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PKN1 and KRT19
Data Source:
BioGRID
(two hybrid)
PKN1
KRT19
Description
protein kinase N1
keratin 19
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Endosome
Cytosol
Midbody
Cleavage Furrow
Protein-containing Complex
Cytosol
Intermediate Filament
Plasma Membrane
Dystrophin-associated Glycoprotein Complex
Apicolateral Plasma Membrane
Z Disc
Sarcolemma
Costamere
Extracellular Exosome
Cell Periphery
Terminal Web
Molecular Function
Chromatin Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Calcium-dependent Protein Kinase C Activity
Protein Kinase C Binding
Protein Binding
ATP Binding
Nuclear Receptor Coactivator Activity
Small GTPase Binding
Histone Kinase Activity (H3-T11 Specific)
Histone Binding
Histone Deacetylase Binding
Androgen Receptor Binding
Structural Constituent Of Cytoskeleton
Protein Binding
Structural Constituent Of Muscle
Protein-containing Complex Binding
Biological Process
B Cell Homeostasis
B Cell Apoptotic Process
Regulation Of Germinal Center Formation
Regulation Of Immunoglobulin Production
Renal System Process
Regulation Of Transcription By RNA Polymerase II
Protein Phosphorylation
Negative Regulation Of Protein Kinase Activity
Hyperosmotic Response
Signal Transduction
Activation Of JUN Kinase Activity
Epithelial Cell Migration
Peptidyl-serine Phosphorylation
Negative Regulation Of B Cell Proliferation
Histone H3-T11 Phosphorylation
Intracellular Signal Transduction
Positive Regulation Of Transcription, DNA-templated
Spleen Development
Regulation Of Cell Motility
Notch Signaling Pathway
Viral Process
Keratinization
Response To Estrogen
Sarcomere Organization
Cell Differentiation Involved In Embryonic Placenta Development
Cornification
Pathways
RHO GTPases activate PKNs
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Keratinization
Formation of the cornified envelope
Drugs
Fostamatinib
Diseases
GWAS
Pancreatic cancer (
30206226
)
Urolithiasis (
30975718
)
Interacting Genes
83 interacting genes:
ACTN1
ADAMTSL4
AKAP9
ARHGAP10
ARHGAP26
ARSA
BLZF1
BUD23
CASP3
CCDC103
CCDC136
CCDC138
CCDC85B
CCNT2
CD44
CDC25C
CDR2
CEP57
CEP57L1
CEP70
CYSRT1
DISC1
DYDC1
EIF3F
GOLGA2
GOLGA6L9
H3C14
HAP1
HAUS1
HDAC5
HOMER3
HSF2BP
INTS11
KIAA1328
KRT15
KRT16
KRT19
KRT31
KRT34
KRT35
KRT36
KRT37
LRRC61
MAP2K6
MAPK12
MAPT
MARCKS
MBP
MID1
MID2
MIPOL1
MKRN3
MTDH
MTUS2
NEFH
NEFL
NEUROD2
PDPK1
PICK1
PLD1
PNMA1
POU6F2
PSMB4
RAB3IP
RHOA
SERTAD3
SMYD3
SPAG5
SPRR2D
SSX2IP
STX11
SYCE3
TNFRSF1B
TRAF1
TRAF2
TRIM27
TSGA10
UBR2
USHBP1
VIM
ZFAND6
ZNF282
ZRANB1
79 interacting genes:
ABI2
AMOT
AMOTL2
APC
ARL4A
BEX2
C1orf109
CARD9
CCDC146
CCHCR1
CEP57L1
COPS4
DEPP1
DGCR6L
DMD
EIF4E2
EIF4ENIF1
ESR1
EXOC8
FAM107A
FAM124B
FANCG
GFAP
GLYCTK
HAUS1
HGS
IKZF3
KDM1A
KIFC3
KRT1
KRT15
KRT2
KRT3
KRT4
KRT5
KRT6A
KRT6B
KRT6C
KRT71
KRT72
KRT74
KRT75
KRT77
KRT78
KRT79
KRT8
KRT80
KRT81
KRT83
KRT85
KRT86
LENG1
LGALS14
NFKBID
PCDHB12
PCM1
PKN1
PLEKHA5
PNN
POLL
POLR1C
PPP1R18
PRPH
PSMA1
RCOR3
SFI1
SGF29
SMARCB1
SMARCE1
SNAPIN
SPG21
TBC1D7
TCHP
TFPT
TUBG1
UBE2I
UCHL5
USHBP1
ZNF638
Entrez ID
5585
3880
HPRD ID
03019
01007
Ensembl ID
ENSG00000123143
ENSG00000171345
Uniprot IDs
Q16512
P08727
PDB IDs
1CXZ
1URF
2RMK
4NKG
4OTD
4OTG
4OTH
4OTI
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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