AMBRA1 and GABARAP

Data Source:
BioGRID (affinity chromatography technology, unspecified method)

		AMBRA1	GABARAP
Description		autophagy and beclin 1 regulator 1	GABA type A receptor-associated protein
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Outer Membrane Autophagosome Cytosol Axoneme Intracellular Membrane-bounded Organelle Phagocytic Vesicle Perinuclear Region Of Cytoplasm	Golgi Membrane Autophagosome Membrane Lysosome Autophagosome Smooth Endoplasmic Reticulum Cytosol Microtubule Microtubule Associated Complex Plasma Membrane Axoneme Actin Cytoskeleton Cytoplasmic Vesicle Cell Body Synapse Perinuclear Region Of Cytoplasm Sperm Midpiece
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Binding GTPase Binding	Protein Binding Microtubule Binding Ubiquitin Protein Ligase Binding Beta-tubulin Binding GABA Receptor Binding
	Biological Process	Autophagosome Assembly Autophagy Of Mitochondrion Mitophagy Autophagy Negative Regulation Of Cell Population Proliferation Cellular Response To Starvation Positive Regulation Of Autophagy Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Macroautophagy Neural Tube Development Cell Differentiation Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Phosphatidylinositol 3-kinase Activity Response To Mitochondrial Depolarisation	Autophagosome Assembly Microtubule Cytoskeleton Organization Autophagy Of Mitochondrion Protein Targeting Cellular Response To Nitrogen Starvation Chemical Synaptic Transmission Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Macroautophagy Autophagosome Maturation
Pathways		Macroautophagy	Macroautophagy TBC/RABGAPs
Drugs
Diseases
GWAS		Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 28552196) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Immunoglobulin A ( 20694011) Insulin-related traits (multivariate analysis) ( 32002517) Normal facial asymmetry (angle of deformation score) ( 30631343) Schizophrenia ( 28991256 29483656 30285260) Selective IgA deficiency ( 27723758)
Interacting Genes		12 interacting genes: BECN1 CHUK GABARAP GABARAPL1 GABARAPL2 MAP1LC3A MAP1LC3B MAP1LC3C MTOR RNF2 SNCA UBE2D3	57 interacting genes: AMBRA1 ANK2 ANK3 ATG101 ATG13 ATG3 ATG4A ATG4B ATG4C ATG4D ATG7 ATXN3 BIRC6 CUL3 DMPK DVL2 FLCN GABRG1 GABRG2 GABRG3 GPHN HDAC5 KBTBD7 KDR LMNB1 MAPK15 MEFV MIB1 MLH1 MPC1 MYBPC2 NBR1 NEDD4 NSF OPTN PCM1 PGS1 PKP4 RB1CC1 SEC62 SNX18 SQSTM1 SRPK1 SRPK2 TAX1BP1 TBC1D25 TFRC TLE5 TP53INP1 TRIM21 TRIM32 TSR2 TTN TUBB3 ULK1 ULK2 VPS28
Entrez ID		55626	11337
HPRD ID		10975	05496
Ensembl ID		ENSG00000110497	ENSG00000170296
Uniprot IDs		A0A075B6T1 Q9C0C7	O95166 Q6IAW1
PDB IDs			1GNU 1KLV 1KM7 1KOT 3D32 3DOW 3WIM 4XC2 5DPS 6HB9 6HOG 6HOH 6HOJ 6HOK 6HYL 6HYM 6HYN 6HYO 7BRQ 7BRT 7BRU 7BV4
Enriched GO Terms of Interacting Partners?
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