BBS7 and PAX2

Data Source:
BioGRID (two hybrid)

		BBS7	PAX2
Description		Bardet-Biedl syndrome 7	paired box 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Photoreceptor Outer Segment Nucleus Centrosome Cytosol Axoneme Membrane BBSome Ciliary Basal Body Neuron Projection Ciliary Membrane	Chromatin Nucleus Nucleoplasm Lysosome Microtubule Organizing Center Protein-containing Complex Protein-DNA Complex Centriolar Satellite
	Molecular Function	RNA Polymerase II Repressing Transcription Factor Binding Protein Binding	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA Binding DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Eye Development Heart Looping Regulation Of Transcription By RNA Polymerase II Smoothened Signaling Pathway Determination Of Left/right Symmetry Brain Development Visual Perception Protein Localization Protein Transport Melanosome Transport Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Fat Cell Differentiation Intracellular Transport Digestive Tract Morphogenesis Pigment Granule Aggregation In Cell Center Limb Development Cilium Assembly Primary Palate Development Non-motile Cilium Assembly	Urogenital System Development Branching Involved In Ureteric Bud Morphogenesis Cell Fate Determination Mesonephros Development Neural Tube Closure Optic Cup Morphogenesis Involved In Camera-type Eye Development Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Retinal Pigment Epithelium Development Regulation Of Transcription By RNA Polymerase II Axonogenesis Mesodermal Cell Fate Specification Aging Visual Perception Glial Cell Differentiation Optic Nerve Development Optic Nerve Morphogenesis Optic Nerve Structural Organization Vestibulocochlear Nerve Formation Response To Nutrient Levels Regulation Of Metanephros Size Ureter Maturation Pronephric Field Specification Inner Ear Morphogenesis Camera-type Eye Development Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Protein Kinase B Signaling Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Pronephros Development Brain Morphogenesis Anatomical Structure Development Stem Cell Differentiation Positive Regulation Of Epithelial Cell Proliferation Mesenchymal To Epithelial Transition Optic Chiasma Development Cellular Response To Hydrogen Peroxide Cellular Response To Retinoic Acid Cellular Response To Glucose Stimulus Cellular Response To Epidermal Growth Factor Stimulus Metanephric Mesenchyme Development Positive Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Metanephric Mesenchymal Cell Differentiation Nephric Duct Formation Ureter Development Metanephric Collecting Duct Development Metanephric Epithelium Development Metanephric Distal Convoluted Tubule Development Metanephric Nephron Tubule Formation Positive Regulation Of Metanephric Glomerulus Development Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Metanephric Nephron Morphogenesis Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Reactive Oxygen Species Metabolic Process Cochlea Development Cochlea Morphogenesis Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Metanephros Development Negative Regulation Of Apoptotic Process Involved In Metanephric Collecting Duct Development Negative Regulation Of Apoptotic Process Involved In Metanephric Nephron Tubule Development Negative Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Metanephric DCT Cell Differentiation Positive Regulation Of Optic Nerve Formation
Pathways		BBSome-mediated cargo-targeting to cilium
Drugs
Diseases		Bardet-Biedl syndrome (BBS)	Renal coloboma syndrome (RCS); Papillorenal syndrome
GWAS		Asthma ( 31959851)	Adult body size ( 32376654) Alcohol consumption (drinks per week) ( 30679032) Alzheimer's disease ( 20061627) Bitter alcoholic beverage consumption ( 31046077) BMI (adjusted for smoking behaviour) ( 28443625) Body mass index ( 28892062) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body size at age 10 ( 32376654) Cerebrospinal fluid t-tau:AB1-42 ratio ( 30153862) Diastolic blood pressure ( 27841878) Heart rate increase in response to exercise ( 29497042) Heart rate response to exercise ( 29769521) Heart rate response to recovery post exercise ( 29769521) Heart rate response to recovery post exercise (10 sec) ( 29497042) Heart rate response to recovery post exercise (20 sec) ( 29497042) Heart rate response to recovery post exercise (30 sec) ( 29497042) Heart rate response to recovery post exercise (40 sec) ( 29497042) Heart rate response to recovery post exercise (50 sec) ( 29497042) Refractive error ( 32231278) Regular attendance at a pub or social club ( 29970889) Systolic blood pressure ( 28135244 27841878 30578418)
Interacting Genes		4 interacting genes: FHOD1 JUN KRT18 PAX2	24 interacting genes: BBS1 BBS2 BBS4 BBS7 BEX1 BLID GLCE ID2 IL13RA2 KLK6 KLK9 MAPK8 MAPK8IP1 MRC2 NSD3 PAXIP1 PRDM14 RASL10B RB1 SFRP2 SNAI1 TRIM25 VPS45 WT1
Entrez ID		55212	5076
HPRD ID		07399	01330
Ensembl ID		ENSG00000138686	ENSG00000075891
Uniprot IDs		Q8IWZ6	Q02962
PDB IDs
Enriched GO Terms of Interacting Partners?
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