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ZBTB2 and SP1
Data Source:
BioGRID
(pull down)
ZBTB2
SP1
Description
zinc finger and BTB domain containing 2
Sp1 transcription factor
Image
No pdb structure
GO Annotations
Cellular Component
Nucleoplasm
Chromatin
Euchromatin
Nucleus
Nucleoplasm
Cytoplasm
Transcription Repressor Complex
Protein-DNA Complex
Molecular Function
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
Protein Binding
Identical Protein Binding
Metal Ion Binding
Sequence-specific Double-stranded DNA Binding
Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Cis-regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Repressing Transcription Factor Binding
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
Double-stranded DNA Binding
DNA-binding Transcription Factor Activity
Protein Binding
Protein C-terminus Binding
Transcription Factor Binding
Histone Acetyltransferase Binding
Protein Homodimerization Activity
Histone Deacetylase Binding
BHLH Transcription Factor Binding
Sequence-specific DNA Binding
Metal Ion Binding
Repressing Transcription Factor Binding
HMG Box Domain Binding
Sequence-specific Double-stranded DNA Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of Transcription By RNA Polymerase II
Regulation Of Transcription, DNA-templated
Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Gene Expression
Viral Process
Cellular Response To Insulin Stimulus
Response To Hydroperoxide
SnRNA Transcription By RNA Polymerase II
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Positive Regulation By Host Of Viral Transcription
Regulation Of Cholesterol Biosynthetic Process
Positive Regulation Of Angiogenesis
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Rhythmic Process
Positive Regulation Of Amyloid-beta Formation
Positive Regulation Of Hydrogen Sulfide Biosynthetic Process
Positive Regulation Of Vascular Endothelial Cell Proliferation
Pathways
PPARA activates gene expression
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
Activation of gene expression by SREBF (SREBP)
Oncogene Induced Senescence
RNA polymerase II transcribes snRNA genes
RNA polymerase II transcribes snRNA genes
Estrogen-dependent gene expression
Drugs
Diseases
GWAS
Chronic myeloid leukemia (
21540461
)
Refractive error (
32231278
)
Apolipoprotein B levels (
32203549
)
High light scatter reticulocyte count (
32888494
)
Hypospadias (moderate to severe) (
31856834
)
Mean corpuscular hemoglobin (
29403010
)
Mean corpuscular volume (
29403010
32888494
)
Mean spheric corpuscular volume (
32888494
)
Neutrophil percentage of white cells (
27863252
)
Parkinsonism in frontotemporal lobe dementia (
29724592
)
Percentage gas trapping (
26030696
)
Progressive supranuclear palsy (
30089514
)
Red blood cell count (
32888494
27863252
)
Reticulocyte count (
32888494
27863252
)
Reticulocyte fraction of red cells (
32888494
)
Interacting Genes
28 interacting genes:
CREBBP
DAXX
GABARAPL2
IP6K2
KAT5
LHX4
LNX1
MEOX2
MKLN1
MOS
MRPL11
PICK1
PIN1
RASSF8
SP1
STAT6
SUMO1
SUMO2
SUV39H1
TENT5B
TMC6
TP53
UBE2I
ZBTB18
ZBTB25
ZBTB49
ZMYND19
ZNF639
146 interacting genes:
AATF
AHR
AKT1
AR
ARHGAP21
ARNT
ATF7IP
ATF7IP2
BCL11B
BCL6
BCOR
BRCA1
CASP3
CASP6
CASP7
CBX5
CCNA1
CCNA2
CCND1
CD2
CDK1
CDK2
CEBPB
CSNK2A1
CTCFL
CTNNB1
DDX5
DROSHA
E2F1
E2F2
E2F3
EGR1
ELF1
EP300
ESR1
ESR2
ESRRA
ESRRB
ESRRG
ETS1
GABPA
GATA1
GATA3
GATA4
HBZ
HCFC1
HDAC1
HDAC2
HIF1A
HINT1
HLTF
HMGA1
HNF4A
HOXC11
HSPA8
HTT
IL1B
JUN
KIF1A
KLF10
KLF4
KLF6
LDB1
LMO2
MAPK1
MAPK3
MAPK8
MBD1
MEF2C
MEF2D
MIER1
MIS18BP1
MSX1
MTREX
MYC
MYCN
MYOD1
MYOG
NAP1L1
NCOR1
NCOR2
NEPRO
NFKB1
NFKB2
NFYA
NFYB
NFYC
NKX3-1
NOS3
NPM1
NR2F1
NR5A1
NUP62
OGT
PARP1
PER3
PML
POGZ
POU2F1
PPIG
PPP1R13L
PRKCZ
PRKDC
PSIP1
PSMC5
PURA
RARA
RB1
RBBP4
RBL1
REL
RELA
RNF4
RORA
RXRA
SENP6
SF3A1
SHC1
SMAD2
SMAD3
SMAD4
SMARCC1
SMARCC2
SOX10
SOX8
SP3
SP4
SREBF1
SREBF2
SRF
SUB1
SUMO2
TAF4
TAL1
TBP
TLX3
TP53
TP73
TPI1
USP39
VEGFA
VHL
YY1
ZBTB16
ZBTB2
ZBTB7A
Entrez ID
57621
6667
HPRD ID
10314
01796
Ensembl ID
ENSG00000181472
ENSG00000185591
Uniprot IDs
Q8N680
P08047
PDB IDs
1SP1
1SP2
1VA1
1VA2
1VA3
6PV0
6PV1
6PV2
6PV3
6UCO
6UCP
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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