CHFR and ITGAE

Data Source:
HPRD (two hybrid)

		CHFR	ITGAE
Description		checkpoint with forkhead and ring finger domains	integrin subunit alpha E
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus PML Body	Plasma Membrane Integrin Complex External Side Of Plasma Membrane
	Molecular Function	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Metal Ion Binding
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Mitotic Cell Cycle Checkpoint Protein Ubiquitination Modification-dependent Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Protein Destabilization Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Meiotic Spindle Checkpoint Cell Division	Cell Adhesion Integrin-mediated Signaling Pathway Extracellular Matrix Organization
Pathways			Integrin cell surface interactions
Drugs
Diseases
GWAS		Cognitive function ( 24684796) Height ( 31562340) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Refractive error ( 32231278) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258) Systolic blood pressure x quantitative lifestyle risk score interaction (1df test) ( 32227373) Systolic blood pressure x quantitative lifestyle risk score interaction (2df test) ( 32227373)	Attention deficit hyperactivity disorder ( 18839057)
Interacting Genes		30 interacting genes: AURKA BRD4 CBLC EEF1G GABBR1 GRB10 GRB14 HDAC1 HDAC2 ITGAE PML RNF125 RNF7 SIRT1 SMARCA4 SMARCB1 SMARCD1 TRIM9 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2I UBE2L1 UBE2N UBE2W WDR47	5 interacting genes: CDH1 CHFR EED ITGB7 TRIM54
Entrez ID		55743	3682
HPRD ID		05552	05249
Ensembl ID		ENSG00000072609	ENSG00000083457
Uniprot IDs		Q96EP1	P38570
PDB IDs		1LGP 1LGQ 2XOC 2XOY 2XOZ 2XP0
Enriched GO Terms of Interacting Partners?
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