PARVA and FERMT3

Data Source:
BioGRID (pull down)

		PARVA	FERMT3
Description		parvin alpha	FERM domain containing kindlin 3
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Focal Adhesion Actin Cytoskeleton Z Disc Lamellipodium	Podosome Extracellular Region Membrane Cell-substrate Junction Platelet Alpha Granule Lumen Cell Projection Extracellular Exosome
	Molecular Function	Actin Binding Protein Kinase Inhibitor Activity Protein Binding Cadherin Binding	Integrin Binding
	Biological Process	Sprouting Angiogenesis Outflow Tract Septum Morphogenesis Negative Regulation Of Protein Kinase Activity Establishment Or Maintenance Of Cell Polarity Regulation Of Cell Shape Cell Projection Assembly Actin Cytoskeleton Reorganization Heterotypic Cell-cell Adhesion Substrate Adhesion-dependent Cell Spreading Protein Stabilization Cilium Assembly Actin-mediated Cell Contraction Smooth Muscle Cell Chemotaxis	Platelet Degranulation Leukocyte Cell-cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Positive Regulation Of Cell Migration Integrin Activation Regulation Of Cell-cell Adhesion Mediated By Integrin Substrate Adhesion-dependent Cell Spreading Platelet Aggregation
Pathways		Localization of the PINCH-ILK-PARVIN complex to focal adhesions Cell-extracellular matrix interactions Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	Platelet degranulation
Drugs
Diseases			Leukocyte adhesion deficiency (LAD), including the following four diseases: Leukocyte adhesion deficiency (I); Leukocyte adhesion deficiency (II); Leukocyte adhesion deficiency (III); LAD with Rac2 deficiency
GWAS		Depressive symptoms (SSRI exposure interaction) ( 25649181) Diisocyanate-induced asthma ( 25918132) Epstein-Barr virus copy number in lymphoblastoid cell lines ( 28654678) HOMA-B (corrected for HOMA-IR) ( 30369944) Lung adenocarcinoma ( 28604730) Mortality in heart failure ( 20400778)	Attention deficit hyperactivity disorder ( 21784300) Crohn's disease ( 28067908) Fruit consumption ( 32066663) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Immature fraction of reticulocytes ( 32888494 27863252) Mean platelet volume ( 32888494) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (HMG CoA reductase inhibitors) ( 31015401)
Interacting Genes		14 interacting genes: ACTA1 APP FERMT1 FERMT2 FERMT3 HSPB2 ILK LIMS1 MAP2K1 MLH1 NFE2L1 PXN UBE3A UBQLN1	11 interacting genes: ANKRD29 APP EXOSC10 ILK ITGB1 LIMS1 LSM8 PARVA PRPF18 TINF2 TRIM15
Entrez ID		55742	83706
HPRD ID		16283	07440
Ensembl ID		ENSG00000197702	ENSG00000149781
Uniprot IDs		Q9NVD7	Q86UX7
PDB IDs		2K2R 2VZC 2VZD 2VZG 2VZI 3KMU 3KMW 3REP 6MIB	2YS3 6V97 6V9G 7C3M
Enriched GO Terms of Interacting Partners?
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