PBRM1 and H3C1

Data Source:
BioGRID (proximity labelling technology, proximity labelling technology, unspecified method)

		PBRM1	H3C1
Description		polybromo 1	H3 clustered histone 1
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GO Annotations	Cellular Component	Nuclear Chromosome Nucleoplasm RSC-type Complex	Nuclear Chromosome Nucleosome Extracellular Region Nucleus Nucleoplasm Membrane Protein-containing Complex Extracellular Exosome
	Molecular Function	DNA Binding Chromatin Binding Protein Binding	DNA Binding Protein Binding Cadherin Binding Protein Heterodimerization Activity
	Biological Process	Mitotic Cell Cycle Chromatin Remodeling Negative Regulation Of Cell Population Proliferation ATP-dependent Chromatin Remodeling	RDNA Heterochromatin Assembly Chromatin Organization Nucleosome Assembly DNA Replication-dependent Nucleosome Assembly Blood Coagulation Telomere Organization Interleukin-7-mediated Signaling Pathway Cellular Protein Metabolic Process Regulation Of Megakaryocyte Differentiation Negative Regulation Of Gene Expression, Epigenetic Regulation Of Gene Silencing By MiRNA Regulation Of Gene Silencing
Pathways		RMTs methylate histone arginines RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	Interleukin-7 signaling Interleukin-7 signaling Pre-NOTCH Transcription and Translation Formation of the beta-catenin:TCF transactivating complex PRC2 methylates histones and DNA Condensation of Prophase Chromosomes Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) HDACs deacetylate histones PKMTs methylate histone lysines HDMs demethylate histones HATs acetylate histones HATs acetylate histones RMTs methylate histone arginines Chromatin modifying enzymes SIRT1 negatively regulates rRNA expression ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression NoRC negatively regulates rRNA expression NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression DNA methylation Transcriptional regulation by small RNAs Activation of anterior HOX genes in hindbrain development during early embryogenesis Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 RNA Polymerase I Promoter Opening RNA Polymerase I Promoter Escape RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression Meiotic recombination HCMV Early Events HCMV Late Events Transcriptional regulation of granulopoiesis Amyloid fiber formation Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 21926972 31043756) Bipolar disorder with mood-incongruent psychosis ( 23092984) Blood protein levels ( 29875488) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) General cognitive ability ( 29844566) Hemoglobin levels ( 32327693) Insomnia symptoms (never/rarely vs. sometimes/usually) ( 30804566) Intelligence (MTAG) ( 29326435) Lymphocyte counts ( 32888494) Major mood disorders ( 20081856) Monocyte count ( 32888494) Red cell distribution width ( 32888494) Schizophrenia ( 28991256 25056061 29483656 30285260 23974872) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for body mass index ( 28448500) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for body mass index ( 25673412 28448500)
Interacting Genes		11 interacting genes: APP H2AC20 H2BC21 H3C1 H4C1 PTEN PTS SMARCA4 SUMO2 ZDHHC17 ZNF512B	156 interacting genes: AIRE AKT2 ANP32A ANP32B ASH1L ASH2L ATXN1 AURKA AURKB AURKC BCAS3 CARM1 CBX1 CBX3 CENPM CENPT CENPW CHD3 CHD4 COPS2 CREBBP CTCFL CUL4A DCAF1 DDB1 DNAJC9 DNMT1 DNMT3A DNMT3B DPF2 DYRK1A EED EHMT1 EHMT2 EID1 EP300 ERCC6 ESCO1 EZH2 FANCD2 FBLIM1 GATAD2A GATAD2B GLYR1 GRIP1 H2AC20 H4C14 HASPIN HAT1 HDAC1 HDAC2 HDAC3 HDAC5 HDAC6 HDAC8 HDGFL3 HNF1B HNRNPA1 HNRNPAB HPF1 HSPA8 ING4 JMJD6 KAT14 KAT2B KAT5 KAT6A KAT7 KDM1A KDM2B KDM4A KDM4C KDM6A KDM6B KMT2A KMT2B KMT2C L3MBTL2 MAD2L1 MBD5 MLLT3 MPHOSPH8 MSL3 MYB NAP1L1 NASP NCOR1 NR1H4 NR3C1 NSD1 NSD2 NSD3 PAF1 PAK1 PALB2 PARP1 PARP10 PARP2 PAXIP1 PBRM1 PHF1 PHF19 PHF20 PHF8 PIKFYVE PPM1D PPP1CA PPP1CB PRDM2 PRKCA PRKCB PRMT1 PRMT5 PRMT7 PWWP3B RAD51B RAG1 RBBP4 RBBP7 RCC1 RPS6KA3 SETD1A SETD1B SETD2 SETD7 SETDB1 SIRT1 SIRT2 SIRT3 SIRT7 SMARCA2 SMARCA4 SMARCA5 SUV39H1 TAF15 TAF1A TAF1B THAP7 TLE3 TRIM33 TSSK6 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E3 UHRF1 UHRF2 WDR5 WWC1 YEATS4 YWHAB YWHAG YWHAZ ZMYND8
Entrez ID		55193	8350
HPRD ID		07302	04155
Ensembl ID		ENSG00000163939	ENSG00000275714
Uniprot IDs		Q86U86	P68431
PDB IDs		2KTB 3G0J 3HMF 3IU5 3IU6 3K2J 3LJW 3MB4 3TLP 4Q0N 4Q0O 4Y03 5E7D 5FH6 5FH7 5FH8 5HRV 5HRW 5HRX 5II1 5II2 5IID 6OXB 6ZN6 6ZNV 6ZS3 6ZS4	1CS9 1CT6 1O9S 1Q3L 2B2T 2B2U 2B2V 2B2W 2C1J 2C1N 2CO0 2CV5 2FSA 2KWJ 2KWK 2L75 2LBM 2LGG 2M0O 2NDF 2NDG 2OQ6 2OT7 2OX0 2RI7 2RR4 2UXN 2V85 2V89 2VNF 2VPG 2X0L 3A1B 3AFA 3AVR 3AYW 3AZE 3AZF 3AZG 3AZH 3AZI 3AZJ 3AZK 3AZL 3AZM 3AZN 3B95 3FDT 3KMT 3KQI 3LQI 3LQJ 3MP1 3O34 3O35 3O37 3QJ6 3RIG 3RIY 3SOU 3SOW 3U31 3U3D 3U4S 3U5N 3U5O 3U5P 3UEE 3UEF 3UIG 3UII 3UIK 3V43 3W96 3W97 3W98 3W99 3WA9 3WAA 3WKJ 3X1S 3X1T 3X1U 3X1V 3ZG6 3ZVY 4A0J 4A0N 4A7J 4BD3 4C1Q 4F4U 4F56 4FWF 4HON 4I51 4L7X 4LK9 4LKA 4LLB 4LXL 4N4H 4QBQ 4QBR 4QBS 4TN7 4U68 4UP0 4UY4 4X3K 4Y6L 4YHP 4YHZ 4YM5 4YM6 4Z0R 4Z2M 5AV5 5AV6 5AV8 5AV9 5AVB 5AVC 5B24 5B2I 5B2J 5B31 5C11 5C13 5C3I 5CPI 5CPJ 5CPK 5D6Y 5DAH 5FB0 5FB1 5FFV 5GH9 5GSE 5GSU 5GT0 5GT3 5GTC 5H6Q 5H6R 5HJB 5HJC 5HJD 5HYN 5IQL 5J3V 5J9S 5JHN 5JIN 5JIY 5JJ0 5JRG 5KJH 5KJI 5KKL 5LUG 5M5G 5MR8 5NNC 5NND 5OY3 5SVX 5SVY 5SZB 5SZC 5T0K 5T0M 5T1G 5T1I 5T8R 5TBN 5TDR 5TDW 5U2J 5V21 5V22 5VA6 5VAB 5VGE 5VNB 5WFC 5WLE 5WVO 5WXG 5WXH 5WYI 5X60 5XF3 5XF4 5XF5 5XFQ 5XFR 5XNV 5XTZ 5Y0C 5Y0D 5Y20 5Y2F 5Z23 5Z30 6AXJ 6AZE 6BHD 6BHE 6BHG 6BHH 6BHI 6D07 6D08 6E83 6E86 6F6D 6HKT 6HTS 6IEU 6IIS 6IIT 6IPU 6IQ4 6JOU 6JR0 6JR1 6JXD 6K1I 6K1J 6K1K 6KE9 6KVD 6L49 6L4A 6L9H 6LA8 6LA9 6LE9 6M3V 6M44 6M4D 6M4G 6M4H 6MIL 6MIM 6MIN 6MIO 6MIQ 6R8Y 6R8Z 6R90 6R91 6R92 6R93 6R94 6T90 6T93 6UPK 6UPL 6USJ 6V2H 6V3N 6V41 6V92 6VIL 6WAV 6WW4 6YIF 6YIH 6YOV 7C0M 7CCQ 7CCR
Enriched GO Terms of Interacting Partners?
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