100888	ENSG00000171316
Uniprot IDs		Q9HCK8	Q6ZWF9 Q9P2D1
PDB IDs		2CKA 2DL6	2CKC 2V0E 2V0F
Enriched GO Terms of Interacting Partners?
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