G2E3 and RPS15

Data Source:
BioGRID (two hybrid)

		G2E3	RPS15
Description		G2/M-phase specific E3 ubiquitin protein ligase	ribosomal protein S15
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleolus Golgi Apparatus Cytosol Intracellular Membrane-bounded Organelle	Nucleus Nucleoplasm Cytosol Focal Adhesion Membrane Cytosolic Small Ribosomal Subunit
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Metal Ion Binding	DNA Binding RNA Binding Structural Constituent Of Ribosome Protein Binding
	Biological Process	Apoptotic Process Multicellular Organism Development Protein Ubiquitination	Ribosomal Small Subunit Assembly Ribosomal Small Subunit Export From Nucleus Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Osteoblast Differentiation RRNA Processing Translation Translational Initiation SRP-dependent Cotranslational Protein Targeting To Membrane Viral Transcription Ribosomal Small Subunit Biogenesis
Pathways			L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS		Cerebral amyloid deposition in APOEe4 non-carriers (PET imaging) ( 26252872) Cognitive decline (age-related) ( 28078323)	Hematocrit ( 32888494) Hemoglobin ( 32888494) Red blood cell count ( 32888494)
Interacting Genes		4 interacting genes: LST1 RPS15 TRIM54 WDR6	11 interacting genes: CDC42 DUX4 ERCC6 G2E3 NAP1L1 PLA2G12A PTEN RAPGEF1 RPS4X SERINC3 UPF2
Entrez ID		55632	6209
HPRD ID		13851	01613
Ensembl ID		ENSG00000092140	ENSG00000115268
Uniprot IDs		B4DL73 F5GX24 Q49AD9 Q7L622	K7ELC2 P62841
PDB IDs			4UG0 4V6X 5A2Q 5AJ0 5FLX 5LKS 5OA3 5T2C 5VYC 6EK0 6FEC 6G18 6G4S 6G4W 6G51 6G53 6G5H 6G5I 6IP5 6IP6 6IP8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP 6XA1 6Y0G 6Y2L 6Y57 6YBS 6Z6L 6Z6M 6Z6N 6ZLW 6ZM7 6ZME 6ZMI 6ZMO 6ZMT 6ZMW 6ZN5 6ZOJ 6ZOL 6ZON 6ZP4 6ZVH 6ZVJ 7A09 7K5I
Enriched GO Terms of Interacting Partners?
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