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PRKDC and GSK3A
Data Source:
BioGRID
(enzymatic study)
PRKDC
GSK3A
Description
protein kinase, DNA-activated, catalytic subunit
glycogen synthase kinase 3 alpha
Image
GO Annotations
Cellular Component
Chromosome, Telomeric Region
Nucleus
Nucleoplasm
Transcription Regulator Complex
Nucleolus
Cytosol
DNA-dependent Protein Kinase-DNA Ligase 4 Complex
Membrane
Small-subunit Processome
Protein-containing Complex
Protein-DNA Complex
Nonhomologous End Joining Complex
Nucleus
Cytoplasm
Mitochondrion
Cytosol
Microtubule
Axon
Beta-catenin Destruction Complex
Neuronal Cell Body
Apical Dendrite
Postsynapse
Proximal Dendrite
Molecular Function
Double-stranded DNA Binding
RNA Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
DNA-dependent Protein Kinase Activity
Protein Binding
ATP Binding
Transcription Factor Binding
Enzyme Binding
Protein Domain Specific Binding
U3 SnoRNA Binding
Protein Serine Kinase Activity
Protein Threonine Kinase Activity
Protein Serine/threonine Kinase Activity
Signaling Receptor Binding
Protein Binding
ATP Binding
Protein Kinase A Catalytic Subunit Binding
Tau Protein Binding
Tau-protein Kinase Activity
Protein Serine Kinase Activity
Protein Threonine Kinase Activity
Biological Process
Maturation Of 5.8S RRNA
Telomere Maintenance
Somitogenesis
Negative Regulation Of Protein Phosphorylation
Activation Of Innate Immune Response
B Cell Lineage Commitment
Pro-B Cell Differentiation
T Cell Lineage Commitment
Negative Regulation Of Immunoglobulin Production
Double-strand Break Repair
Double-strand Break Repair Via Nonhomologous End Joining
Cellular Protein Modification Process
Protein Phosphorylation
Cellular Response To DNA Damage Stimulus
Brain Development
Heart Development
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Response To Gamma Radiation
Response To Activity
Telomere Capping
Protein Ubiquitination
Peptidyl-serine Phosphorylation
Peptidyl-threonine Phosphorylation
Protein Destabilization
Positive Regulation Of Type I Interferon Production
Cellular Response To Insulin Stimulus
T Cell Differentiation In Thymus
Immunoglobulin V(D)J Recombination
T Cell Receptor V(D)J Recombination
Small-subunit Processome Assembly
Ectopic Germ Cell Programmed Cell Death
Regulation Of Circadian Rhythm
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Innate Immune Response
Positive Regulation Of Lymphocyte Differentiation
Positive Regulation Of Erythrocyte Differentiation
Positive Regulation Of Translation
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Fibroblast Proliferation
Rhythmic Process
Spleen Development
Thymus Development
Positive Regulation Of Developmental Growth
Regulation Of Smooth Muscle Cell Proliferation
Regulation Of Epithelial Cell Proliferation
Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint
Double-strand Break Repair Via Alternative Nonhomologous End Joining
Regulation Of Hematopoietic Stem Cell Differentiation
Positive Regulation Of Platelet Formation
Negative Regulation Of Cellular Senescence
Positive Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Negative Regulation Of Response To Gamma Radiation
Regulation Of Systemic Arterial Blood Pressure
Cardiac Left Ventricle Morphogenesis
Glycogen Metabolic Process
Regulation Of Gene Expression By Genetic Imprinting
Protein Phosphorylation
Signal Transduction
Dopamine Receptor Signaling Pathway
Nervous System Development
Aging
Insulin Receptor Signaling Pathway
Positive Regulation Of Autophagy
Positive Regulation Of Gene Expression
Positive Regulation Of Peptidyl-threonine Phosphorylation
Negative Regulation Of UDP-glucose Catabolic Process
Regulation Of Neuron Projection Development
Wnt Signaling Pathway
Cell Migration
Peptidyl-serine Phosphorylation
Peptidyl-threonine Phosphorylation
Positive Regulation Of Protein Ubiquitination
Negative Regulation Of TOR Signaling
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Cellular Response To Insulin Stimulus
Positive Regulation Of Peptidyl-serine Phosphorylation
Cellular Response To Interleukin-3
IRE1-mediated Unfolded Protein Response
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Neuron Apoptotic Process
Hypermethylation Of CpG Island
Negative Regulation Of Glycogen Biosynthetic Process
Positive Regulation Of Protein Catabolic Process
Positive Regulation Of Heart Contraction
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Glucose Import
Negative Regulation Of Insulin Receptor Signaling Pathway
Excitatory Postsynaptic Potential
Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development
Cellular Response To Lithium Ion
Positive Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway
Negative Regulation Of Canonical Wnt Signaling Pathway
Extrinsic Apoptotic Signaling Pathway
Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Positive Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway
Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway
Positive Regulation Of Amyloid-beta Formation
Regulation Of Autophagy Of Mitochondrion
Positive Regulation Of Protein Targeting To Mitochondrion
Negative Regulation Of Glycogen Synthase Activity, Transferring Glucose-1-phosphate
Negative Regulation Of Type B Pancreatic Cell Development
Negative Regulation Of Dendrite Development
Negative Regulation Of Glycogen (starch) Synthase Activity
Positive Regulation Of Glycogen (starch) Synthase Activity
Pathways
Cytosolic sensors of pathogen-associated DNA
IRF3-mediated induction of type I IFN
Nonhomologous End-Joining (NHEJ)
E3 ubiquitin ligases ubiquitinate target proteins
AKT phosphorylates targets in the cytosol
XBP1(S) activates chaperone genes
Constitutive Signaling by AKT1 E17K in Cancer
Suppression of apoptosis
Replication of the SARS-CoV-1 genome
Replication of the SARS-CoV-2 genome
Drugs
Caffeine
SF1126
Fostamatinib
Diseases
GWAS
Adult body size (
32376654
)
Hemoglobin (
32888494
)
Mean corpuscular hemoglobin (
32888494
)
Meat-related diet (
32066663
)
Interacting Genes
91 interacting genes:
ABL1
AICDA
AKT1
AKT2
AP1B1
ATM
ATRIP
BRCA1
C1D
CASP3
CCNB1
CHEK1
CHEK2
CHUK
CIB1
CLK1
CTDP1
DCAF1
DCLRE1C
DUX4
E4F1
EIF2S2
EIF4EBP1
EP300
ERG
FH
GSK3A
GSK3B
GZMB
H1-1
H1-2
H2AX
HDAC3
HMGB1
HMGB2
HNRNPA1
HNRNPC
HOXC4
HSF1
HSP90AA1
IKBKB
ILF2
JUN
KAT2A
LIG4
LYN
MAPK8
MBP
MKNK1
MRE11
MTNR1B
NBN
NCF1
NCF2
NCF4
NCOA6
NR3C1
PARP1
PCNA
PDX1
PGR
POU2F1
PPP6C
PPP6R1
PPP6R3
PRKCD
PTEN
RAD17
RASSF1
RBBP8
RPA1
RPA2
SGO1
SP1
SRF
SUMO2
THRA
THRB
TOP1
TP53
TREX1
UBE2I
USF1
WRN
XPA
XRCC4
XRCC5
XRCC6
YWHAG
YWHAQ
ZBTB7A
34 interacting genes:
AKT1
BCL2L1
BCL3
BICD1
CREB1
CREM
DEAF1
EBNA1BP2
EIF2B5
FAM193B
GLI3
GSKIP
HSF1
LRSAM1
MAPT
MCL1
MYC
NBR1
PRKACA
PRKCA
PRKCB
PRKCD
PRKCG
PRKCH
PRKCZ
PRKD3
PRKDC
PXN
RICTOR
SGK1
SGK3
SPG21
STAT2
YWHAG
Entrez ID
5591
2931
HPRD ID
02941
06002
Ensembl ID
ENSG00000253729
ENSG00000105723
Uniprot IDs
P78527
A0A024R0L5
P49840
PDB IDs
5LUQ
5W1R
5Y3R
6ZFP
6ZH2
6ZH4
6ZH6
6ZH8
6ZHA
6ZHE
2DFM
Enriched GO Terms of Interacting Partners
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