EDEM2 and TRPC4AP

Data Source:
BioGRID (biochemical)

		EDEM2	TRPC4AP
Description		ER degradation enhancing alpha-mannosidase like protein 2	transient receptor potential cation channel subfamily C member 4 associated protein
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Lumen Membrane Endoplasmic Reticulum Quality Control Compartment	Plasma Membrane Cul4A-RING E3 Ubiquitin Ligase Complex
	Molecular Function	Mannosyl-oligosaccharide 1,2-alpha-mannosidase Activity Calcium Ion Binding	Protein Binding Phosphatase Binding
	Biological Process	Carbohydrate Metabolic Process Response To Unfolded Protein Trimming Of Terminal Mannose On B Branch Trimming Of Terminal Mannose On C Branch Trimming Of First Mannose On A Branch Trimming Of Second Mannose On A Branch Ubiquitin-dependent Glycoprotein ERAD Pathway Positive Regulation Of Retrograde Protein Transport, ER To Cytosol Mannose Trimming Involved In Glycoprotein ERAD Pathway	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Hair Follicle Maturation Calcium Ion Transmembrane Transport
Pathways		ER Quality Control Compartment (ERQC) Maturation of spike protein	TRP channels
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Birth weight ( 31043758) Blood protein levels ( 28240269) Estimated glomerular filtration rate ( 31152163) Fish- and plant-related diet ( 32066663) HDL cholesterol ( 30275531) Hemostatic factors and hematological phenotypes ( 22443383) Offspring birth weight ( 31043758) Protein C levels ( 28082259 20802025) Prothrombin time ( 22703881) QRS complex (Cornell) ( 27659466) Venous thromboembolism ( 31676865) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Blood protein levels ( 28240269) Fish- and plant-related diet ( 32066663) HDL cholesterol levels ( 32203549) Heel bone mineral density ( 30598549) Prothrombin time ( 22703881) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		1 interacting genes: RPS3A	10 interacting genes: CHMP4C CHUK IKBKB IKBKG MTDH RIPK1 TAB1 TNFRSF1A TRADD TRAF2
Entrez ID		55741	26133
HPRD ID		09841	09238
Ensembl ID		ENSG00000088298	ENSG00000100991
Uniprot IDs		Q9BV94	B4DW48 Q8TEL6
PDB IDs
Enriched GO Terms of Interacting Partners?
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