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TRIM39 and UBE2N
Data Source:
BioGRID
(pull down)
TRIM39
UBE2N
Description
tripartite motif containing 39
ubiquitin conjugating enzyme E2 N
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Mitochondrion
Cytosol
Ubiquitin Ligase Complex
Fibrillar Center
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
UBC13-MMS2 Complex
Protein-containing Complex
UBC13-UEV1A Complex
Extracellular Exosome
Molecular Function
Protein Binding
Zinc Ion Binding
Identical Protein Binding
Ubiquitin Protein Ligase Activity
RNA Binding
Ubiquitin-protein Transferase Activity
Protein Binding
ATP Binding
Ubiquitin Protein Ligase Binding
Ubiquitin Binding
Ubiquitin Conjugating Enzyme Activity
Biological Process
Apoptotic Process
Mitotic G2 DNA Damage Checkpoint
Regulation Of Gene Expression
Protein Ubiquitination
Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Innate Immune Response
Protein Stabilization
Regulation Of Cell Cycle G1/S Phase Transition
Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Apoptotic Signaling Pathway
Activation Of MAPK Activity
Protein Polyubiquitination
Double-strand Break Repair Via Homologous Recombination
DNA Double-strand Break Processing
Regulation Of DNA Repair
Postreplication Repair
Double-strand Break Repair Via Nonhomologous End Joining
Ubiquitin-dependent Protein Catabolic Process
JNK Cascade
Protein Ubiquitination
Histone Ubiquitination
Positive Regulation Of Histone Modification
Regulation Of Histone Ubiquitination
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of DNA Repair
T Cell Receptor Signaling Pathway
Positive Regulation Of NF-kappaB Transcription Factor Activity
Positive Regulation Of Ubiquitin-protein Transferase Activity
Nucleotide-binding Oligomerization Domain Containing Signaling Pathway
Interleukin-1-mediated Signaling Pathway
Protein K63-linked Ubiquitination
Pathways
Antigen processing: Ubiquitination & Proteasome degradation
ISG15 antiviral mechanism
NOD1/2 Signaling Pathway
TICAM1, RIP1-mediated IKK complex recruitment
Downstream TCR signaling
FCERI mediated NF-kB activation
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
activated TAK1 mediates p38 MAPK activation
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
CLEC7A (Dectin-1) signaling
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Nonhomologous End-Joining (NHEJ)
Processing of DNA double-strand break ends
Formation of Incision Complex in GG-NER
G2/M DNA damage checkpoint
E3 ubiquitin ligases ubiquitinate target proteins
Interleukin-1 signaling
IRAK1 recruits IKK complex
IKK complex recruitment mediated by RIP1
Aggrephagy
Aggrephagy
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS
Asthma (adult onset) (
31036433
)
Asthma (childhood onset) (
31036433
)
Autism spectrum disorder or schizophrenia (
28540026
)
Blood protein levels (
28240269
)
Cutaneous lupus erythematosus (
25827949
)
Neuroticism (
29255261
)
Height (
18391951
)
Mean reticulocyte volume (
32888494
)
Interacting Genes
61 interacting genes:
APP
CACTIN
CCNC
DCUN1D1
DCX
DIP2A
EIF4A2
EPHB6
GAMT
HINFP
KDM1A
LMNA
LNX1
LXN
MED18
MNAT1
MTURN
OTUB2
OTUD6A
PDLIM5
PLCD4
POLI
PRPF3
PSMA6
PSMB1
PSMD9
RAD23A
RECK
RNF166
SMCO3
TP53
TRIM17
TRIM21
TRIM8
TTC32
UBAC1
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2E1
UBE2E2
UBE2E3
UBE2K
UBE2L3
UBE2N
UBE2V1
UBE2W
UBL5
UBTD1
UBTD2
UBXN1
UBXN6
UBXN7
USP2
USP39
USP5
WDFY3
ZKSCAN4
ZNF26
115 interacting genes:
AMFR
ARIH1
ARIH2
AURKA
BARD1
BCL10
BFAR
BIRC2
BIRC3
BIRC8
BRCA1
CADPS2
CBL
CCNB1
CHFR
CHUK
CNOT4
DTL
DTX1
DZIP3
F12
HERC2
HSP90AA1
LNX1
LRSAM1
MALT1
MARCHF5
MARCHF7
MDM2
MIB1
MIB2
MID1
MKRN3
MUL1
MYLIP
NBN
NEDD4L
NEURL1
NFX1
OTUB1
OTUB2
PEDS1
PEDS1-UBE2V1
PELI1
PELI3
PJA2
PRKN
PTTG1
RBCK1
RC3H1
RC3H2
RFFL
RFWD3
RIPK1
RNF103
RNF11
RNF111
RNF115
RNF122
RNF125
RNF126
RNF128
RNF13
RNF130
RNF135
RNF152
RNF165
RNF167
RNF181
RNF182
RNF38
RNF4
RNF43
RNF5
RNF8
SH3RF1
SH3RF2
SHPRH
SIAH1
SIAH2
SLC2A4
STUB1
TNFAIP3
TOPORS
TP53
TRAF2
TRAF6
TRIM14
TRIM17
TRIM21
TRIM23
TRIM25
TRIM27
TRIM28
TRIM32
TRIM33
TRIM39
TRIM5
TRIM50
TRIM54
TRIM63
TRIM69
TRIM72
UBA1
UBB
UBC
UBE2V1
UBE2V2
UBE3A
UHRF1
XIAP
ZNRF1
ZNRF2
ZNRF3
ZNRF4
Entrez ID
56658
7334
HPRD ID
09298
04725
Ensembl ID
ENSG00000204599
ENSG00000177889
Uniprot IDs
A0A024RCP5
A0A024RCR1
Q9HCM9
P61088
V9HW41
PDB IDs
2DID
2DIF
2ECJ
1J7D
2C2V
3HCT
3HCU
3VON
3W31
4DHI
4DHJ
4DHZ
4IP3
4NR3
4NRG
4NRI
4ONL
4ONM
4ONN
4ORH
4TKP
4WHV
5AIT
5AIU
5EYA
5H7S
5VNZ
5VO0
5YWR
6D6I
6JKY
6KFP
6KG6
6KL4
6P5B
6S53
6ULH
6UMP
6UMS
7BXG
Enriched GO Terms of Interacting Partners
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