RIF1 and HAP1

Data Source:
HPRD (two hybrid)

		RIF1	HAP1
Description		replication timing regulatory factor 1	huntingtin associated protein 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromosome, Telomeric Region Chromatin Condensed Chromosome Female Pronucleus Male Pronucleus Nucleus Nucleoplasm Cytoplasm Plasma Membrane Nuclear Body Nuclear Membrane Site Of Double-strand Break Spindle Midzone	Nucleolus Mitochondrion Lysosome Early Endosome Autophagosome Endoplasmic Reticulum Centrosome Centriole Cytosol Cytoskeleton Synaptic Vesicle Actin Cytoskeleton Inclusion Body Dendrite Growth Cone Cytoplasmic Vesicle Dendritic Spine Axon Cytoplasm
	Molecular Function	Protein Binding	Signaling Receptor Binding Protein Binding Myosin Binding Ion Channel Binding Brain-derived Neurotrophic Factor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Telomere Maintenance Double-strand Break Repair Via Nonhomologous End Joining Chromatin Silencing At Telomere Cellular Response To DNA Damage Stimulus Cell Cycle Stem Cell Population Maintenance Telomere Maintenance In Response To DNA Damage Positive Regulation Of Isotype Switching Positive Regulation Of Histone H3-K9 Methylation Cellular Response To Leukemia Inhibitory Factor Negative Regulation Of Double-strand Break Repair Via Homologous Recombination Positive Regulation Of Double-strand Break Repair Via Nonhomologous End Joining	Protein Targeting Exocytosis Autophagy Chemical Synaptic Transmission Brain Development Anterograde Axonal Transport Retrograde Axonal Transport Protein Localization Regulation Of Exocytosis Cerebellum Development Hypothalamus Cell Differentiation Neurogenesis Cell Projection Organization Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Positive Regulation Of Synaptic Transmission, GABAergic Positive Regulation Of Neurotrophin Production Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Vesicle Transport Along Microtubule Neurotrophin TRK Receptor Signaling Pathway Mitochondrion Distribution Positive Regulation Of Neurogenesis Anterograde Axonal Transport Of Mitochondrion Negative Regulation Of Amyloid-beta Formation Regulation Of Organelle Transport Along Microtubule Positive Regulation Of Non-motile Cilium Assembly
Pathways		Nonhomologous End-Joining (NHEJ)
Drugs
Diseases
GWAS		Lung cancer ( 23143601) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483)	Developmental language disorder (syntactic complexity) ( 27016271) Esophageal cancer (squamous cell) ( 22960999)
Interacting Genes		20 interacting genes: BRD7 CEP126 CHD3 DEFB1 FEZ1 GIT1 GNE GRB2 HAP1 LINC00839 NSG2 PABPC4 PIAS4 POT1 PPP1CA PPP1CC SETDB1 SMARCD1 SUMO2 TERF2IP	93 interacting genes: AEN ANTKMT APLP1 ATP5MF BARD1 BRD7 C1orf216 C2CD6 C7orf25 C8orf33 CBX8 CCDC113 CCDC13 CDC73 CDK18 CDK5RAP2 COL9A2 CRIP1 DCTN1 DDX49 DEFB1 EIF3E FAM50B FEZ1 GABARAPL2 GADD45G GIT1 GPRASP2 HDAC4 HGS HMOX2 HOXB5 HSPA1A HSPA4 HTT IMMT ING5 KAT5 KAT7 KATNBL1 KBTBD7 KPNA2 LRIF1 LUC7L2 MPP3 MRPS9 MSGN1 NAP1L5 NDUFB9 NEUROD1 NIPSNAP3A NOD2 NOP53 PABPC4 PCM1 PDCD7 PFDN1 PKN1 PPID PPOX PPP1R18 PRPF31 PSMD11 RER1 RHPN1 RIF1 RPS10 RPS25 SCNM1 SNAPIN SRSF4 STX5 TAF1D TBP TIMM17A TNNT1 TNNT3 TOMM20 TSPYL1 UTP3 VIM ZFP1 ZMAT2 ZNF124 ZNF20 ZNF24 ZNF33B ZNF490 ZNF572 ZNF575 ZNF648 ZNF691 ZNF835
Entrez ID		55183	9001
HPRD ID		10603	02972
Ensembl ID		ENSG00000080345	ENSG00000173805
Uniprot IDs		Q5UIP0	P54257
PDB IDs
Enriched GO Terms of Interacting Partners?
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