MIF4GD and EXOSC6

Data Source:
HPRD (two hybrid)

		MIF4GD	EXOSC6
Description		MIF4G domain containing	exosome component 6
Image		No pdb structure
GO Annotations	Cellular Component	Nucleolus Golgi Apparatus Cytosol	Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Nucleoplasm Nucleolus Cytosol
	Molecular Function	RNA Binding Protein Binding Protein C-terminus Binding Translation Activator Activity Identical Protein Binding	RNA Binding Exoribonuclease Activity
	Biological Process	Regulation Of Translational Initiation Positive Regulation Of Translation	RRNA Processing RRNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5' U4 SnRNA 3'-end Processing Regulation Of MRNA Stability Exonucleolytic Catabolism Of Deadenylated MRNA DNA Deamination Isotype Switching Positive Regulation Of Isotype Switching Nuclear MRNA Surveillance Polyadenylation-dependent SnoRNA 3'-end Processing RNA Phosphodiester Bond Hydrolysis, Exonucleolytic
Pathways			ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
GWAS			Brain morphology (MOSTest) ( 32665545) Malaria ( 31844061)
Interacting Genes		23 interacting genes: AQP1 ATPAF2 CFAP206 CHCHD2 CRYBA4 CTIF DDIAS DDX19A DDX19B EIF3G ENKD1 EXOSC6 FAM110A HDAC4 HGS HINFP MKRN3 NTAQ1 PDE4DIP PPARG SMARCB1 SVIL UBQLN4	37 interacting genes: C1QBP CHPF DCP1B DIS3 DNAJC30 EIF3I ESRRA EXOSC1 EXOSC10 EXOSC2 EXOSC4 EXOSC5 EXOSC7 EXOSC8 EXOSC9 GSE1 HBS1L LSM1 LSM7 LSM8 MAN2C1 MIF4GD MOCS3 MPHOSPH6 MRPL4 MRPS18B MTREX NDUFA13 NUDT21 PALS2 PSMB1 RAB3GAP2 SRSF3 TUFM UPF2 XRN1 ZFP36
Entrez ID		57409	118460
HPRD ID		10629	12107
Ensembl ID		ENSG00000125457	ENSG00000223496
Uniprot IDs		A0A0S2Z5K9 A0A0S2Z5S7 A0A0S2Z5T5 A0A3B3IU65 A9UHW6	Q5RKV6
PDB IDs			2NN6 6D6Q 6D6R 6H25
Enriched GO Terms of Interacting Partners?
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