FEM1C and MALT1

Data Source:
BioGRID (two hybrid)

		FEM1C	MALT1
Description		fem-1 homolog C	MALT1 paracaspase
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleoplasm Cytosol	Fibrillar Center Polkadots Nucleus Cytoplasm Cytosol CBM Complex Protein-containing Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding	Protease Binding Cysteine-type Endopeptidase Activity Ubiquitin-protein Transferase Activity Protein Binding Peptidase Activity Kinase Activator Activity Identical Protein Binding Protein Self-association
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Post-translational Protein Modification	B-1 B Cell Differentiation Stimulatory C-type Lectin Receptor Signaling Pathway Positive Regulation Of T Cell Cytokine Production Proteolysis Defense Response Activation Of NF-kappaB-inducing Kinase Activity Response To Fungus Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-2 Production Fc-epsilon Receptor Signaling Pathway T Cell Proliferation B Cell Activation Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Innate Immune Response T Cell Receptor Signaling Pathway Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Nuclear Export Positive Regulation Of T-helper 17 Cell Differentiation
Pathways		Neddylation	Activation of NF-kappaB in B cells Activation of NF-kappaB in B cells Downstream TCR signaling FCERI mediated NF-kB activation FCERI mediated NF-kB activation CLEC7A (Dectin-1) signaling CLEC7A/inflammasome pathway
Drugs
Diseases
GWAS		Conotruncal heart defects (inherited effects) ( 28468790) Response to antidepressants (symptom improvement) ( 29160301)	Metabolite levels ( 23823483) Multiple sclerosis ( 31604244 21833088)
Interacting Genes		7 interacting genes: BCL2L11 CEP63 LZTS2 MALT1 MCM8 PNMA1 RPGRIP1	16 interacting genes: BCL10 CARM1 FEM1A FEM1C KDM1A PRMT6 RBCK1 RELB SQSTM1 SUV39H1 TRAF2 TRAF6 UBC UBE2N UBE2V2 USP2
Entrez ID		56929	10892
HPRD ID		16384	06892
Ensembl ID		ENSG00000145780	ENSG00000172175
Uniprot IDs		Q96JP0	A8K5S1 Q9UDY8
PDB IDs		6LBG 6LBN 6LDP 6LE6 6LEN 6LEY 6LF0 6XKC 7JYA	2G7R 3BFO 3K0W 3UO8 3UOA 3V4O 3V55 4I1P 4I1R 6F7I 6GK2 6H4A 6YN8 6YN9
Enriched GO Terms of Interacting Partners?
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