CDC42SE2 and NEU1

Data Source:
HPRD (in vivo)

		CDC42SE2	NEU1
Description		CDC42 small effector 2	neuraminidase 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Phagocytic Cup Cytoplasm Cytoskeleton Plasma Membrane Cell Projection	Extracellular Region Cytoplasm Lysosome Lysosomal Membrane Plasma Membrane Membrane Cell Junction Specific Granule Lumen Lysosomal Lumen Intracellular Membrane-bounded Organelle Extracellular Exosome
	Molecular Function	Protein Binding Signaling Adaptor Activity	Exo-alpha-sialidase Activity Protein Binding Alpha-sialidase Activity Exo-alpha-(2->3)-sialidase Activity Exo-alpha-(2->6)-sialidase Activity Exo-alpha-(2->8)-sialidase Activity
	Biological Process	Phagocytosis Regulation Of Cell Shape Regulation Of Signal Transduction Regulation Of Rho Protein Signal Transduction	Glycosphingolipid Metabolic Process Ganglioside Catabolic Process Oligosaccharide Catabolic Process Neutrophil Degranulation
Pathways			Glycosphingolipid metabolism Sialic acid metabolism Defective NEU1 causes sialidosis Neutrophil degranulation
Drugs			Oseltamivir
Diseases			Sialidosis; Mucolipidosis I Galactosialidosis Progressive myoclonic epilepsy (PME), including: Lafora disease (LBD); Unverricht-Lundborg disease (ULD); Neuronal ceroid lipofuscinoses (NCL); Type I sialidosis; Action myoclonus-renal failure syndrome (AMRF); Type III Gaucher disease (GD)
GWAS		Alzheimer's disease in APOE e4- carriers ( 25778476) Apolipoprotein A1 levels ( 32203549) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Diisocyanate-induced asthma ( 25918132) HDL cholesterol levels ( 32203549) Inflammatory bowel disease ( 28067908) Itch intensity from mosquito bite ( 28199695) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Lymphocyte counts ( 32888494) Monocyte count ( 32888494) Mosquito bite size ( 28199695) Perceived unattractiveness to mosquitoes ( 28199695) Subcortical volume (MOSTest) ( 32665545) Triglyceride levels ( 32203549) Ulcerative colitis ( 28067908)	Asthma ( 31619474) Asthma (childhood onset) ( 31619474) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Basal cell carcinoma ( 27539887) Blood protein levels ( 28240269) Estimated glomerular filtration rate ( 31152163) Inflammatory bowel disease ( 28067908) Neutrophil percentage of white cells ( 32888494) Platelet distribution width ( 32888494) Small cell lung carcinoma ( 28604730) Squamous cell lung carcinoma ( 28604730) Ulcerative colitis ( 28067908)
Interacting Genes		1 interacting genes: RAC1	29 interacting genes: AQP6 CCR9 CD79A CERS3 CERS4 CREB3 CREB3L1 CTSA EBP EEF1A1 ERGIC3 ERRFI1 GLB1 GOLM1 GPR152 GPX8 HSD17B11 JUNB KCNA2 KCNA4 LIG4 LMNA MGST3 MUC1 SLC10A1 SLC10A6 SLC18A1 SLC39A9 TMEM14B
Entrez ID		56990	4758
HPRD ID		16695	09751
Ensembl ID		ENSG00000158985	ENSG00000204386
Uniprot IDs		Q9NRR3	Q5JQI0 Q99519
PDB IDs
Enriched GO Terms of Interacting Partners?
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