DNAJC3 and DNAJB1

Data Source:
HPRD (two hybrid, in vitro)

		DNAJC3	DNAJB1
Description		DnaJ heat shock protein family (Hsp40) member C3	DnaJ heat shock protein family (Hsp40) member B1
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GO Annotations	Cellular Component	Extracellular Region Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Lumen Smooth Endoplasmic Reticulum Cytosol Membrane Azurophil Granule Lumen Extracellular Exosome Extracellular Vesicle	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Postsynaptic Density Neuronal Cell Body Dendritic Spine Sperm Head Extracellular Exosome Glutamatergic Synapse
	Molecular Function	Protein Kinase Inhibitor Activity Protein Kinase Binding Chaperone Binding Misfolded Protein Binding	ATPase Activator Activity Transcription Corepressor Activity Protein Binding Hsp70 Protein Binding Protein Folding Chaperone Cadherin Binding Unfolded Protein Binding Chaperone Binding ATPase Binding
	Biological Process	Negative Regulation Of Protein Kinase Activity Protein Folding In Endoplasmic Reticulum Positive Regulation Of Translation Initiation In Response To Endoplasmic Reticulum Stress IRE1-mediated Unfolded Protein Response Negative Regulation Of Apoptotic Process Neutrophil Degranulation Post-translational Protein Modification Cellular Protein Metabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Defense Response To Virus Cellular Response To Cold Negative Regulation Of Endoplasmic Reticulum Stress-induced EIF2 Alpha Phosphorylation	Negative Regulation Of Transcription By RNA Polymerase II Response To Unfolded Protein Forebrain Development Positive Regulation Of ATPase Activity Chaperone Cofactor-dependent Protein Refolding Negative Regulation Of Inclusion Body Assembly Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of Cellular Response To Heat
Pathways		Viral mRNA Translation XBP1(S) activates chaperone genes Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Neutrophil degranulation Post-translational protein phosphorylation	Regulation of HSF1-mediated heat shock response HSP90 chaperone cycle for steroid hormone receptors (SHR) Attenuation phase HSF1-dependent transactivation MAPK6/MAPK4 signaling
Drugs
Diseases
GWAS		Body mass index ( 28552196)	Adventurousness ( 30643258) General risk tolerance (MTAG) ( 30643258)
Interacting Genes		7 interacting genes: DNAJB1 EIF2AK2 EIF2AK3 HSPA1A HSPA5 THAP12 TIRAP	33 interacting genes: A2M AKT1 ANK2 APP BDKRB1 BRCA1 BRMS1 CENPE CYP2C8 DNAJA2 DNAJC3 ECSIT FANCA FANCC GLB1 HSF1 HSPA1A HSPA4 HSPA8 MAST1 NQO1 NRAS PEA15 PLEKHO1 PSEN2 PTGES3 SOD1 SPP1 STUB1 TERF1 TP53 TTLL12 ZFP36
Entrez ID		5611	3337
HPRD ID		03114	05198
Ensembl ID		ENSG00000102580	ENSG00000132002
Uniprot IDs		A8KA82 Q13217	P25685 Q6FHS4
PDB IDs		2Y4T 2Y4U	1HDJ 2QLD 3AGX 3AGY 3AGZ 4WB7 6BYR
Enriched GO Terms of Interacting Partners?
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