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PPT1 and EPS15
Data Source:
BioGRID
(affinity chromatography technology)
PPT1
EPS15
Description
palmitoyl-protein thioesterase 1
epidermal growth factor receptor pathway substrate 15
Image
GO Annotations
Cellular Component
Extracellular Region
Nucleus
Lysosome
Golgi Apparatus
Cytosol
Synaptic Vesicle
Membrane
Axon
Lysosomal Lumen
Intracellular Membrane-bounded Organelle
Membrane Raft
Extracellular Exosome
Cytoplasm
Cytosol
Plasma Membrane
Clathrin-coated Pit
Basal Plasma Membrane
Membrane
Aggresome
Apical Plasma Membrane
Clathrin Coat Of Coated Pit
Early Endosome Membrane
Intracellular Membrane-bounded Organelle
Postsynapse
Glutamatergic Synapse
Molecular Function
Protein Binding
Palmitoyl-(protein) Hydrolase Activity
Palmitoyl-CoA Hydrolase Activity
Thiolester Hydrolase Activity
Lysophosphatidic Acid Binding
Sulfatide Binding
Calcium Ion Binding
Protein Binding
SH3 Domain Binding
Polyubiquitin Modification-dependent Protein Binding
Cadherin Binding
Biological Process
Protein Depalmitoylation
Receptor-mediated Endocytosis
Pinocytosis
Lysosomal Lumen Acidification
Nervous System Development
Brain Development
Visual Perception
Protein Transport
Lipid Catabolic Process
Protein Phosphopantetheinylation
Sphingolipid Catabolic Process
Protein Catabolic Process
Negative Regulation Of Cell Growth
Membrane Raft Organization
Negative Regulation Of Apoptotic Process
Negative Regulation Of Neuron Apoptotic Process
Fatty-acyl-CoA Biosynthetic Process
Positive Regulation Of Receptor-mediated Endocytosis
Positive Regulation Of Pinocytosis
Neuron Development
Regulation Of Synapse Structure Or Activity
Response To Stimulus
Positive Regulation Of Receptor Recycling
Golgi To Endosome Transport
Endocytosis
Vesicle Organization
Endosomal Transport
Receptor-mediated Endocytosis Of Virus By Host Cell
Endocytic Recycling
Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Regulation Of Cell Population Proliferation
Viral Entry Into Host Cell
Clathrin Coat Assembly
Membrane Organization
Postsynaptic Neurotransmitter Receptor Internalization
Pathways
Fatty acyl-CoA biosynthesis
EGFR downregulation
Negative regulation of MET activity
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
InlB-mediated entry of Listeria monocytogenes into host cell
Drugs
Hexadecanesulfonyl fluoride
Palmitic Acid
Diseases
Neuronal ceroid lipofuscinosis, including: Infantile Neuronal Ceroid Lipofuscinosis (INCL)/ Santavuori-Haltia Disease (CLN1); Late-Infantile Neuronal Ceroid Lipofuscinosis (LINCL)/ Jansky-Bielschowsky Disease (CLN2); Juvenile Neuronal Ceroid Lipofuscinosis (JNCL)/Batten Disease/ Spielmeyer-Vogt Disease (CLN3); Adult Neuronal Ceroid Lipofuscinosis (ANCL)/ Kufs Disease (CLN4); LINCL variant (CLN5, CLN6, CLN7, CLN8); Batten Disease variant (CLN9); Congenital NCL (CLN10)
Progressive myoclonic epilepsy (PME), including: Lafora disease (LBD); Unverricht-Lundborg disease (ULD); Neuronal ceroid lipofuscinoses (NCL); Type I sialidosis; Action myoclonus-renal failure syndrome (AMRF); Type III Gaucher disease (GD)
GWAS
Blood protein levels (
30072576
29875488
)
Platelet count (
32888494
)
Blood urea nitrogen levels (
31152163
)
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
IgE grass sensitization (
22036096
)
PR interval (
30046033
32439900
)
Interacting Genes
1 interacting genes:
GNAQ
49 interacting genes:
AGFG1
AGFG2
AP1G1
AP2A1
AP2A2
CLINT1
CORO7
CRK
DNM1
DNM2
EGFR
ELF3
EPN1
EPN2
FCHO1
FCHO2
GRB2
HGS
ITSN1
LAPTM5
MAPK14
MOB4
MTNR1A
NAGPA
NEDD4
NUMB
NUMBL
PRKN
REPS2
RNF11
SCAMP1
SGIP1
SNAP91
SPART
SPOPL
STAM2
STAMBP
STON2
SYNJ1
TFAP2A
UBB
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2E1
UBE2H
UBQLN1
USP8
Entrez ID
5538
2060
HPRD ID
07203
08968
Ensembl ID
ENSG00000131238
ENSG00000085832
Uniprot IDs
P50897
B7Z240
P42566
PDB IDs
3GRO
1C07
1EH2
1F8H
1FF1
2IV9
2JXC
4RH5
4RH9
4RHG
4S0G
5AWT
5AWU
5JP2
Enriched GO Terms of Interacting Partners
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