CENPJ and LAG3

Data Source:
HPRD (in vivo, in vitro, two hybrid)

		CENPJ	LAG3
Description		centromere protein J	lymphocyte activating 3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Centrosome Centriole Cytosol Microtubule Plasma Membrane Gamma-tubulin Small Complex	Extracellular Region Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane
	Molecular Function	Transcription Coactivator Activity Protein Binding Tubulin Binding Protein Kinase Binding Protein Domain Specific Binding Identical Protein Binding Gamma-tubulin Binding	Antigen Binding Transmembrane Signaling Receptor Activity Protein Binding MHC Class II Protein Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Microtubule Nucleation Centriole Replication Regulation Of G2/M Transition Of Mitotic Cell Cycle Astral Microtubule Nucleation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Regulation Of Centriole Replication Microtubule Polymerization Cell Division Cilium Assembly Centriole Elongation Ciliary Basal Body-plasma Membrane Docking Positive Regulation Of Centriole Elongation Positive Regulation Of Establishment Of Protein Localization	Adaptive Immune Response Plasmacytoid Dendritic Cell Activation Cell Surface Receptor Signaling Pathway Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Negative Regulation Of Interleukin-2 Production Negative Regulation Of Regulatory T Cell Differentiation Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Immune Response
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain AURKA Activation by TPX2	MHC class II antigen presentation
Drugs
Diseases		Seckel syndrome Primary microcephaly (MCPH)
GWAS			Blood protein levels ( 30072576)
Interacting Genes		15 interacting genes: ATN1 BCCIP CIC CREBBP EPB41 FBXO7 GFI1B LAG3 LYST MTDH STAT5A STAT5B TUBG1 YWHAG YWHAZ	2 interacting genes: CEBPZ CENPJ
Entrez ID		55835	3902
HPRD ID		09876	01077
Ensembl ID		ENSG00000151849	ENSG00000089692
Uniprot IDs		A8K8P1 F6VUX8 Q9HC77	P18627
PDB IDs		5EIB 5ITZ
Enriched GO Terms of Interacting Partners?
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