PBK and TRIM37

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PBK	TRIM37
Description		PDZ binding kinase	tripartite motif containing 37
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GO Annotations	Cellular Component	Nucleus	Cytoplasm Peroxisome Cytosol Aggresome ESC/E(Z) Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Serine/threonine Kinase Activity MAP Kinase Kinase Activity Protein Binding ATP Binding	Chromatin Binding Transcription Coactivator Activity Ubiquitin-protein Transferase Activity Tumor Necrosis Factor Receptor Binding Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Binding Protein Homodimerization Activity Ubiquitin Protein Ligase Activity
	Biological Process	MAPK Cascade Activation Of MAPK Activity Mitotic Cell Cycle Negative Regulation Of Protein Phosphorylation Protein Phosphorylation Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Stress-activated MAPK Cascade Cellular Response To UV Negative Regulation Of Inflammatory Response	Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of NF-kappaB Transcription Factor Activity Histone H2A Monoubiquitination Histone H2A-K119 Monoubiquitination Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Centriole Replication Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Autoubiquitination Aggresome Assembly
Pathways			Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS			Cognitive function ( 25644384) General cognitive ability ( 29844566) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Refractive error ( 32231278) Testicular germ cell tumor ( 23666239)
Interacting Genes		19 interacting genes: ARAF CCNB1 CDK1 CEP126 DLG1 GPRASP1 GPS2 H2AX LNX1 MCRS1 PTEN RAF1 SMAD4 TERT TP53 TRIM37 ZBTB26 ZFP64 ZNF526	73 interacting genes: ANKRD11 APEX2 APTX AQP1 ARNT2 AXIN1 BYSL CCDC33 CDC20B CDC7 CDK5RAP2 CDKL3 COPB1 CWF19L2 DDX6 DLGAP5 DTNB DZIP1L ELOA ELOA2 EWSR1 FAM107A FAM124B FAM161A FAM50B FXR2 H2AC20 H2AC4 IKBKG KAT5 KIAA0408 KIF9 LTBR MAGEB18 MCM10 MCRS1 NGFR NUDT18 PBK PNKP PRC1 RASD1 RHPN1 RIBC2 RNF6 RPL9 RXRB SCNM1 SYTL4 TCEANC TNFRSF1B TRAF1 TRAF2 TRAF3 TRAF4 TRAF5 TRAF6 UBASH3A UBB UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E2 UBE2E3 UBE2H UBE2U ZBTB24 ZMAT2 ZNF329 ZNF417 ZNF587 ZNF655
Entrez ID		55872	4591
HPRD ID		17822	05463
Ensembl ID		ENSG00000168078	ENSG00000108395
Uniprot IDs		Q96KB5 V9HWH0	O94972
PDB IDs		5J0A	3LRQ
Enriched GO Terms of Interacting Partners?
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