PBRM1 and CCRL2

Data Source:
BioGRID (affinity chromatography technology)

		PBRM1	CCRL2
Description		polybromo 1	C-C motif chemokine receptor like 2
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Chromosome Nucleoplasm RSC-type Complex	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane
	Molecular Function	DNA Binding Chromatin Binding Protein Binding	Chemokine Receptor Activity C-C Chemokine Receptor Activity C-C Chemokine Binding Chemokine Receptor Binding CCR Chemokine Receptor Binding
	Biological Process	Mitotic Cell Cycle Chromatin Remodeling Negative Regulation Of Cell Population Proliferation ATP-dependent Chromatin Remodeling	Chemotaxis Inflammatory Response Immune Response G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Calcium-mediated Signaling Cell Chemotaxis Chemokine-mediated Signaling Pathway
Pathways		RMTs methylate histone arginines RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	Chemokine receptors bind chemokines
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 21926972 31043756) Bipolar disorder with mood-incongruent psychosis ( 23092984) Blood protein levels ( 29875488) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) General cognitive ability ( 29844566) Hemoglobin levels ( 32327693) Insomnia symptoms (never/rarely vs. sometimes/usually) ( 30804566) Intelligence (MTAG) ( 29326435) Lymphocyte counts ( 32888494) Major mood disorders ( 20081856) Monocyte count ( 32888494) Red cell distribution width ( 32888494) Schizophrenia ( 28991256 25056061 29483656 30285260 23974872) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for body mass index ( 28448500) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for body mass index ( 25673412 28448500)	AIDS progression ( 21502085) Blood protein levels ( 28240269) Celiac disease ( 20190752) Cerebrospinal fluid levels of Alzheimer's disease-related proteins ( 25340798) Lymphocyte percentage of white cells ( 32888494) Macular thickness ( 30535121) Monocyte percentage of white cells ( 27863252) Pre-treatment viral load in HIV-1 infection ( 31219150) Setpoint viral load in HIV-1 infection ( 26553974) Ulcerative colitis ( 28067908)
Interacting Genes		11 interacting genes: APP H2AC20 H2BC21 H3C1 H4C1 PTEN PTS SMARCA4 SUMO2 ZDHHC17 ZNF512B	1 interacting genes: C4orf3
Entrez ID		55193	9034
HPRD ID		07302	16327
Ensembl ID		ENSG00000163939	ENSG00000121797
Uniprot IDs		Q86U86	B2R8C0 O00421
PDB IDs		2KTB 3G0J 3HMF 3IU5 3IU6 3K2J 3LJW 3MB4 3TLP 4Q0N 4Q0O 4Y03 5E7D 5FH6 5FH7 5FH8 5HRV 5HRW 5HRX 5II1 5II2 5IID 6OXB 6ZN6 6ZNV 6ZS3 6ZS4
Enriched GO Terms of Interacting Partners?
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