PSMA3 and TCF7L2

Data Source:
BioGRID (two hybrid)

		PSMA3	TCF7L2
Description		proteasome 20S subunit alpha 3	transcription factor 7 like 2
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GO Annotations	Cellular Component	Proteasome Complex Nucleus Nucleoplasm Cytoplasm Cytosol Proteasome Core Complex Proteasome Core Complex, Alpha-subunit Complex Synapse Extracellular Exosome	Chromatin Nucleus Nucleoplasm PML Body Protein-DNA Complex Beta-catenin-TCF7L2 Complex Catenin-TCF7L2 Complex Beta-catenin-TCF Complex
	Molecular Function	Endopeptidase Activity Protein Binding Ubiquitin Protein Ligase Binding	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Repressing Transcription Factor Binding DNA-binding Transcription Factor Activity Protein Binding Beta-catenin Binding Transcription Factor Binding Protein Kinase Binding Nuclear Hormone Receptor Binding Sequence-specific DNA Binding Gamma-catenin Binding Armadillo Repeat Domain Binding
	Biological Process	MAPK Cascade Protein Polyubiquitination Stimulatory C-type Lectin Receptor Signaling Pathway Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Regulation Of Cellular Amino Acid Metabolic Process Proteasomal Ubiquitin-independent Protein Catabolic Process Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Viral Process Protein Deubiquitination Anaphase-promoting Complex-dependent Catabolic Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Tumor Necrosis Factor-mediated Signaling Pathway NIK/NF-kappaB Signaling Fc-epsilon Receptor Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of MRNA Stability Post-translational Protein Modification T Cell Receptor Signaling Pathway Regulation Of Endopeptidase Activity Transmembrane Transport Wnt Signaling Pathway, Planar Cell Polarity Pathway Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Interleukin-1-mediated Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Hematopoietic Stem Cell Differentiation	Negative Regulation Of Transcription By RNA Polymerase II Blood Vessel Development Regulation Of Transcription By RNA Polymerase II Cell Cycle Arrest Wnt Signaling Pathway, Calcium Modulating Pathway Response To Glucose Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Pancreas Development Positive Regulation Of Insulin Secretion Positive Regulation Of Protein Binding Regulation Of Hormone Metabolic Process Glucose Homeostasis Negative Regulation Of DNA-binding Transcription Factor Activity Maintenance Of DNA Repeat Elements Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition Fat Cell Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Protein Export From Nucleus Myoblast Fate Commitment Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Protein Kinase B Signaling Canonical Wnt Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Beta-catenin-TCF Complex Assembly Negative Regulation Of Type B Pancreatic Cell Apoptotic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Activation of NF-kappaB in B cells Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha ER-Phagosome pathway Cross-presentation of soluble exogenous antigens (endosomes) Autodegradation of Cdh1 by Cdh1:APC/C SCF-beta-TrCP mediated degradation of Emi1 APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Vpu mediated degradation of CD4 Vif-mediated degradation of APOBEC3G SCF(Skp2)-mediated degradation of p27/p21 Degradation of beta-catenin by the destruction complex Downstream TCR signaling Regulation of activated PAK-2p34 by proteasome mediated degradation Separation of Sister Chromatids FCERI mediated NF-kB activation Autodegradation of the E3 ubiquitin ligase COP1 Regulation of ornithine decarboxylase (ODC) ABC-family proteins mediated transport AUF1 (hnRNP D0) binds and destabilizes mRNA Asymmetric localization of PCP proteins Degradation of AXIN Degradation of DVL Hedgehog ligand biogenesis Hh mutants are degraded by ERAD Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Hedgehog 'on' state Regulation of RAS by GAPs TNFR2 non-canonical NF-kB pathway NIK-->noncanonical NF-kB signaling Defective CFTR causes cystic fibrosis MAPK6/MAPK4 signaling UCH proteinases Ub-specific processing proteases CDT1 association with the CDC6:ORC:origin complex Orc1 removal from chromatin CDK-mediated phosphorylation and removal of Cdc6 G2/M Checkpoints Ubiquitin Mediated Degradation of Phosphorylated Cdc25A Ubiquitin-dependent degradation of Cyclin D The role of GTSE1 in G2/M progression after G2 checkpoint FBXL7 down-regulates AURKA during mitotic entry and in early mitosis RUNX1 regulates transcription of genes involved in differentiation of HSCs Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity Regulation of RUNX3 expression and activity Regulation of PTEN stability and activity Neddylation Regulation of expression of SLITs and ROBOs Interleukin-1 signaling Negative regulation of NOTCH4 signaling Antigen processing: Ubiquitination & Proteasome degradation	Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex Deactivation of the beta-catenin transactivating complex Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Ca2+ pathway Binding of TCF/LEF:CTNNB1 to target gene promoters Repression of WNT target genes Repression of WNT target genes Signaling by TCF7L2 mutants Transcriptional Regulation by VENTX RUNX3 regulates WNT signaling
Drugs		(3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE Phenethyl Isothiocyanate
Diseases			Type II diabetes mellitus
GWAS		Brain morphology (MOSTest) ( 32665545) Mean corpuscular hemoglobin ( 27863252) Mean corpuscular volume ( 27863252) Red blood cell count ( 32888494)	Adult body size ( 32376654) Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Bipolar disorder (body mass index interaction) ( 24322204) Blood glucose levels ( 29615537 31928498) BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) Body mass index ( 29381148 26426971 31453325 28892062 25673413 28448500) Body mass index (age>50) ( 26426971) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index in physically active individuals ( 28448500) Body mass index variance ( 31453325) Body mass index x sex x age interaction (4df test) ( 26426971) Brain morphology (MOSTest) ( 32665545) Breast cancer ( 23535729 27117709) Breast Cancer in BRCA1 mutation carriers ( 23544013) Circulating leptin levels or type 2 diabetes ( 32341051) Clinical laboratory measurements ( 27897004) Cognitive decline (age-related) ( 28078323) Colorectal cancer ( 30529582 24836286 29471430) Colorectal cancer or advanced adenoma ( 30510241) Coronary artery disease ( 29212778) Fasting blood glucose ( 25631608 20081858 22581228) Fasting blood glucose (BMI interaction) ( 22581228) Fasting blood insulin ( 22581228) Fasting blood insulin (BMI interaction) ( 22581228) Glucosuria ( 30476138) Glucosuria (mild) ( 30476138) Glucosuria (moderate to severe) ( 30476138) Glycated hemoglobin levels ( 20849430 28898252) Glycemic traits (pleiotropy) ( 31021400) Granulocyte percentage of myeloid white cells ( 27863252) Gut microbiota relative abundance (Ruminococcus belonging to family Lachnospiraceae) ( 33208821) Heel bone mineral density ( 30598549 28869591) Hemoglobin ( 32888494) Hemoglobin A1c levels ( 29403010) High light scatter reticulocyte count ( 32888494) High myopia ( 31816047) Hip circumference ( 25673412) Insulin-related traits (multivariate analysis) ( 32002517) Intraocular pressure ( 29617998 29785010) Ischemic stroke ( 26732560) Medication use (drugs used in diabetes) ( 31015401) Medication use (HMG CoA reductase inhibitors) ( 31015401) Metabolic syndrome ( 20694148) Metabolite levels ( 23823483) Monocyte percentage of white cells ( 32888494 27863252) Myopia ( 27182965) Offspring birth weight ( 31043758) Peak insulin response ( 28490609) Peripheral artery disease ( 31285632) Proinsulin levels ( 21873549) Prostate cancer ( 29892016) Pulse pressure ( 27841878 30578418) Refractive error ( 32231278) Retinopathy x type 2 diabetes interaction ( 32541925) Schizophrenia vs type 2 diabetes ( 30470734) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Systolic blood pressure ( 27841878 30578418) Two-hour glucose challenge ( 20081857) Type 2 diabetes ( 27189021 17668382 22885922 18372903 24509480 17293876 30054458 30470734 22693455 26961502 31324766 29358691 25102180 30297969 19734900 28254843 25483131 17554300 26818947 31049640 23945395 31118516 23300278 32499647 20581827 19401414 24390345 17463246 30718926 17463248 17463249 22101970 21347282 28869590 17460697 19056611 23209189) Urate levels ( 31578528) Waist circumference ( 25673412) Waist-to-hip ratio adjusted for body mass index ( 28430825)
Interacting Genes		113 interacting genes: ADGRL1 APLN ATN1 ATP6V0C AURKB BTN2A2 BTRC C1orf105 C9orf106 CCDC69 CCL28 CDK6 CDKN1A CRB3 CRYAB CSNK2A1 CST2 CTBP1-DT CYBA DDX5 DGLUCY DMC1 DMRT3 DVL1 EGR1 FAM171A2 FAM218A FAM83A FBXL18 FRAT1 GATA2 GATA3 GFI1B GORASP2 HHEX HSPB1 IKBKG IQCE KIF1A KIRREL2 KIRREL3-AS3 KRAS KRTAP19-5 KRTAP26-1 KRTAP8-1 LASP1 LBP LETM1 LINC00908 MDM2 MIA2 NEU4 NOL4L-DT NPBWR2 NPPB NUMBL OSR2 PATL1 PCOTH PLK1 PML POMP PRELID3A PRNP PRR13 PRR3 PRRC2A PSMA1 PSMA2 PSMA4 PSMA6 PSMA7 PSMB10 PSMB5 PTPN23 PWWP2B PWWP3A RAB3IL1 RAD54L2 RAMAC RBFOX2 RBM42 RERE RFT1 RTP5 RUSC1-AS1 SERF2 SF1 SH3KBP1 SLAIN1 SLC22A23 SNRPB SNRPC SNRPF SPATA8 SRPK2 STUB1 STX11 STX1A STX4 STX6 TBC1D16 TBX6 TCF7L2 TINCR TRIB3 URB1-AS1 VPS37C XRN2 YPEL3 ZNF366 ZNF385C ZNF688	47 interacting genes: AR BPIFA1 C19orf54 CCNG2 CNFN CRX CSNK2A1 CSNK2A2 CTNNB1 CTNNBIP1 CYSRT1 DAXX DAZAP2 EP300 FAM168B FBLN1 HIC1 INTS11 JUP KCNE4 KMT5A KRTAP19-5 KRTAP19-7 KRTAP21-2 KRTAP6-1 KRTAP6-2 KRTAP6-3 KRTAP7-1 MEN1 MSX2 PRKAB2 PRR20A PRR20B PRR20C PRR20D PRR20E PSEN1 PSMA3 RBPMS RNF138 SMUG1 TLE3 TLE5 TRAF1 TSC1 UFSP1 ZNF34
Entrez ID		5684	6934
HPRD ID		01463	03751
Ensembl ID		ENSG00000100567	ENSG00000148737
Uniprot IDs		A0A140VK43 P25788	A0A0A0MTL7 C6ZRJ7 C6ZRK1 C6ZRK2 C6ZRK5 Q5VVR7 Q6FHW4 Q9NQB0
PDB IDs		4R3O 4R67 5A0Q 5DSV 5GJQ 5GJR 5L4G 5LE5 5LEX 5LEY 5LEZ 5LF0 5LF1 5LF3 5LF4 5LF6 5LF7 5LN3 5M32 5T0C 5T0G 5T0H 5T0I 5T0J 5VFO 5VFP 5VFQ 5VFR 5VFS 5VFT 5VFU 6AVO 6E5B 6KWY 6MSB 6MSD 6MSE 6MSG 6MSH 6MSJ 6MSK 6R70 6REY 6RGQ 6WJD 6WJN 6XMJ	1JDH 1JPW 2GL7
Enriched GO Terms of Interacting Partners?
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