FEM1C and DCP2

Data Source:
HPRD (in vitro)

		FEM1C	DCP2
Description		fem-1 homolog C	decapping mRNA 2
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleoplasm Cytosol	P-body Nucleoplasm Cytoplasm Cytosol RISC Complex Cell Junction Cytoplasmic Ribonucleoprotein Granule
	Molecular Function	Protein Binding	5'-3' Exoribonuclease Activity Protein Binding Exoribonuclease Activity, Producing 5'-phosphomonoesters Manganese Ion Binding M7G(5')pppN Diphosphatase Activity Telomerase RNA Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Post-translational Protein Modification	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA MRNA Catabolic Process Negative Regulation Of Telomere Maintenance Via Telomerase Regulation Of MRNA Stability Exonucleolytic Catabolism Of Deadenylated MRNA Histone MRNA Catabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Regulation Of Telomerase RNA Localization To Cajal Body
Pathways		Neddylation	ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 5' to 3' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA
Drugs
Diseases
GWAS		Conotruncal heart defects (inherited effects) ( 28468790) Response to antidepressants (symptom improvement) ( 29160301)	Worry/vulnerability (special factor of neuroticism) ( 30867560)
Interacting Genes		7 interacting genes: BCL2L11 CEP63 LZTS2 MALT1 MCM8 PNMA1 RPGRIP1	12 interacting genes: AGO1 AGO2 DCP1A DCP1B MIR15B MTOR NAGK POLA2 PSMB1 TRIM21 UPF1 UPF2
Entrez ID		56929	167227
HPRD ID		16384	13125
Ensembl ID		ENSG00000145780	ENSG00000172795
Uniprot IDs		Q96JP0	Q8IU60
PDB IDs		6LBG 6LBN 6LDP 6LE6 6LEN 6LEY 6LF0 6XKC 7JYA	5MP0 5QOH 5QOI 5QOJ 5QOK 5QOL 5QOM 5QON 5QOO 5QOP 5QOQ 5QOR 5QOS 5QOT 5QOU 5QOV 5QOW 5QOX 5QOY 5QOZ 5QP0 5QP1 5QP2 5QP3 5QP4 5QP5 5QP6 5QP7 5QP8 5QP9 5QPA 5QPB 5QPC
Enriched GO Terms of Interacting Partners?
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