ADCY10 and PTGIR

Data Source:
HPRD (in vitro)

		ADCY10	PTGIR
Description		adenylate cyclase 10	prostaglandin I2 receptor
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleus Cytoplasm Mitochondrion Cytosol Microtubule Cytoskeleton Apical Plasma Membrane Dendrite Growth Cone Motile Cilium Neuronal Cell Body Basal Part Of Cell Perinuclear Region Of Cytoplasm	Cytosol Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Magnesium Ion Binding Adenylate Cyclase Activity ATP Binding Manganese Ion Binding ATPase Binding Bicarbonate Binding	Guanyl-nucleotide Exchange Factor Activity Prostacyclin Receptor Activity
	Biological Process	Epithelial Cilium Movement Involved In Extracellular Fluid Movement CAMP Biosynthetic Process Spermatogenesis Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Cellular Response To Inorganic Substance	Inflammatory Response G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Cell-cell Signaling Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Response To Lipopolysaccharide Negative Regulation Of Smooth Muscle Cell Proliferation Regulation Of Catalytic Activity
Pathways		Hedgehog 'off' state	Prostanoid ligand receptors Prostacyclin signalling through prostacyclin receptor Prostacyclin signalling through prostacyclin receptor G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production
Drugs			Treprostinil Iloprost Dinoprost tromethamine Epoprostenol Beraprost Selexipag
Diseases
GWAS			Crohn's disease ( 28067908)
Interacting Genes		2 interacting genes: PTGIR SSTR5	10 interacting genes: ADCY10 GNA11 GNAQ GNAS LNX1 PDE6D PDZD3 PRKCA RAB11A TBXA2R
Entrez ID		55811	5739
HPRD ID		05549	08959
Ensembl ID		ENSG00000143199	ENSG00000160013
Uniprot IDs		A0A0K0K1J8 Q96PN6	P43119
PDB IDs		4CLF 4CLK 4CLL 4CLP 4CLS 4CLT 4CLU 4CLW 4CLY 4CLZ 4CM0 4CM2 4OYA 4OYB 4OYI 4OYM 4OYO 4OYP 4OYW 4OYX 4OYZ 4OZ2 4OZ3 4UST 4USU 4USV 4USW 5D0R 5IV3 5IV4
Enriched GO Terms of Interacting Partners?
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