Description |
presenilin 1 |
nitric oxide synthase 3 |
Image |
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Cellular Component |
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Molecular Function |
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Biological Process |
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Pathways |
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Drugs |
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- Arginine
- Citrulline
- Sapropterin
- Miconazole
- N,N-dimethylarginine
- L-N(omega)-Nitroarginine-2,4-L-diaminobutyric amide
- Canavanine
- 3-Bromo-7-Nitroindazole
- N-{(4S)-4-Amino-5-[(2-aminoethyl)amino]pentyl}-N'-nitroguanidine
- N-[3-(aminomethyl)benzyl]acetamidine
- 1,2,4-Triazole-Carboxamidine
- L-N(omega)-nitroarginine-(4R)-amino-L-proline amide
- S,S'-(1,4-Phenylene-Bis(1,2-Ethanediyl))Bis-Isothiourea
- 7-Nitroindazole
- S-Ethylisothiourea
- 2-Aminothiazoline
- Se-Ethyl-Isoselenourea
- 2,4-Diamino-6-Phenyl-5,6,7,8,-Tetrahydropteridine
- N1,N14-Bis((S-Methyl)Isothioureido)Tetradecane
- Cacodylic acid
- 7-Nitroindazole-2-Carboxamidine
- 6-Nitroindazole
- N(5)-[(hydroxyamino)(imino)methyl]-L-ornithine
- N(G)-Iminoethylornithine
- 5,6-Cyclic-Tetrahydropteridine
- S-Ethyl-N-Phenyl-Isothiourea
- S,S'-(1,3-Phenylene-Bis(1,2-Ethanediyl))Bis-Isothiourea
- 6S-5,6,7,8-Tetrahydrobiopterin
- S-(Dimethylarsenic)Cysteine
- L-homoarginine
- S-Isopropyl-Isothiourea
- Nitroarginine
- 5-Nitroindazole
- N-(Chlorophenyl)-N'-hydroxyguanidine
- (3S,5E)-3-propyl-3,4-dihydrothieno[2,3-f][1,4]oxazepin-5(2H)-imine
- 5-{4-[(3,5-DIFLUOROBENZYL)AMINO]PHENYL}-6-ETHYLPYRIMIDINE-2,4-DIAMINE
- ETHYL 4-[(4-METHYLPYRIDIN-2-YL)AMINO]PIPERIDINE-1-CARBOXYLATE
- N-{(3S,4S)-4-[(6-AMINO-4-METHYLPYRIDIN-2-YL)METHYL]PYRROLIDIN-3-YL}-N'-(4-CHLOROBENZYL)ETHANE-1,2-DIAMINE
- N-{(3R,4S)-4-[(6-amino-4-methylpyridin-2-yl)methyl]pyrrolidin-3-yl}-N'-(3-chlorobenzyl)ethane-1,2-diamine
- Levamlodipine
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Diseases |
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GWAS |
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- Coronary artery disease ( 29212778 30104761 26343387)
- Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975)
- Diastolic blood pressure ( 27841878 28739976 27618448)
- Diastolic blood pressure (cigarette smoking interaction) ( 29455858)
- Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962)
- Estimated glomerular filtration rate ( 31451708)
- Eyebrow thickness ( 26926045)
- Hypertension ( 27618448)
- Mean arterial pressure ( 27618448)
- Mean platelet volume ( 32888494)
- Medication use (agents acting on the renin-angiotensin system) ( 31015401)
- Medication use (beta blocking agents) ( 31015401)
- Medication use (calcium channel blockers) ( 31015401)
- Medication use (diuretics) ( 31015401)
- Medication use (HMG CoA reductase inhibitors) ( 31015401)
- Offspring birth weight ( 31043758)
- Periventricular white matter hyperintensities ( 32517579)
- Platelet distribution width ( 32888494)
- Stroke ( 30383316)
- Systolic blood pressure ( 27841878 27618448 30578418)
- Systolic blood pressure (cigarette smoking interaction) ( 29455858)
- Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962)
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Interacting Genes |
92 interacting genes:
ACTN1
AP1M2
APBA1
APH1A
APH1B
APOE
APP
BACE1
BCL2
BCL2L1
CASP1
CASP3
CASP4
CASP6
CASP7
CASP8
CDH1
CDK5
CFL1
CIB1
CTNNA1
CTNNB1
CTNND1
CTNND2
CYP2C18
CYP2C8
DLL1
DOCK3
ECSIT
EFHD1
EFNB2
ENSA
EPB41L3
ERN1
ETFA
FBXL12
FBXW7
FGF13
FLNA
FLNB
GAPDH
GCDH
GDI1
GFAP
GSK3B
HERPUD1
HMGB1
ICAM5
ITSN2
JUP
KANK2
KCNIP3
KCNIP4
MAPK9
MAPT
METTL2B
MTCH1
NCSTN
NOS3
NOTCH1
NOTCH2
NOTCH3
NOTCH4
OXCT1
PDCD4
PIK3R1
PKP4
PRAM1
PRDX2
PRKACA
PRKCZ
PSENEN
PSMA5
PSMB1
RAB11A
RAB3A
RAD23A
RHEB
RMDN3
RNF32
RYR2
SCAF11
SCN1A
SLC10A6
ST13
STAMBPL1
TCF7L2
TDP2
TUBA1B
UBQLN1
UMPS
YME1L1
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47 interacting genes:
A2M
ACTN2
ACTN4
AGTR1
AKT1
APOE
APP
BDKRB2
BDNF
CALM1
CAV1
CDC37
CEP55
EDNRB
EFEMP1
EFEMP2
ELAVL1
ELAVL3
EXOC6
EXOSC1
FIS1
GCDH
GOLGA2
H3-3A
HSP90AA1
HTRA1
IKZF3
IMMT
KANK2
MAGEA11
MAST1
MPRIP
NMT1
NOSIP
NOSTRIN
PAXIP1
PI4K2A
PPP2R5A
PSEN1
PSEN2
RNF31
RNF32
SP1
ST13
TECR
TXNDC11
UMPS
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Entrez ID |
5663 |
4846 |
HPRD ID |
00087 |
01224 |
Ensembl ID |
ENSG00000080815
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ENSG00000164867
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Uniprot IDs |
A0A024R6A3
A0A0S2Z4D2
P49768
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A0S0A6
P29474
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PDB IDs |
2KR6
4UIS
5A63
5FN2
5FN3
5FN4
5FN5
6IDF
6IYC
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1M9J
1M9K
1M9M
1M9Q
1M9R
1NIW
2LL7
2MG5
2N8J
3EAH
3NOS
4D1O
4D1P
5UO8
5UO9
5UOA
5UOB
5UOC
5VVB
5VVC
5VVD
5XOF
6AV6
6AV7
6CIE
6CIF
6NH1
6NH2
6NH3
6NH4
6NH5
6NH6
6NH7
6NH8
6NHF
6POU
6POV
6POW
6POX
6POY
6POZ
6PP0
6PP1
6PP2
6PP3
6PP4
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Enriched GO Terms of Interacting Partners? |
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Tagcloud ? |
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Tagcloud (Difference) ? |
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Tagcloud (Intersection) ? |
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