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AGTRAP and FGA
Data Source:
BioGRID
(two hybrid)
AGTRAP
FGA
Description
angiotensin II receptor associated protein
fibrinogen alpha chain
Image
No pdb structure
GO Annotations
Cellular Component
Golgi Membrane
Endoplasmic Reticulum Membrane
Golgi Apparatus
Plasma Membrane
Cell Cortex
Integral Component Of Membrane
Cytoplasmic Vesicle Membrane
Intracellular Membrane-bounded Organelle
Extracellular Region
Fibrinogen Complex
Extracellular Space
Endoplasmic Reticulum Lumen
Plasma Membrane
Cell Cortex
External Side Of Plasma Membrane
Cell Surface
Platelet Alpha Granule
Platelet Alpha Granule Lumen
Synapse
Collagen-containing Extracellular Matrix
Extracellular Exosome
Blood Microparticle
Extracellular Vesicle
Molecular Function
Angiotensin Type II Receptor Activity
Protein Binding
Signaling Receptor Binding
Structural Molecule Activity
Extracellular Matrix Structural Constituent
Protein Binding
Metal Ion Binding
Cell Adhesion Molecule Binding
Biological Process
Response To Hypoxia
Regulation Of Blood Pressure
Angiotensin-activated Signaling Pathway
Toll-like Receptor Signaling Pathway
Adaptive Immune Response
Platelet Degranulation
Cell-matrix Adhesion
Blood Coagulation
Extracellular Matrix Organization
Plasminogen Activation
Positive Regulation Of Heterotypic Cell-cell Adhesion
Cellular Protein-containing Complex Assembly
Fibrinolysis
Induction Of Bacterial Agglutination
Post-translational Protein Modification
Cellular Protein Metabolic Process
Innate Immune Response
Positive Regulation Of Vasoconstriction
Positive Regulation Of Exocytosis
Positive Regulation Of Protein Secretion
Protein Polymerization
Response To Calcium Ion
Protein-containing Complex Assembly
Positive Regulation Of ERK1 And ERK2 Cascade
Platelet Aggregation
Blood Coagulation, Common Pathway
Blood Coagulation, Fibrin Clot Formation
Positive Regulation Of Peptide Hormone Secretion
Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Negative Regulation Of Endothelial Cell Apoptotic Process
Pathways
Signaling by BRAF and RAF fusions
Platelet degranulation
Common Pathway of Fibrin Clot Formation
Integrin cell surface interactions
Integrin signaling
GRB2:SOS provides linkage to MAPK signaling for Integrins
p130Cas linkage to MAPK signaling for integrins
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
MAP2K and MAPK activation
Regulation of TLR by endogenous ligand
Signaling by moderate kinase activity BRAF mutants
Signaling by high-kinase activity BRAF mutants
Signaling by BRAF and RAF fusions
Paradoxical activation of RAF signaling by kinase inactive BRAF
Post-translational protein phosphorylation
Signaling downstream of RAS mutants
Signaling by RAF1 mutants
Amyloid fiber formation
Drugs
Alteplase
Reteplase
Anistreplase
Tenecteplase
Sucralfate
Zinc
Alfimeprase
Ancrod
EP-2104R
Lanoteplase
Thrombin
Prothrombin
Human thrombin
Thrombin alfa
Anti-inhibitor coagulant complex
Zinc acetate
Zinc chloride
Zinc sulfate, unspecified form
Diseases
Afibrinogenemia; Dysfibrinogenemia
Inherited thrombophilia
Familial amyloidosis
GWAS
Arterial stiffness (brachial-femoral pulse wave velocity) (
32790701
)
Basophil percentage of white cells (
32888494
)
Systolic blood pressure (
19430483
)
D-dimer levels (
21502573
)
Fibrinogen (
20031577
21757653
)
Ischemic stroke (
29531354
)
Stroke (
29531354
)
Venous thromboembolism (
21980494
)
Interacting Genes
138 interacting genes:
ACSF2
AGTR1
AGTR2
ALDH18A1
ANKS6
AP3M1
APOA4
AQP6
ARAF
ARFIP2
ARHGAP1
ATP5F1E
BCL2L13
BPIFA2
CAPNS1
CCDC70
CD160
CD79A
CELA3A
CIAO2A
COQ8A
CPLX1
CPLX4
CRCT1
CYB5R3
CYBC1
DDA1
DDX55
DGCR6
DIABLO
DNAJC1
ECPAS
ERGIC3
ETFRF1
FAM114A1
FAM209A
FARS2
FASTKD3
FATE1
FFAR2
FGA
FHIP1B
FNDC9
GABARAPL2
GAD1
GAD2
GDNF
GPR152
GPX8
GTF2H1
GTF3C1
H4C7
HARS2
HIBADH
HMGB1
HSBP1L1
HSCB
HSD17B13
HSFX1
HSFX2
HSPA4
IL7R
ISCU
KCNK5
KIR2DL3
KIR3DL3
LMNA
LMO2
LNX1
LRRC4C
LRRC59
MCEE
MGST3
MIEF1
MIEF2
MMD
MRM1
MRPL11
MRRF
MTERF3
MUTYH
MYG1
NDRG4
NDUFAF3
NFU1
NFYB
NKG7
PBX3
PCTP
PCYT1A
PDHX
PIMREG
PITPNC1
PNPO
POLDIP2
PPIF
PRPF18
PTPN9
RAB30
RACK1
RBFA
RETREG3
RMDN2
S100B
SCAND1
SENP2
SH3GLB1
SLC18A1
SLC7A14
SMG9
SNX1
SPG21
SSX3
SSX5
STAG3L1
STAR
STARD4
STMN4
STX1A
SUCLA2
SYT16
TBRG4
TCEA2
TCEANC2
TFAM
THAP4
TMEM139
TMEM14B
TMEM31
TMPPE
TPD52L3
TTPA
TUBA1B
TXN2
UBE2I
YARS2
ZFYVE21
ZNF391
27 interacting genes:
AGTRAP
APP
CDH5
EXOC5
F13A1
F2
FGB
FGG
HRG
ITGA2B
ITGB3
MEOX2
NID1
PLAT
PRRC2A
SERPINA5
SERPINF2
SH3BP1
STX1B
STX2
SYCE1L
TFIP11
THBS1
TMEM43
TPM1
TPM3
UBC
Entrez ID
57085
2243
HPRD ID
16379
00619
Ensembl ID
ENSG00000177674
ENSG00000171560
Uniprot IDs
Q6RW13
P02671
PDB IDs
1BBR
1DM4
1FPH
1FZA
1FZB
1FZC
1FZD
1FZE
1FZF
1FZG
1LT9
1LTJ
1N86
1N8E
1RE3
1RE4
1RF0
1RF1
1YCP
2A45
2FFD
2H43
2HLO
2HOD
2HPC
2OYH
2OYI
2Q9I
2XNX
2XNY
2Z4E
3AT0
3BVH
3E1I
3GHG
3H32
3HUS
4F27
5CFA
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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