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TRPC4AP and IKBKB
Data Source:
HPRD
(in vitro)
TRPC4AP
IKBKB
Description
transient receptor potential cation channel subfamily C member 4 associated protein
inhibitor of nuclear factor kappa B kinase subunit beta
Image
No pdb structure
GO Annotations
Cellular Component
Plasma Membrane
Cul4A-RING E3 Ubiquitin Ligase Complex
Nucleus
Cytoplasm
Cytosol
IkappaB Kinase Complex
Cytoplasmic Side Of Plasma Membrane
CD40 Receptor Complex
Membrane Raft
Molecular Function
Protein Binding
Phosphatase Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
IkappaB Kinase Activity
Protein Kinase Binding
Identical Protein Binding
Protein Homodimerization Activity
Protein Heterodimerization Activity
Scaffold Protein Binding
Protein Serine Kinase Activity
Protein Threonine Kinase Activity
Transferrin Receptor Binding
Biological Process
Ubiquitin-dependent Protein Catabolic Process
Protein Ubiquitination
Hair Follicle Maturation
Calcium Ion Transmembrane Transport
Stimulatory C-type Lectin Receptor Signaling Pathway
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent
MyD88-independent Toll-like Receptor Signaling Pathway
Protein Phosphorylation
Inflammatory Response
I-kappaB Kinase/NF-kappaB Signaling
I-kappaB Phosphorylation
Response To Virus
Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Viral Process
Peptidyl-serine Phosphorylation
Cortical Actin Cytoskeleton Organization
Tumor Necrosis Factor-mediated Signaling Pathway
Negative Regulation Of Myosin-light-chain-phosphatase Activity
TRIF-dependent Toll-like Receptor Signaling Pathway
Fc-epsilon Receptor Signaling Pathway
Regulation Of Phosphorylation
Negative Regulation Of Apoptotic Process
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Innate Immune Response
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
T Cell Receptor Signaling Pathway
Positive Regulation Of NF-kappaB Transcription Factor Activity
Stress-activated MAPK Cascade
Interleukin-1-mediated Signaling Pathway
Cellular Response To Tumor Necrosis Factor
Protein Localization To Plasma Membrane
Regulation Of Establishment Of Endothelial Barrier
Negative Regulation Of Bicellular Tight Junction Assembly
Pathways
TRP channels
Activation of NF-kappaB in B cells
Activation of NF-kappaB in B cells
ER-Phagosome pathway
NOD1/2 Signaling Pathway
TICAM1, RIP1-mediated IKK complex recruitment
RIP-mediated NFkB activation via ZBP1
Downstream TCR signaling
p75NTR recruits signalling complexes
NF-kB is activated and signals survival
FCERI mediated NF-kB activation
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
Regulation of TNFR1 signaling
TNFR1-induced NFkappaB signaling pathway
IKBKB deficiency causes SCID
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR)
IkBA variant leads to EDA-ID
CLEC7A (Dectin-1) signaling
MAP3K8 (TPL2)-dependent MAPK1/3 activation
Interleukin-1 signaling
TRAF6 mediated NF-kB activation
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
IRAK1 recruits IKK complex
IKK complex recruitment mediated by RIP1
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
Drugs
Mesalazine
Sulfasalazine
Acetylsalicylic acid
Auranofin
Arsenic trioxide
MLN0415
Acetylcysteine
Ertiprotafib
Fostamatinib
Diseases
GWAS
Blood protein levels (
28240269
)
Fish- and plant-related diet (
32066663
)
HDL cholesterol levels (
32203549
)
Heel bone mineral density (
30598549
)
Prothrombin time (
22703881
)
Waist-to-hip ratio adjusted for BMI (
26426971
)
Waist-to-hip ratio adjusted for BMI (age >50) (
26426971
)
Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) (
26426971
)
Interacting Genes
10 interacting genes:
CHMP4C
CHUK
IKBKB
IKBKG
MTDH
RIPK1
TAB1
TNFRSF1A
TRADD
TRAF2
87 interacting genes:
ACVR1
AKT1
AURKA
CASP8
CCAR2
CDC37
CFLAR
CHUK
COPS3
COPS4
CSF2RA
CSF2RB
CTNNB1
CUEDC2
E2F4
EIF2AK2
EIF2AK3
ELP1
FAF1
FANCA
FOXO3
GLI1
HSP90AA1
HSP90AB1
HTT
IKBKG
IRS1
JUN
KLHL21
MAP3K1
MAP3K11
MAP3K13
MAP3K14
MAP3K3
MAP3K7
MAVS
MTDH
NAA20
NCOA3
NEDD4L
NFKB1
NFKB2
NFKBIA
NFKBIB
NR2C2
PEBP1
PELI1
PLK1
PPARG
PPM1B
PPP2R3C
PRKCA
PRKCB
PRKCD
PRKCE
PRKCQ
PRKCZ
PRKDC
RELA
RICTOR
RIPK1
ROCK1
SASH1
SQSTM1
SRC
STAP2
TAB2
TANK
TBK1
TFAP2C
TGFBR1
TNFAIP3
TNFRSF1A
TP53
TP73
TRAF1
TRAF2
TRAF3IP2
TRIM21
TRIM27
TRPC4AP
TSC1
TWIST1
UBB
UBC
VHL
YWHAB
Entrez ID
26133
3551
HPRD ID
09238
04462
Ensembl ID
ENSG00000100991
ENSG00000104365
Uniprot IDs
B4DW48
Q8TEL6
O14920
PDB IDs
3BRT
3BRV
4E3C
4KIK
Enriched GO Terms of Interacting Partners
?
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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