GOPC and FZD5

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		GOPC	FZD5
Description		golgi associated PDZ and coiled-coil motif containing	frizzled class receptor 5
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GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Lysosomal Membrane Golgi Apparatus Plasma Membrane Postsynaptic Density Membrane Trans-Golgi Network Transport Vesicle Dendrite Golgi-associated Vesicle Membrane Protein-containing Complex	Golgi Membrane Plasma Membrane Integral Component Of Plasma Membrane Bicellular Tight Junction Cell Surface Integral Component Of Membrane Axon Dendrite Clathrin-coated Endocytic Vesicle Membrane Early Endosome Membrane Perikaryon Synapse Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Identical Protein Binding Ion Channel Binding	Amyloid-beta Binding G Protein-coupled Receptor Activity Protein Binding Lipid Binding Wnt-protein Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Wnt-activated Receptor Activity Protein-containing Complex Binding
	Biological Process	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Golgi To Plasma Membrane Transport Negative Regulation Of Anion Channel Activity Protein Transport Cytoplasmic Sequestering Of CFTR Protein Apical Protein Localization Negative Regulation Of Protein Localization To Cell Surface	Embryonic Axis Specification Angiogenesis Positive Regulation Of T Cell Cytokine Production G Protein-coupled Receptor Signaling Pathway Wnt Signaling Pathway, Calcium Modulating Pathway Synapse Assembly Negative Regulation Of Cell Population Proliferation Anterior/posterior Axis Specification, Embryo Neuron Differentiation Post-embryonic Camera-type Eye Development Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Tumor Necrosis Factor Production T Cell Differentiation In Thymus Non-canonical Wnt Signaling Pathway Positive Regulation Of JUN Kinase Activity Positive Regulation Of Transcription By RNA Polymerase II Cell Maturation Embryonic Camera-type Eye Morphogenesis Spemann Organizer Formation Canonical Wnt Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Apoptotic Process Involved In Morphogenesis Branching Involved In Labyrinthine Layer Morphogenesis Syncytiotrophoblast Cell Differentiation Involved In Labyrinthine Layer Development Labyrinthine Layer Blood Vessel Development Chorionic Trophoblast Cell Differentiation Cellular Response To Molecule Of Bacterial Origin Regulation Of Chorionic Trophoblast Cell Proliferation Regulation Of Autophagy Of Mitochondrion Positive Regulation Of Protein Targeting To Mitochondrion Beta-catenin Destruction Complex Disassembly Regulation Of Bicellular Tight Junction Assembly
Pathways		RHO GTPases regulate CFTR trafficking	Class B/2 (Secretin family receptors) Ca2+ pathway Ca2+ pathway Asymmetric localization of PCP proteins Disassembly of the destruction complex and recruitment of AXIN to the membrane Regulation of FZD by ubiquitination WNT5A-dependent internalization of FZD2, FZD5 and ROR2 Signaling by RNF43 mutants
Drugs
Diseases
GWAS		Atrial fibrillation ( 29892015) Colorectal cancer ( 23266556) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Facial emotion recognition (fearful faces) ( 28608620) Night sleep phenotypes ( 27126917)	Hematocrit ( 32888494) Hemoglobin ( 32888494)
Interacting Genes		70 interacting genes: ABCA1 ADRB1 AKIRIN1 ASIC3 ATG9A BATF BECN1 C17orf67 CCDC102B CCDC198 CD300C CDKN2C CERCAM CFTR CLCN3 CRHR1 CSPG5 DLEU1 DPYD FAM90A1 FAM9B FOSL2 FZD5 FZD8 GEM GOLGA3 GRID1 GRID2 HCK HNRNPLL IGHG3 JUN KPNA1 LCLAT1 MORN4 MRPL1 MYLK MYOCD NOTCH1 NUP62 OSBP2 PARK7 PID1 PPP1R18 PWWP3A RALGAPB RELA RHOQ RNF183 RNF220 RPL13AP17 RPS6KA1 RTKN SEMA4G SLC25A18 SNX31 SPATA8 SSTR5 STARD3 STX6 TGFBR2 VIM VTN ZBTB49 ZDHHC1 ZNF564 ZNF581 ZNF587 ZNF835 ZSCAN1	13 interacting genes: ABI3BP GOPC GSK3B LRP6 LZTFL1 RGS2 ROR2 RPS6KA6 SLC22A2 SLC35B1 UBTD1 WNT5A WNT7A
Entrez ID		57120	7855
HPRD ID		06024	03427
Ensembl ID		ENSG00000047932	ENSG00000163251
Uniprot IDs		Q9HD26	Q13467
PDB IDs		2DC2 2LOB 4E34 4E35 4JOE 4JOF 4JOG 4JOH 4JOJ 4JOK 4JOP 4JOR 4K6Y 4K72 4K75 4K76 4K78 4NMO 4NMP 4NMQ 4NMR 4NMS 4NMT 4NMV 4Q6H 4Q6S 5IC3 5K4F 6OV7 6XNJ	5URY 5URZ 6O39 6WW2
Enriched GO Terms of Interacting Partners?
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