MAPK13 and ANKLE2

Data Source:
BioGRID (two hybrid)

		MAPK13	ANKLE2
Description		mitogen-activated protein kinase 13	ankyrin repeat and LEM domain containing 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Endoplasmic Reticulum Membrane
	Molecular Function	Protein Serine/threonine Kinase Activity MAP Kinase Activity Protein Binding ATP Binding	Protein Binding Protein Phosphatase Regulator Activity Protein Phosphatase 2A Binding
	Biological Process	Response To Osmotic Stress Cell Cycle Peptidyl-serine Phosphorylation Positive Regulation Of Interleukin-6 Production Cellular Response To UV Intracellular Signal Transduction Positive Regulation Of Inflammatory Response Stress-activated MAPK Cascade Cellular Response To Hydrogen Peroxide Cellular Response To Interleukin-1 Cellular Response To Sorbitol Cellular Response To Anisomycin Cellular Response To Sodium Arsenite	Mitotic Nuclear Envelope Reassembly Central Nervous System Development Positive Regulation Of Protein Dephosphorylation Negative Regulation Of Phosphorylation Negative Regulation Of Apoptotic Process Regulation Of Phosphoprotein Phosphatase Activity Regulation Of Catalytic Activity Cell Division
Pathways		NOD1/2 Signaling Pathway p38MAPK events DSCAM interactions VEGFA-VEGFR2 Pathway	Initiation of Nuclear Envelope (NE) Reformation
Drugs		Minocycline KC706 Fostamatinib
Diseases
GWAS		Birth weight ( 31043758) Blood protein levels ( 30072576 29875488) Offspring birth weight ( 31043758)	Adult body size ( 32376654) Immune response to smallpox vaccine (IL-6) ( 22542470) Lymphocyte counts ( 32888494) Monocyte count ( 32888494) Refractive error ( 32231278)
Interacting Genes		16 interacting genes: AKIP1 ANKLE2 APP ATF2 EEF2K FGF12 GPX4 HTRA2 MAP2K6 MAP3K4 MAPKAPK3 MAPKAPK5 MAPT MBP SMAD4 SQSTM1	3 interacting genes: MAPK13 ZFYVE9 ZNF512B
Entrez ID		5603	23141
HPRD ID		09113	19309
Ensembl ID		ENSG00000156711	ENSG00000176915
Uniprot IDs		A0A024RD04 O15264	Q86XL3
PDB IDs		3COI 4EYJ 4EYM 4MYG 4YNO 5EKN 5EKO
Enriched GO Terms of Interacting Partners?
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