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MTA3 and NOTCH2
Data Source:
BioGRID
(two hybrid)
MTA3
NOTCH2
Description
metastasis associated 1 family member 3
notch receptor 2
Image
No pdb structure
GO Annotations
Cellular Component
Nucleoplasm
Cytoplasm
NuRD Complex
Intracellular Membrane-bounded Organelle
Golgi Membrane
Extracellular Region
Nucleus
Nucleoplasm
Endoplasmic Reticulum Membrane
Plasma Membrane
Integral Component Of Plasma Membrane
Cilium
Cell Surface
Membrane
Receptor Complex
Molecular Function
RNA Polymerase II Repressing Transcription Factor Binding
Chromatin Binding
Transcription Coactivator Activity
Transcription Corepressor Activity
Protein Binding
Zinc Ion Binding
Histone Deacetylase Binding
Sequence-specific DNA Binding
Protein-containing Complex Binding
Calcium Ion Binding
Protein Binding
Enzyme Binding
Signaling Receptor Activity
NF-kappaB Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Cell Population Proliferation
Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle
Histone Deacetylation
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Negative Regulation Of Transcription By RNA Polymerase II
In Utero Embryonic Development
Cell Fate Determination
Heart Looping
Morphogenesis Of An Epithelial Sheet
Marginal Zone B Cell Differentiation
Inflammatory Response To Antigenic Stimulus
Pulmonary Valve Morphogenesis
Transcription Initiation From RNA Polymerase II Promoter
Apoptotic Process
Humoral Immune Response
Cell Cycle Arrest
Notch Signaling Pathway
Multicellular Organism Development
Nervous System Development
Axon Guidance
Animal Organ Morphogenesis
Negative Regulation Of Gene Expression
Positive Regulation Of Keratinocyte Proliferation
Stem Cell Population Maintenance
Hemopoiesis
Embryonic Limb Morphogenesis
Positive Regulation Of BMP Signaling Pathway
Multicellular Organism Growth
Intrahepatic Bile Duct Development
Wound Healing
Defense Response To Bacterium
Myeloid Dendritic Cell Differentiation
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Positive Regulation Of Osteoclast Differentiation
Negative Regulation Of Growth Rate
Positive Regulation Of Ras Protein Signal Transduction
Bone Remodeling
Atrial Septum Morphogenesis
Placenta Blood Vessel Development
Ciliary Body Morphogenesis
Notch Signaling Involved In Heart Development
Positive Regulation Of ERK1 And ERK2 Cascade
Left/right Axis Specification
Proximal Tubule Development
Glomerular Visceral Epithelial Cell Development
Glomerular Capillary Formation
Hepatocyte Proliferation
Cholangiocyte Proliferation
Regulation Of Actin Cytoskeleton Reorganization
Regulation Of Osteoclast Development
Pathways
HDACs deacetylate histones
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
RNA Polymerase I Transcription Initiation
Regulation of PTEN gene transcription
Regulation of PTEN gene transcription
Potential therapeutics for SARS
Pre-NOTCH Processing in the Endoplasmic Reticulum
Pre-NOTCH Transcription and Translation
Pre-NOTCH Processing in Golgi
Pre-NOTCH Processing in Golgi
NOTCH2 intracellular domain regulates transcription
NOTCH2 intracellular domain regulates transcription
NOTCH2 Activation and Transmission of Signal to the Nucleus
NOTCH2 Activation and Transmission of Signal to the Nucleus
Notch-HLH transcription pathway
Defective LFNG causes SCDO3
NOTCH4 Intracellular Domain Regulates Transcription
Drugs
Diseases
Alagille syndrome
Type II diabetes mellitus
Hajdu-Cheney syndrome
GWAS
Breastfeeding duration (
25475840
)
Blood protein levels (
30072576
)
Hepatocyte growth factor levels (
25998175
)
Nevus count or cutaneous melanoma (
32341527
)
Systemic lupus erythematosus (
28714469
)
Type 2 diabetes (
18372903
30054458
30297969
)
Interacting Genes
21 interacting genes:
AKT1
ARNT
ATM
AURKA
BAG4
BCAR3
BCL6
CDKN2C
ERCC6
FGFR2
FGFR4
FOXK2
FZR1
GRB2
IGF1R
KDM1A
NACC2
NOTCH2
PARP1
TGFB1
TSG101
31 interacting genes:
ANKRD28
CCR2
CNTN1
CRKL
CST6
DLL1
DTX1
DTX3
EGFL7
EPSTI1
GSK3B
IL13RA2
IL24
ITIH5
JAG1
JAG2
KLK5
LFNG
LRATD2
MAML1
MAML2
MAML3
MFNG
MTA3
MYOC
PSEN1
PSEN2
PSMC3IP
RBPJ
SMAD1
ST14
Entrez ID
57504
4853
HPRD ID
12359
02606
Ensembl ID
ENSG00000057935
ENSG00000134250
Uniprot IDs
F6RRE2
Q9BTC8
Q04721
Q6IQ50
Q9UFD5
PDB IDs
2OO4
5MWB
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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