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FBXW7 and CEBPD
Data Source:
BioGRID
(enzymatic study)
FBXW7
CEBPD
Description
F-box and WD repeat domain containing 7
CCAAT enhancer binding protein delta
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Mitochondrion
Endoplasmic Reticulum
Golgi Apparatus
Cytosol
SCF Ubiquitin Ligase Complex
Perinuclear Region Of Cytoplasm
Parkin-FBXW7-Cul1 Ubiquitin Ligase Complex
Chromatin
Nucleoplasm
Molecular Function
Protein Binding
Cyclin Binding
Protein-macromolecule Adaptor Activity
Ubiquitin Protein Ligase Binding
Identical Protein Binding
Ubiquitin Binding
Phosphothreonine Residue Binding
Ubiquitin-protein Transferase Activator Activity
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
Protein Binding
Sequence-specific Double-stranded DNA Binding
Biological Process
Protein Polyubiquitination
Vasculogenesis
Vasculature Development
Sister Chromatid Cohesion
Notch Signaling Pathway
Negative Regulation Of Gene Expression
Negative Regulation Of Triglyceride Biosynthetic Process
Regulation Of Lipid Storage
Ubiquitin Recycling
Viral Process
Protein Ubiquitination
Lung Development
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Protein Ubiquitination
Protein Destabilization
Regulation Of Protein Localization
Regulation Of Circadian Rhythm
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Post-translational Protein Modification
Positive Regulation Of Epidermal Growth Factor-activated Receptor Activity
Negative Regulation Of Notch Signaling Pathway
Rhythmic Process
Protein Stabilization
Positive Regulation Of Ubiquitin-protein Transferase Activity
Lipid Homeostasis
Positive Regulation Of ERK1 And ERK2 Cascade
Regulation Of Cell Migration Involved In Sprouting Angiogenesis
Positive Regulation Of Proteasomal Protein Catabolic Process
Regulation Of Cell Cycle G1/S Phase Transition
Negative Regulation Of RNA Polymerase II Regulatory Region Sequence-specific DNA Binding
Regulation Of Autophagy Of Mitochondrion
Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of Protein Targeting To Mitochondrion
Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Hepatocyte Proliferation
Negative Regulation Of SREBP Signaling Pathway
Negative Regulation Of Osteoclast Development
Regulation Of Transcription By RNA Polymerase II
Transcription By RNA Polymerase II
Cytokine-mediated Signaling Pathway
Regulation Of Cell Differentiation
Positive Regulation Of Transcription By RNA Polymerase II
Pathways
Association of TriC/CCT with target proteins during biosynthesis
Neddylation
Antigen processing: Ubiquitination & Proteasome degradation
Transcriptional regulation of white adipocyte differentiation
Interleukin-4 and Interleukin-13 signaling
HCMV Late Events
Drugs
Diseases
GWAS
Eosinophil counts (
32888494
)
Eosinophil percentage of white cells (
32888494
)
Basophil count (
32888494
)
Basophil percentage of white cells (
32888494
)
Eosinophil counts (
32888494
27863252
)
Eosinophil percentage of granulocytes (
27863252
)
Eosinophil percentage of white cells (
32888494
27863252
)
Granulocyte percentage of myeloid white cells (
27863252
)
Lymphocyte percentage of white cells (
32888494
)
Monocyte count (
27863252
)
Monocyte percentage of white cells (
32888494
27863252
)
Neutrophil count (
32888494
)
Neutrophil percentage of granulocytes (
27863252
)
Neutrophil percentage of white cells (
32888494
27863252
)
Sum eosinophil basophil counts (
27863252
)
Interacting Genes
77 interacting genes:
AHSG
AKT1
ANGPTL4
ANP32B
ARL6IP1
BCAS3
BEX1
BLM
CCDC6
CCNE1
CCNE2
CDC34
CEBPD
CUL1
DISC1
DVL1
EBNA1BP2
EXT1
EZH2
FANCC
FBP1
FBP2
GALNT12
GATA2
GATA3
GFI1
GLMN
HEMGN
HEY1
HIPK2
HNRNPK
HRAS
IGFBP3
IL24
JUN
KLF10
KLF5
LINGO1
MAP2K1
MAPK3
MMS22L
MYB
MYC
MYCN
NANS
NOTCH1
NOTCH4
NPM1
PLK1
PPARGC1A
PPP3R2
PRKN
PSEN1
PTPN11
RACK1
RFLNA
SCGB3A1
SEC61B
SHC1
SHPRH
SKP1
SMAD1
SOX9
SREBF1
STAT3
STAT5A
STOML1
STYX
SUMF2
TGFB1
TMOD1
TP53
TSC22D4
USP9X
WDR97
XPA
ZNF510
18 interacting genes:
CEBPA
CEBPB
CEBPE
CEBPG
CREBBP
EP300
FBXW7
GSK3B
HDAC3
HDAC4
PIAS4
RB1
RELA
SMAD3
SMAD4
SPI1
TRIB1
UBE2I
Entrez ID
55294
1052
HPRD ID
05888
00297
Ensembl ID
ENSG00000109670
ENSG00000221869
Uniprot IDs
G0Z2K0
Q969H0
S4R3U4
P49716
PDB IDs
2OVP
2OVQ
2OVR
5IBK
5V4B
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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