MAPK11 and ZNHIT1

Data Source:
HPRD (two hybrid)

		MAPK11	ZNHIT1
Description		mitogen-activated protein kinase 11	zinc finger HIT-type containing 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Swr1 Complex Nucleus Nucleoplasm
	Molecular Function	Protein Serine/threonine Kinase Activity MAP Kinase Activity Protein Binding ATP Binding	Protein Binding Nucleosome Binding Metal Ion Binding
	Biological Process	Activation Of MAPK Activity Protein Phosphorylation Ras Protein Signal Transduction Positive Regulation Of Gene Expression Positive Regulation Of Interleukin-12 Production Intracellular Signal Transduction Positive Regulation Of Erythrocyte Differentiation Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Muscle Cell Differentiation Stress-activated MAPK Cascade Negative Regulation Of Cardiac Muscle Cell Proliferation Cellular Response To Interleukin-1 Cellular Response To Virus Regulation Of Signal Transduction By P53 Class Mediator	Histone Exchange
Pathways		NOD1/2 Signaling Pathway p38MAPK events p38MAPK events ERK/MAPK targets Activation of PPARGC1A (PGC-1alpha) by phosphorylation Oxidative Stress Induced Senescence DSCAM interactions VEGFA-VEGFR2 Pathway activated TAK1 mediates p38 MAPK activation Activation of the AP-1 family of transcription factors KSRP (KHSRP) binds and destabilizes mRNA Myogenesis Myogenesis RHO GTPases Activate NADPH Oxidases Regulation of TP53 Activity through Phosphorylation
Drugs		Minocycline KC706 Regorafenib
Diseases
GWAS		Acne (severe) ( 24927181) Adult body size ( 32376654)
Interacting Genes		27 interacting genes: APP ATF2 BCL2 C9orf78 CCND1 CPNE6 DUSP10 DUSP16 EEF2K ELK1 ELK4 ESR2 HDAC3 HTRA2 JUN MAPKAPK5 MAPT MBP NOXA1 PML POLR3D PPM1D RPS6KA5 SH2D1A SOCS3 TAB1 ZNHIT1	22 interacting genes: BCL6 COL8A1 CSNK2B CYSRT1 DAPP1 FHL5 GOLGA6L9 GRB7 HINFP KANK2 KRTAP10-6 KRTAP10-7 KRTAP12-2 MAPK11 MAPK14 MAPK9 MDFI MYO5B OTX2 SH2D1A TNIP1 TP53
Entrez ID		5600	10467
HPRD ID		04208	15892
Ensembl ID		ENSG00000185386	ENSG00000106400
Uniprot IDs		Q15759	O43257
PDB IDs		3GC8 3GC9 3GP0
Enriched GO Terms of Interacting Partners?
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