PRNP and BAZ2B

Data Source:
BioGRID (pull down)

		PRNP	BAZ2B
Description		prion protein	bromodomain adjacent to zinc finger domain 2B
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Endoplasmic Reticulum Golgi Apparatus Cytosol Plasma Membrane Cell Surface Postsynaptic Density Inclusion Body Extrinsic Component Of Membrane Dendrite Anchored Component Of External Side Of Plasma Membrane Nuclear Membrane Intracellular Membrane-bounded Organelle Membrane Raft Extracellular Exosome Postsynapse	Nucleus
	Molecular Function	Amyloid-beta Binding Protease Binding Copper Ion Binding Calcium Ion Binding Protein Binding Glycosaminoglycan Binding Microtubule Binding Tubulin Binding Aspartic-type Endopeptidase Inhibitor Activity Type 5 Metabotropic Glutamate Receptor Binding Type 8 Metabotropic Glutamate Receptor Binding Signaling Receptor Activity Identical Protein Binding Protein-containing Complex Binding Cuprous Ion Binding	DNA Binding Protein Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Protein Phosphorylation Cellular Copper Ion Homeostasis Response To Oxidative Stress Cell Cycle Arrest Learning Or Memory Long-term Memory Negative Regulation Of Endopeptidase Activity Negative Regulation Of Protein Processing Protein Destabilization Negative Regulation Of Interferon-gamma Production Negative Regulation Of Interleukin-17 Production Negative Regulation Of Interleukin-2 Production Calcium-mediated Signaling Using Intracellular Calcium Source Negative Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Neuron Apoptotic Process Negative Regulation Of Activated T Cell Proliferation Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Negative Regulation Of T Cell Receptor Signaling Pathway Protein Homooligomerization Positive Regulation Of Protein Tyrosine Kinase Activity Negative Regulation Of Calcineurin-NFAT Signaling Cascade Cellular Response To Copper Ion Positive Regulation Of Protein Targeting To Membrane Modulation Of Age-related Behavioral Decline Dendritic Spine Maintenance Regulation Of Glutamate Receptor Signaling Pathway Positive Regulation Of Neuron Death Negative Regulation Of Amyloid-beta Formation Regulation Of Intracellular Calcium Activated Chloride Channel Activity Negative Regulation Of Dendritic Spine Maintenance Negative Regulation Of Amyloid Precursor Protein Catabolic Process Response To Amyloid-beta Cellular Response To Amyloid-beta Regulation Of Calcium Ion Import Across Plasma Membrane Neuron Projection Maintenance	Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II
Pathways		NCAM1 interactions Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Drugs		Tetracycline Copper
Diseases		Prion diseases; Creutzfeldt-Jacob disease (CJD); Gerstmann-Straussler disease (GSD); Gerstmann-Straussler-Scheinker disease (GSSD); Fatal familial insomnia (FFI)
GWAS		Creutzfeldt-Jakob disease ( 19081515) Creutzfeldt-Jakob disease (sporadic) ( 32949544 25918841) Creutzfeldt-Jakob disease (variant) ( 22137330) KANNO antigen negativity ( 31020675) Platelet aggregation ( 20526338) Prion diseases ( 22210626) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI (smoking interaction) ( 28443625)	Neutrophil percentage of white cells ( 32888494) Night sleep phenotypes ( 27126917) Proportion of activated microglia (inferior temporal cortex) ( 30679421) Refractive error ( 32231278) Sudden cardiac arrest ( 21738491) Tourette syndrome ( 30818990)
Interacting Genes		96 interacting genes: ABT1 ADAM23 ADAP2 ADRB2 AGO1 AIFM3 APBB1 APLP1 APLP2 APOE ARHGAP15 ATIC BAG6 BAZ2B C7orf50 CAV1 CCDC149 CCR1 CIRBP CLSTN1 CLU CNP CNTN1 CRYAB CSN3 CSNK2A1 CSNK2A2 CSNK2B CWC15 DDX47 DNM1 DOCK7 DPP6 DYRK3 ERI3 F2RL1 FAM27E3 FBLN5 FBXO45 FGF13 FHL1 FZD7 GRB2 HAX1 HSPA5 HSPD1 IER3 KIAA1191 KIFAP3 L1CAM LMNA LSAMP MAG MARK4 MMADHC MOG MTG1 NCAM1 NCAM2 NECTIN1 NHP2 NIPSNAP2 NOB1 OPCML P4HB PDE4DIP PLG PPFIBP2 PPP1R14A PSMA3 PSMB5 PTAFR PTRH1 PYM1 RBM22 RNPC3 RPL41 SCNM1 SEC31A SPARCL1 STARD5 STIP1 SURF2 TBPL1 TMEM237 TRIM15 TSC22D4 TSLP TYMSOS UTP4 WDR5 WDR61 ZFYVE28 ZKSCAN8 ZNF408 ZNF740	17 interacting genes: APIP BIVM CEP70 CTBP2 FXR2 GOLGA2 HMBOX1 HSF2BP PRNP RASGEF1B SEPTIN2 STAC3 TFIP11 TRAF2 TRIM23 ZBTB14 ZBTB8A
Entrez ID		5621	29994
HPRD ID		01453	09295
Ensembl ID		ENSG00000171867	ENSG00000123636
Uniprot IDs		F7VJQ1 P04156 Q53YK7	Q9UIF8
PDB IDs		1E1G 1E1J 1E1P 1E1S 1E1U 1E1W 1FKC 1FO7 1H0L 1HJM 1HJN 1I4M 1OEH 1OEI 1QLX 1QLZ 1QM0 1QM1 1QM2 1QM3 2IV4 2IV5 2IV6 2K1D 2KUN 2LBG 2LEJ 2LFT 2LSB 2LV1 2M8T 2OL9 2W9E 3HAF 3HAK 3HEQ 3HER 3HES 3HJ5 3HJX 3MD4 3MD5 3NHC 3NHD 3NVF 4DGI 4E1H 4E1I 4KML 4N9O 5L6R 5YJ4 5YJ5 6DU9 6LNI 6PQ5 6PQA 6SUZ 6SV2 6UUR	2E7O 3G0L 3Q2F 4CUP 4CUQ 4CUR 4CUS 4CUT 4CUU 4IR3 4IR4 4IR5 4IR6 4NR9 4NRA 4NRB 4NRC 4QC1 4QC3 4QF3 4RVR 4XUA 4XUB 5CQ3 5CQ4 5CQ5 5CQ6 5CQ7 5CQ8 5CQA 5CU8 5CUA 5CUB 5CUC 5CUD 5CUE 5CUG 5DYU 5DYX 5E73 5E74 5E9I 5E9K 5E9L 5E9M 5E9Y 5L8T 5L8U 5L96 5L97 5L98 5L99 5MGE 5MGF 5MGG 5OR9 5ORB 5PB7 5PB8 5PB9 5PBA 5PBB 5PBC 5PBD 5PBE 5PBF 5PBG 5PBH 5PBI 5PBJ 5PBK 5PBL 5PBM 5PBN 5PBO 5PBP 5PBQ 5PBR 5PBS 5PBT 5PBU 5PBV 5PBW 5PBX 5PBY 5PBZ 5PC0 5PC1 5PC2 5PC3 5PC4 5PC5 5PC6 5PC7 5PC8 5PC9 5PCA 5PCB 5PCC 5PCD 5PCE 5PCF 5PCG 5PCH 5PCI 5PCJ 5PCK 5PCL 5PCM 5PCN 5PCO 5PCP 5PCQ 5PCR 5PCS 5PCT 5PCU 5PCV 5PCW 5PCX 5PCZ 5PD0 5PD1 5PD2 5PD3 5PD4 5PD5 5PD6 5PD7 5PD8 5PD9 5PDA 5PDB 5PDC 5PDD 5PDE 5PDF 5PDG 5PDH 5PDI 5PDJ 5PDK 5PDL 5PDM 5PDN 5PDO 5PDP 5PDQ 5PDR 5PDS 5PDT 5PDU 5PDV 5PDW 5PDX 5PDY 5PDZ 5PE0 5PE1 5PE2 5PE3 5PE4 5PE5 5PE6 5PE7 5PE8 5PE9 5PEA 5PEB 5PEC 5PED 5PEE 5PEF 5PEG 5PEH 5PEI 5PEJ 5PEK 5PEL 5PEM 5PEN 5PEO 5PEQ 5PER 5PES 5PET 5PEU 5PEV 5PEW 5PEX 5PEY 5PEZ 5PF0 5PF1 5PF2 5PF3 5PF4 5PF5 5PF6 5PF7 5PF8 5PF9 5PFA 5PFB 5PFC 5PFD 5PFE 5PFF 5PFG 5PFH 5PFI 5PFJ 5PFL 5PFM 5PFN 5PFO 5PFP 5PFQ 5PFR 5PFS 5PFT 5PFU 5PFV 5PFW 5PFX 5PFY 5PFZ 5PG0 5PG1 5PG2 5PG3 5PG4 5PG5 5PG6 5PG7 5PG8 5PG9 5PGA 5PGB 5PGC 5PGD 5PGE 5PGF 5PGG 5PGH 5PGI 5PGJ 5PGK 5PGL 5PGN 5PGO 5PGP 5PGQ 5PGR 5PGS 5PGT 6FGT 6FGU 6FH6 6FH7 6FHQ 6FI1
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?