VANGL2 and MAGI3

Data Source:
HPRD (in vitro, in vivo)

		VANGL2	MAGI3
Description		VANGL planar cell polarity protein 2	membrane associated guanylate kinase, WW and PDZ domain containing 3
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Cell-cell Junction Integral Component Of Membrane Apical Plasma Membrane Lateral Plasma Membrane	Nucleus Cytoplasm Plasma Membrane Cell-cell Junction Bicellular Tight Junction Membrane Cell Junction
	Molecular Function	Protein Binding	Guanylate Kinase Activity Protein Binding ATP Binding Molecular Adaptor Activity
	Biological Process	Establishment Of Planar Polarity Neural Tube Closure Heart Looping Cell Migration Involved In Kidney Development Apical Protein Localization Wnt Signaling Pathway, Planar Cell Polarity Pathway Non-motile Cilium Assembly	Apoptotic Process Signal Transduction Viral Process Intracellular Signal Transduction GMP Metabolic Process Regulation Of JNK Cascade GDP Metabolic Process
Pathways		PCP/CE pathway Asymmetric localization of PCP proteins
Drugs
Diseases
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cognitive performance ( 19734545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Left-handedness ( 32989287) Multiple sclerosis ( 31604244 24076602) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Systemic lupus erythematosus ( 28714469)	Alopecia areata ( 25608926) Autoimmune thyroid disease ( 32581359) Bacteremia ( 27236921) Bulimia nervosa ( 23568457) Cerebrospinal fluid clusterin levels ( 26545630) Cognitive decline rate in late mild cognitive impairment ( 26252872) Crohn's disease ( 28067908) Gut microbiota (bacterial taxa) ( 27694959) Leukocyte telomere length ( 32109421) Neuroblastoma or malignant cutaneous melanoma ( 31605138) Obesity-related traits ( 23251661) Parental lifespan ( 30642433) Type 1 diabetes and autoimmune thyroid diseases ( 25936594)
Interacting Genes		5 interacting genes: AP1M1 ARFRP1 DVL1 MAGI3 SQSTM1	16 interacting genes: ADGRB1 ADRB1 CRHR1 DSCAML1 FZD4 FZD7 GRIN2B LATS1 NRCAM PLXNB3 PTEN PTPRB RPS6KA1 TGFA TNK2 VANGL2
Entrez ID		57216	260425
HPRD ID		02758	11290
Ensembl ID		ENSG00000162738	ENSG00000081026
Uniprot IDs		A8K4L6 Q9ULK5	Q5TCQ9
PDB IDs			3SOE
Enriched GO Terms of Interacting Partners?
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