PRSS3 and TFPI

Data Source:
BioGRID (x-ray crystallography)
HPRD (in vitro)

		PRSS3	TFPI
Description		serine protease 3	tissue factor pathway inhibitor
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Tertiary Granule Lumen	Extracellular Region Extracellular Space Endoplasmic Reticulum Plasma Membrane Caveola Cell Surface Organelle Membrane Anchored Component Of Membrane
	Molecular Function	Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding	Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity
	Biological Process	Proteolysis Digestion Cobalamin Metabolic Process Antimicrobial Humoral Response Zymogen Activation Neutrophil Degranulation Endothelial Cell Migration	Blood Coagulation Blood Coagulation, Extrinsic Pathway Negative Regulation Of Endopeptidase Activity Negative Regulation Of Blood Coagulation Response To Estradiol Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-1 Cellular Response To Steroid Hormone Stimulus
Pathways		Alpha-defensins Cobalamin (Cbl, vitamin B12) transport and metabolism Neutrophil degranulation Antimicrobial peptides	Extrinsic Pathway of Fibrin Clot Formation
Drugs		4-(1,3,2-Dioxaborolan-2-Yloxy)Butan-1-Aminium 4-Hydroxybutan-1-Aminium 4-(Hydroxymethyl)Benzamidine Benzamidine Diamino-N-[3-(1,3,2-dioxaborolan-2-yloxy)propyl]methaniminium Guanidine-3-propanol [4-(1,3,2-Dioxaborolan-2-Yloxy)Methyl]Benzamidine 1,3,2-Dioxaborolan-2-Ol	Coagulation factor VIIa Recombinant Human Dalteparin Andexanet alfa
Diseases
GWAS		Bipolar disorder ( 20351715) Hand grip strength ( 29691431) Refractive error ( 32231278) Triglycerides ( 30275531)	Apolipoprotein A1 levels ( 32203549) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Diffusing capacity of carbon monoxide ( 30694715) Heart rate ( 23583979) Lung adenocarcinoma ( 28604730) Serum immune biomarker levels ( 32066700) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)
Interacting Genes		4 interacting genes: APP LINC00839 SERPINA1 TFPI	10 interacting genes: APP ELANE F10 MMP1 MMP12 MMP7 MMP8 MMP9 PRSS3 THBS1
Entrez ID		5646	7035
HPRD ID		06685	01064
Ensembl ID		ENSG00000010438	ENSG00000003436
Uniprot IDs		P35030 Q7Z5F4	P10646
PDB IDs		1H4W 2R9P 3L33 3L3T 3P92 3P95 4DG4 4U30 4U32 5C67 5JBT 5TP0 6BX8 6GFI	1ADZ 1IRH 1TFX 4BQD 4DTG 5NMV 6BX8
Enriched GO Terms of Interacting Partners?
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